Disease relevance of Scleroderma, Diffuse

• L-tryptophan ingestion associated with eosinophilic fasciitis but not progressive systemic sclerosis [1].
• However, the significant differences between diffuse scleroderma patients and CREST syndrome patients, for both intimal thickening and percentage of luminal occlusion, suggest that the arterial disease in these 2 patient subsets is distinctive [2].
• When compared with normal controls, antibody levels to the glycine-alanine peptides were significantly higher in patients with rheumatoid arthritis and progressive systemic sclerosis, but not in patients with two other autoimmune diseases [3].
• Identification and characterization of mitochondria autoantigens in progressive systemic sclerosis: identity with the 72,000 dalton autoantigen in primary biliary cirrhosis [4].
• Penicillamine-induced myasthenia gravis in progressive systemic sclerosis [5].

High impact information on Scleroderma, Diffuse

• These observations reveal short-term improvement in thallium-201 myocardial perfusion with nifedipine in patients with progressive systemic sclerosis [6].
• Nifedipine and thallium-201 myocardial perfusion in progressive systemic sclerosis [6].
• This report presents results of a study of Scl-70, an autoantigen recognized by sera of many patients with the most severe form of progressive systemic sclerosis [7].
• University of California, Davis (UCD) line 200 White Leghorn Chickens spontaneously develop a syndrome that has many analogous features to human progressive systemic sclerosis [8].
• Previous studies in Caucasians with progressive systemic sclerosis (PSS) have suggested associations of antitopoisomerase I (antitopo I) autoantibodies with either serologically defined HLA-DR2 or DR5 [9].

Chemical compound and disease context of Scleroderma, Diffuse

• Effects of cisapride on gastric and esophageal emptying in progressive systemic sclerosis [10].
• Minocycline in early diffuse scleroderma [11].
• D-Penicillamine therapy in progressive systemic sclerosis (scleroderma): a retrospective analysis [12].
• Penicillamine and progressive systemic sclerosis [13].
• Nifedipine treatment for progressive systemic sclerosis [14].

Biological context of Scleroderma, Diffuse

• The effects of cisapride on gastric emptying, esophageal emptying, and gastrointestinal symptoms were evaluated in 8 patients with progressive systemic sclerosis who had delayed gastric emptying of the solid or liquid component of a meal, or both [10].
• METHODS: Patients attending clinical immunology clinics who had progressive systemic sclerosis and related syndromes and who had received cyclosporin and/or tacrolimus were identified [15].
• Centromere protein CENP-A is a histone H3-like protein associated specifically with the centromere and represents one of the human autoantigens identified by sera taken from patients with the CREST variant of progressive systemic sclerosis [16].
• We hypothesize that CF formation in psoriasis is similar to that in other diseases accompanied by oxidative stress, in particular chronic inflammatory diseases with autoimmune reactions such as lupus erythematosus, progressive systemic sclerosis, rheumatoid arthritis and others [17].
• This study examined DcR3 gene expression in PBMC derived from patients with silicosis, SLE, or progressive systemic sclerosis (PSS), and compared it with that in healthy volunteers (HV) [18].

Anatomical context of Scleroderma, Diffuse

• Cyclic nucleotides and calcium transport in cultured dermal fibroblasts from progressive systemic sclerosis and rheumatoid arthritis patients [19].
• Effects of diltiazem versus nifedipine on lower esophageal sphincter pressure in patients with progressive systemic sclerosis [20].
• An autoantibody reactive with a 72,000 dalton centromeric antigen was detected by immunoblotting with the use of a nuclear enriched HeLa cell preparation in 42 of 77 patients with progressive systemic sclerosis (PSS) [21].
• Enterocyte function in progressive systemic sclerosis as estimated by the deconjugation of pteroyltriglutamate to folic acid [22].
• Markers of collagen and basement membrane metabolism in sera of patients with progressive systemic sclerosis [23].

Gene context of Scleroderma, Diffuse

• Patients with progressive systemic sclerosis (PSS; scleroderma) were typed for the HLA-A, -B, and -DR antigens [24].
• We measured the plasma concentrations of soluble type A (p75) and type B (p55) TNF receptors in patients with systemic lupus erythematodes (SLE), progressive systemic sclerosis (PSS), and mixed connective tissue disease (MCTD) [25].
• An Fc gamma RIII (CD16)-specific autoantibody from a patient with progressive systemic sclerosis [26].
• Serum amyloid A protein concentration in progressive systemic sclerosis (scleroderma) [27].
• Four met the American Rheumatism Association criteria for systemic lupus erythematosus, six for progressive scleroderma, and 14 for rheumatoid arthritis [28].

Analytical, diagnostic and therapeutic context of Scleroderma, Diffuse

• To investigate cardiopulmonary function in progressive systemic sclerosis with diffuse scleroderma, we studied 26 patients with maximal exercise and redistribution thallium scans, rest and exercise radionuclide ventriculography, pulmonary-function testing, and chest roentgenography [29].
• In a retrospective study on progressive systemic sclerosis, we compared 73 patients who had received D-penicillamine therapy for a minimum of 6 consecutive months with 45 patients who had not received this drug [12].
• To map Topo I epitopes, recombinant fusion proteins were analyzed by immunoblotting with 66 anti-Topo I sera from Thai and Australian patients with diffuse scleroderma [30].
• An intravenous infusion of 2,000 ml isotonic saline was performed in 8 normotensive, normoreninemic patients with progressive systemic sclerosis [31].
• The authors therefore tested the effect of intravenous injections of metoclopramide on the sphincteric pressure and esophageal motility in 14 patients with esophageal dysfunction due to progressive systemic sclerosis (PSS) [32].

References