Disease relevance of Retinal Neoplasms

• Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors [1].
• Retinoblastoma (RB), cancer of the retina, occurs in an inherited form which not only predisposes the patient to bilateral RB, but also to the risk of developing secondary tumors of mesenchymal origin (osteosarcomas and fibrosarcomas) [2].
• OBJECTIVE: The authors describe an ocular lesion combining the characteristics of persistent hyperplastic primary vitreous (PHPV) and a retinal tumor in an infant with tuberous sclerosis complex (TSC) [3].
• Chemotherapeutic response of tumor derived from human adenovirus 12--induced retinal tumor cell line in syngeneic CDF (F 344) rats [4].
• Using a commercially available antibody to GFA protein, a retinal neoplasm from a patient with neurofibromatosis is intensely stained with the brown immunoperoxidase reaction product [5].

High impact information on Retinal Neoplasms

• These results support the hypothesis that the regulation of N-myc in these neuronal and retinal tumor cells is similar to that of c-myc in other tumor types [6].
• PURPOSE: To evaluate the tumor control efficacy of the antiangiogenic agent anecortave acetate as single and combined therapy, in retinal tumor reduction using the LH(BETA)T(AG) mouse model of retinoblastoma [7].
• Anecortave acetate as single and adjuvant therapy in the treatment of retinal tumors of LH(BETA)T(AG) mice [7].
• METHODS: The 661W cells were cloned from retinal tumors of a transgenic mouse line that expresses the simian virus (SV) 40 T antigen under control of the human interphotoreceptor retinol-binding protein (IRBP) promoter [8].
• VDR transcripts were confirmed at the protein level by strong immunostaining of solid retinal tumors for VDR [9].

Chemical compound and disease context of Retinal Neoplasms

• The effect of two anticancer agents, vincristine (VCR) and cyclophosphamide (CTX), on an established cell line (EXP-5) derived from human adenovirus serotype 12 (Ad 12)--induced retinal tumor was studied in vitro and in vivo [4].

Gene context of Retinal Neoplasms

• Mutations within the retinoblastoma gene (RB1) are responsible for retinal tumors [10].
• Computed tomography of the brain revealed a midline suprasellar tumor without evidence of retinal tumors [11].

References