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Gene Review

THBS2  -  thrombospondin 2

Homo sapiens

Synonyms: TSP2, Thrombospondin-2
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Disease relevance of THBS2


High impact information on THBS2

  • A recombinant piece of TSP2 containing this sequence replicated the alpha4beta1 integrin-dependent activities of TSP1 [5].
  • The alpha4beta1 integrin recognition site is conserved in TSP2 [5].
  • Recombinant pieces of TSP-1 and TSP-2 incorporating combinations of domains that span the entire subunit were produced in insect cells and examined for VWF reductase activity [6].
  • Thus, thrombospondin 2 mRNA may be present in the developing brain at low levels in endothelial cells or blood cells [7].
  • Thrombospondin 2 mRNA was detected in poly(A) RNA isolated from embryonic spinal cord and cerebellum by polymerase chain reaction, though it was not detected in poly(A) RNA from the avascular retina [7].

Biological context of THBS2


Anatomical context of THBS2


Associations of THBS2 with chemical compounds


Regulatory relationships of THBS2


Other interactions of THBS2


Analytical, diagnostic and therapeutic context of THBS2


  1. Frequent HOXA11 and THBS2 promoter methylation, and a methylator phenotype in endometrial adenocarcinoma. Whitcomb, B.P., Mutch, D.G., Herzog, T.J., Rader, J.S., Gibb, R.K., Goodfellow, P.J. Clin. Cancer Res. (2003) [Pubmed]
  2. Thrombospondin 1, thrombospondin 2 and the eye. Hiscott, P., Paraoan, L., Choudhary, A., Ordonez, J.L., Al-Khaier, A., Armstrong, D.J. Progress in retinal and eye research. (2006) [Pubmed]
  3. Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer. Tokunaga, T., Nakamura, M., Oshika, Y., Abe, Y., Ozeki, Y., Fukushima, Y., Hatanaka, H., Sadahiro, S., Kijima, H., Tsuchida, T., Yamazaki, H., Tamaoki, N., Ueyama, Y. Br. J. Cancer (1999) [Pubmed]
  4. Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction. Boekholdt, S.M., Trip, M.D., Peters, R.J., Engelen, M., Boer, J.M., Feskens, E.J., Zwinderman, A.H., Kastelein, J.J., Reitsma, P.H. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  5. Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. Li, Z., Calzada, M.J., Sipes, J.M., Cashel, J.A., Krutzsch, H.C., Annis, D.S., Mosher, D.F., Roberts, D.D. J. Cell Biol. (2002) [Pubmed]
  6. The von Willebrand factor-reducing activity of thrombospondin-1 is located in the calcium-binding/C-terminal sequence and requires a free thiol at position 974. Pimanda, J.E., Annis, D.S., Raftery, M., Mosher, D.F., Chesterman, C.N., Hogg, P.J. Blood (2002) [Pubmed]
  7. The in situ localization of tenascin splice variants and thrombospondin 2 mRNA in the avian embryo. Tucker, R.P. Development (1993) [Pubmed]
  8. Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans. LaBell, T.L., Milewicz, D.J., Disteche, C.M., Byers, P.H. Genomics (1992) [Pubmed]
  9. Analysis of the promoter and transcription start sites of the human thrombospondin 2 gene (THBS2). Adolph, K.W., Liska, D.J., Bornstein, P. Gene (1997) [Pubmed]
  10. Thrombospondin-1 and -2 messenger RNA expression in normal and neoplastic endometrial tissues: correlation with angiogenesis and prognosis. Seki, N., Kodama, J., Hashimoto, I., Hongo, A., Yoshinouchi, M., Kudo, T. Int. J. Oncol. (2001) [Pubmed]
  11. Overexpression of the thrombospondin 2 (TSP2) gene modulated by the matrix metalloproteinase family expression and production in human colon carcinoma cell line. Kamochi, J., Tokunaga, T., Tomii, Y., Abe, Y., Hatanaka, H., Kijima, H., Yamazaki, H., Watanabe, N., Matsuzaki, S., Ueyama, Y., Nakamura, M. Oncol. Rep. (2003) [Pubmed]
  12. Thrombospondin-1 and -2 messenger RNA expression in invasive cervical cancer: correlation with angiogenesis and prognosis. Kodama, J., Hashimoto, I., Seki, N., Hongo, A., Yoshinouchi, M., Okuda, H., Kudo, T. Clin. Cancer Res. (2001) [Pubmed]
  13. Structure of the calcium-rich signature domain of human thrombospondin-2. Carlson, C.B., Bernstein, D.A., Annis, D.S., Misenheimer, T.M., Hannah, B.L., Mosher, D.F., Keck, J.L. Nat. Struct. Mol. Biol. (2005) [Pubmed]
  14. Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2. Misenheimer, T.M., Mosher, D.F. J. Biol. Chem. (2005) [Pubmed]
  15. An N-terminal 80 kDa recombinant fragment of human thrombospondin-2 inhibits vascular endothelial growth factor induced endothelial cell migration in vitro and tumor growth and angiogenesis in vivo. Noh, Y.H., Matsuda, K., Hong, Y.K., Kunstfeld, R., Riccardi, L., Koch, M., Oura, H., Dadras, S.S., Streit, M., Detmar, M. J. Invest. Dermatol. (2003) [Pubmed]
  16. A model for co-expression pattern analysis of genes implicated in angiogenesis and tumour cell invasion in cervical cancer. Van Trappen, P.O., Ryan, A., Carroll, M., Lecoeur, C., Goff, L., Gyselman, V.G., Young, B.D., Lowe, D.G., Pepper, M.S., Shepherd, J.H., Jacobs, I.J. Br. J. Cancer (2002) [Pubmed]
  17. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. McCarthy, J.J., Parker, A., Salem, R., Moliterno, D.J., Wang, Q., Plow, E.F., Rao, S., Shen, G., Rogers, W.J., Newby, L.K., Cannata, R., Glatt, K., Topol, E.J. J. Med. Genet. (2004) [Pubmed]
  18. Suppression of thrombospondin 1 and 2 production by herpes simplex virus 1 infection in cultured keratocytes. Choudhary, A., Hiscott, P., Hart, C.A., Kaye, S.B., Batterbury, M., Grierson, I. Mol. Vis. (2005) [Pubmed]
  19. Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis. Tran, M.H., Pearson, M.S., Bethony, J.M., Smyth, D.J., Jones, M.K., Duke, M., Don, T.A., McManus, D.P., Correa-Oliveira, R., Loukas, A. Nat. Med. (2006) [Pubmed]
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