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MeSH Review

Ocular Physiology

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High impact information on Ocular Physiology

  • In flies lacking endogenous eye-PKC (inaCp215), normal visual physiology is restored upon expression of wild-type eye-PKC, whereas the eye-PKCI700D mutant is completely inactive [1].
  • Elucidating the roles of TSP1 and TSP2 in ocular physiology and pathobiology may lead to improved therapies for neovascular, neoplastic, reparative and other ophthalmic diseases [2].
  • Eventual identification of molecules that bear the HNK-1 epitope in the eye will likely shed light on many aspects of ocular physiology and pathobiology[3]
  • The cacH18 mutant exhibits defects in visual physiology (including complete unresponsiveness to light in certain genetic combinations) and visually mediated behaviors; this mutant (originally nbAH18) has a stop codon in an alternative exon (within the cac ORF), which is differentially expressed in the eye [4].
  • The cacS mutant, which exhibits defects in the patterning of courtship lovesong and a newly revealed but subtle abnormality in visual physiology, is mutated such that a highly conserved phenylalanine (in one of the quasi-homologous intrapolypeptide regions called IIIS6) is replaced by isoleucine [4].

Associations of Ocular Physiology with chemical compounds


Gene context of Ocular Physiology


  1. Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies. Adamski, F.M., Zhu, M.Y., Bahiraei, F., Shieh, B.H. J. Biol. Chem. (1998) [Pubmed]
  2. Thrombospondin 1, thrombospondin 2 and the eye. Hiscott, P., Paraoan, L., Choudhary, A., Ordonez, J.L., Al-Khaier, A., Armstrong, D.J. Progress in retinal and eye research. (2006) [Pubmed]
  3. The HNK-1 carbohydrate epitope in the eye: basic science and functional implications. Uusitalo, M., Kivelä, T. Progress in retinal and eye research. (2001) [Pubmed]
  4. Courtship and visual defects of cacophony mutants reveal functional complexity of a calcium-channel alpha1 subunit in Drosophila. Smith, L.A., Peixoto, A.A., Kramer, E.M., Villella, A., Hall, J.C. Genetics (1998) [Pubmed]
  5. Angiotensin-converting enzyme activity in ocular fluids. Vita, J.B., Anderson, J.A., Hulem, C.D., Leopold, I.H. Invest. Ophthalmol. Vis. Sci. (1981) [Pubmed]
  6. Retinal melatonin is not involved in corneal mitotic rhythms in the Japanese quail: effects of formoguanamine hydrochloride and eye-lid suture. Oishi, T., Mohri, Y., Kaneko, T., Sasaki, M., Hattori, A., Obara, Y., Masuda, A. J. Pineal Res. (1996) [Pubmed]
  7. Changes in ocular physiology, tear film characteristics, and symptomatology with 18 months silicone hydrogel contact lens wear. Santodomingo-Rubido, J., Wolffsohn, J.S., Gilmartin, B. Optometry and vision science : official publication of the American Academy of Optometry. (2006) [Pubmed]
  8. Blood pressure responses as an indicator of the anesthetic level in ground squirrels. Gur, M., Purple, R.L. Journal of applied physiology. (1976) [Pubmed]
  9. Characterization of alpha 2-macroglobulin binding to human trabecular meshwork cells: presence of the alpha 2-macroglobulin signaling receptor. Howard, G.C., Roberts, B.C., Epstein, D.L., Pizzo, S.V. Arch. Biochem. Biophys. (1996) [Pubmed]
  10. Vasoactive intestinal polypeptide-like immunoreactive nerves to the human eye. Stone, R.A., Tervo, T., Tervo, K., Tarkkanen, A. Acta ophthalmologica. (1986) [Pubmed]
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