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Disease relevance of Murinae


Psychiatry related information on Murinae

  • Feeding and drinking behavior were studied in deprived or sated spiny mice (Acomys cahirinus) at various time intervals following peripheral administration of naloxone hydrochloride and butorphanol tartrate [6].
  • Orientation and movement patterns of the wood mouse (Apodemus sylvaticus) in its home range are not altered by olfactory or visual deprivation [7].
  • Male spiny mice (Acomys cahirinus) were challenged with several putative dipsogenic stimulus conditions: hypertonic sodium chloride (NaCl), 24-h water deprivation, d,l-isoproterenol HCl, angiotensin II (AII) and polyethylene glycol (PEG), or control conditions, in within-subjects designs [8].

High impact information on Murinae

  • We investigated the rate and pattern of evolution for the coding sequence of Sry in Old World mice and rats (subfamily Murinae) [9].
  • Sixteen samples of Formalin-fixed, paraffin-embedded primary gastric carcinoids of Mastomys were stained by the same immunohistochemical method for 5-HT detection [1].
  • Mastomys bearing a large growing transplant and excreting a large amount of 5-hydroxy-indoleacetic acid [(5-HIAA) CAS: 54-16-0] were associated often with reddening of the nose, lower lip, auricles, hands, and feet [10].
  • Mastomys bearing growing transplants excreted 11.3 times more histamine and 4.4 times more 5-hydroxyindole-3-acetic acid (5-HIAA) in the urine than did Mastomys in which transplanted tumors did not grow [11].
  • Response of two rodents, Mastomys natalensis and Mystromys albicaudatus, to the pancreatic carcinogen azaserine [12].

Chemical compound and disease context of Murinae


Biological context of Murinae


Anatomical context of Murinae


Associations of Murinae with chemical compounds

  • The same ether-provoked flushing as found in tumor-bearing Mastomys could be reproduced in normal ones by constant infusion of 20 mg 5-HT/kg/24 hours (i.e., doses comparable to those released from a transplanted tumor) through an osmotic minipump implanted subcutaneously [10].
  • Vascular liver tumors induced in Mastomys (Praomys) natalensis by single or twofold administration of dimethylnitrosamine [26].
  • The mean early (two-minute) plasma insulin response was significantly lower in Acomys at all doses of glucose injected; whereas, at later times (5, 15, and 30 minutes), differences in plasma insulin concentrations in the two species of mice were smaller or nonexistent [18].
  • The results demonstrate that histamine 2-receptor blockade initiated by loxtidine promotes a rapid development of enterochromaffinlike cell tumors in Mastomys and suggest a critical role for gastrin in the formation of these tumors [27].
  • The metabolism of cyclic AMP and glucose in isolated islets from Acomys cahirinus [22].

