High impact information on Xenodiagnosis

• In this study, the reservoir role of Apodemus mice for B. garinii OspA serotype 4 was demonstrated by xenodiagnosis [1].
• Positive xenodiagnosis was associated with lower lymphoblastogenic responses to T. cruzi in group 1 patients, suggesting the presence of a regulatory or modulatory mechanism which is lost in patients with chagasic cardiomyopathy [2].
• The presence of Trypanosoma cruzi in chronic chagasic patients with negative xenodiagnosis (XD) after 6 years following completion of therapy with either itraconazole or allopurinol was assessed by polymerase chain reaction (PCR) and hybridization assays [3].
• Parasitologic (xenodiagnosis, hemoculture, or both), histopathologic (hematoxylin and eosin, and peroxidase-anti-peroxidase staining), and molecular (polymerase chain reaction [PCR] followed by slot-blot hybridization) tests were used in the analysis [4].
• The highest percentage of lytic sera was observed when MF or V115 strains were used as target cells (90% and 71%, respectively) in the chronic chagasic group with negative xenodiagnosis results [5].

Associations of Xenodiagnosis with chemical compounds

• The latex Chagas test shows a mean coincidence of 90% with xenodiagnosis, 88% with CF, 75% with IFT, and 83% with IHA [6].

Gene context of Xenodiagnosis

• As TUE with negative PPFP presented negative xenodiagnosis and positive or oscillating CSA, they were classified as dissociated according to the criteria of Krettli and Brener (J. Immunol. 128:2009-2012, 1982) and could indeed be considered cured after chemotherapy [7].

References