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MeSH Review

Retinal Neoplasms

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Disease relevance of Retinal Neoplasms


High impact information on Retinal Neoplasms

  • These results support the hypothesis that the regulation of N-myc in these neuronal and retinal tumor cells is similar to that of c-myc in other tumor types [6].
  • PURPOSE: To evaluate the tumor control efficacy of the antiangiogenic agent anecortave acetate as single and combined therapy, in retinal tumor reduction using the LH(BETA)T(AG) mouse model of retinoblastoma [7].
  • Anecortave acetate as single and adjuvant therapy in the treatment of retinal tumors of LH(BETA)T(AG) mice [7].
  • METHODS: The 661W cells were cloned from retinal tumors of a transgenic mouse line that expresses the simian virus (SV) 40 T antigen under control of the human interphotoreceptor retinol-binding protein (IRBP) promoter [8].
  • VDR transcripts were confirmed at the protein level by strong immunostaining of solid retinal tumors for VDR [9].

Chemical compound and disease context of Retinal Neoplasms


Gene context of Retinal Neoplasms


  1. Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors. Kratzke, R.A., Otterson, G.A., Hogg, A., Coxon, A.B., Geradts, J., Cowell, J.K., Kaye, F.J. Oncogene (1994) [Pubmed]
  2. 60Co radiation-induced transformation to anchorage independence of fibroblast from normal persons and patients with inherited predisposition to retinoblastoma. Wang, Y., Kateley-Kohler, S., Maher, V.M., McCormick, J.J. Carcinogenesis (1986) [Pubmed]
  3. Persistent hyperplastic primary vitreous with retinal tumor in tuberous sclerosis: report of a case including tumoral immunohistochemistry and cytogenetic analyses. Milot, J., Michaud, J., Lemieux, N., Allaire, G., Gagnon, M.M. Ophthalmology (1999) [Pubmed]
  4. Chemotherapeutic response of tumor derived from human adenovirus 12--induced retinal tumor cell line in syngeneic CDF (F 344) rats. Kobayashi, M., Mukai, N., Solish, S.P., Sawada, T., Pomeroy, M.E. Anticancer Res. (1983) [Pubmed]
  5. Localization of glial fibrillary acidic protein in retinal astrocytoma: an immunohistochemical study. Jiang, Q., Fratkin, J.D., Blodi, F.C. Curr. Eye Res. (1982) [Pubmed]
  6. Regulation of N-myc transcript stability in human neuroblastoma and retinoblastoma cells. Amy, C.M., Bartholomew, J.C. Cancer Res. (1987) [Pubmed]
  7. Anecortave acetate as single and adjuvant therapy in the treatment of retinal tumors of LH(BETA)T(AG) mice. Jockovich, M.E., Murray, T.G., Escalona-Benz, E., Hernandez, E., Feuer, W. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  8. Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice. Tan, E., Ding, X.Q., Saadi, A., Agarwal, N., Naash, M.I., Al-Ubaidi, M.R. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  9. 1,25-dihydroxyvitamin D3-induced apoptosis of retinoblastoma cells is associated with reciprocal changes of Bcl-2 and bax. Wagner, N., Wagner, K.D., Schley, G., Badiali, L., Theres, H., Scholz, H. Exp. Eye Res. (2003) [Pubmed]
  10. Genetic aspects of embryonic eye development in vertebrates. Graw, J. Dev. Genet. (1996) [Pubmed]
  11. Retinoblastoma as a congenital primary intracranial tumor. Al Omari, A., Mustafa, M.M., Hessler, R., Rejjal, A., Kattan, A. J. Pediatr. Hematol. Oncol. (1999) [Pubmed]
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