Gene context of Murinae


Analytical, diagnostic and therapeutic context of Murinae


  1. Production of serotonin by a transplantable strain of histamine-producing primary gastric carcinoid of Mastomys natalensis. Suyama, M., Saito, T., Hara, K., Kito, H., Hosoda, S. J. Natl. Cancer Inst. (1984) [Pubmed]
  2. Praomys (Mastomys) natalensis: animal model for study of histamine-induced duodenal ulcers. Hosoda, S., Ikedo, H., Saito, T. Gastroenterology (1981) [Pubmed]
  3. Effect of diet-induced obesity on glucose and insulin tolerance of a rodent with a low insulin response (Acomys cahirinus). Gutzeit, A., Renold, A.E., Cerasi, E., Shafrir, E. Diabetes (1979) [Pubmed]
  4. Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis. Helfrich, I., Chen, M., Schmidt, R., Fürstenberger, G., Kopp-Schneider, A., Trick, D., Gröne, H.J., Zur Hausen, H., Rösl, F. J. Virol. (2004) [Pubmed]
  5. Isolation of the etiologic agent of Korean Hemorrhagic fever. Lee, H.W., Lee, P.W., Johnson, K.M. J. Infect. Dis. (1978) [Pubmed]
  6. Opioid modulation of ingestive behaviors in the spiny mouse (Acomys cahirinus). Czech, D.A. Life Sci. (1987) [Pubmed]
  7. Orientation and movement patterns of the wood mouse (Apodemus sylvaticus) in its home range are not altered by olfactory or visual deprivation. Benhamou, S. J. Comp. Physiol. A (2001) [Pubmed]
  8. Drinking behavior in the spiny mouse (Acomys cahirinus) following putative dipsogenic challenges. Czech, D.A., Vander Zanden, J.M. Pharmacol. Biochem. Behav. (1991) [Pubmed]
  9. Rapid evolution of the sex determining locus in Old World mice and rats. Tucker, P.K., Lundrigan, B.L. Nature (1993) [Pubmed]
  10. Novel flushing provoked by volatile anesthetics in Mastomys natalensis bearing a transplantable substrain of gastric carcinoid that predominantly secretes serotonin. Hosoda, S., Suyama, M., Saito, T., Kohmura, Y., Hosoda, R. J. Natl. Cancer Inst. (1984) [Pubmed]
  11. Transplantable argyrophilic gastric carcinoid of Mastomys natalensis secreting both histamine and serotonin. Hosoda, S., Suzuki, K., Sudo, K., Yoshida, N., Tanaka, C. J. Natl. Cancer Inst. (1979) [Pubmed]
  12. Response of two rodents, Mastomys natalensis and Mystromys albicaudatus, to the pancreatic carcinogen azaserine. Roebuck, B.D., Longnecker, D.S. J. Natl. Cancer Inst. (1979) [Pubmed]
  13. The effect of intracerebroventricular administration of catecholamines and their antagonists on rectal temperature of Mastomys natalensis. Shukla, R., Srimal, R.C., Dhawan, B.N. Naunyn Schmiedebergs Arch. Pharmacol. (1981) [Pubmed]
  14. Overnutrition in spiny mice (Acomys cahirinus): beta-cell expansion leading to rupture and overt diabetes on fat-rich diet and protective energy-wasting elevation in thyroid hormone on sucrose-rich diet. Shafrir, E. Diabetes Metab. Res. Rev. (2000) [Pubmed]
  15. Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis). Holmes, E., Bonner, F.W., Nicholson, J.K. Arch. Toxicol. (1995) [Pubmed]
  16. Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin. Ito, M., Matsui, T., Taniguchi, T., Tsukamoto, T., Murayama, T., Arima, N., Nakata, H., Chiba, T., Chihara, K. J. Biol. Chem. (1993) [Pubmed]
  17. Interspecies polymorphisms confer constitutive activity to the Mastomys cholecystokinin-B/gastrin receptor. Schaffer, K., McBride, E.W., Beinborn, M., Kopin, A.S. J. Biol. Chem. (1998) [Pubmed]
  18. Insulin secretion in the spiny mouse (Acomys cahirinus). Dose and time kinetic studies with glucose in vivo and in vitro. Rabinovitch, A., Gutzeit, A., Renold, A.E., Cerasi, E. Diabetes (1975) [Pubmed]
  19. Reduced early and late phase insulin response to glucose in isolated spiny mouse (Acomys cahirinus) islets: a defective link between glycolysis and adenylate cyclase. Nesher, R., Abramovitch, E., Cerasi, E. Diabetologia (1989) [Pubmed]
  20. Factors influencing replicon organization in tissues having different S-phase durations in the mole rat, Bandicota bengalensis. Dubey, D.D., Raman, R. Chromosoma (1987) [Pubmed]
  21. The role of transforming growth factor alpha in the enterochromaffin-like cell tumor autonomy in an African rodent mastomys. Tang, L.H., Modlin, I.M., Lawton, G.P., Kidd, M., Chinery, R. Gastroenterology (1996) [Pubmed]
  22. The metabolism of cyclic AMP and glucose in isolated islets from Acomys cahirinus. Grill, V., Cerasi, E. Diabetologia (1979) [Pubmed]
  23. Histidine decarboxylase expression and histamine metabolism in gastric oxyntic mucosa during hypergastrinemia and carcinoid tumor formation. Kölby, L., Wängberg, B., Ahlman, H., Modlin, I.M., Granérus, G., Theodorsson, E., Nilsson, O. Endocrinology (1996) [Pubmed]
  24. Identification of somatostatin and gastrin receptors on enterochromaffin-like cells from Mastomys gastric tumors. Reubi, J.C., Waser, B., Horisberger, U., Halter, F., Soroka, C.J., Kumar, R.R., Goldenring, J.R., Modlin, I.M. Endocrinology (1992) [Pubmed]
  25. Effect of electrical stimulation of the vagus nerve on insulinemia and glycemia in Acomys cahirinus mice. Ionescu, E., Jeanrenaud, B. Endocrinology (1988) [Pubmed]
  26. Vascular liver tumors induced in Mastomys (Praomys) natalensis by single or twofold administration of dimethylnitrosamine. Wayss, K., Bannasch, P., Mattern, J., Volm, M. J. Natl. Cancer Inst. (1979) [Pubmed]
  27. Rapid induction of enterochromaffinlike cell tumors by histamine2-receptor blockade. Nilsson, O., Wängberg, B., Johansson, L., Theodorsson, E., Dahlström, A., Modlin, I.M., Ahlman, H. Am. J. Pathol. (1993) [Pubmed]
  28. Positive selection for indel substitutions in the rodent sperm protein catsper1. Podlaha, O., Webb, D.M., Tucker, P.K., Zhang, J. Mol. Biol. Evol. (2005) [Pubmed]
  29. Significance of gastric endocrine tumor and age-related gut peptide alterations in Mastomys. Bilchik, A.J., Nilsson, O., Modlin, I.M., Zucker, K.A., Adrian, T.E. Regul. Pept. (1990) [Pubmed]
  30. Somatostatin receptor regulation of gastric enterochromaffin-like cell transformation to gastric carcinoid. Borin, J.F., Tang, L.H., Kidd, M., Miu, K., Borteçen, K.H., Sandor, A., Modlin, I.M. Surgery (1996) [Pubmed]
  31. Somatostatin receptor regulation of gastric carcinoid tumours. Tang, L.H., Modlin, I.M. Digestion (1996) [Pubmed]
  32. Fertilization of oocytes and birth of normal pups following intracytoplasmic injection with spermatids in mastomys (Praomys coucha). Ogonuki, N., Mochida, K., Inoue, K., Matsuda, J., Yamamoto, Y., Takano, K., Ogura, A. Biol. Reprod. (2003) [Pubmed]
  33. Characterization of kallikrein cDNAs from the African rodent Mastomys. Fahnestock, M. DNA Cell Biol. (1994) [Pubmed]
  34. Sexual dimorphism of GABAA receptor levels in subcortical brain regions of a woodland rodent (Apodemus sylvaticus). Canonaco, M., Tavolaro, R., Facciolo, R.M., Carelli, A., Cagnin, M., Cristaldi, M. Brain Res. Bull. (1996) [Pubmed]
  35. Effect of praziquantel on clinical-chemical parameters in healthy and schistosome-infected mice. Andrews, P., Dycka, J., Frank, G. Ann. Trop. Med. Parasitol. (1980) [Pubmed]
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