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Chemical Compound Review

Eosine     disodium2-(2,4,5,7- tetrabromo-6-oxido-3...

Synonyms: Eosine A, Eosine B, Eosine G, Eosine J, Eosine Y, ...
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Disease relevance of Eosine

  • Specificity of cellular fluorescence for nevus and melanoma cells was shown on serial sections stained with hematoxylin and eosin and was inferred for melanocytes from their distribution in human skin and their presence when the normal but not vitiliginous skin of both patients was used as substrate [1].
  • Forty-six cultured cell lines of diverse human tumor origins, including 25 melanoma cell lines, were HLA allotyped with the use of a modified eosin complement-dependent cytotoxicity test in combination with absorption and two-color fluorescence techniques [2].
  • FINDINGS: Occult nodal metastases were detected by serial sectioning and haematoxylin and eosin in 52 (7%) of 736 patients and by immunohistochemistry in 148 (20%) [3].
  • A study of benzidine-stained sections and hematoxylin and eosin-stained sections revealed marked engorgement of microvessels and hemorrhage in the superficial mucosa after ethanol injury [4].
  • A further 2 patients continued to complain of dyspepsis, and repeat endoscopy showed duodenitis, confirmed by conventional light microscopy (haematoxylin and eosin) [5].

High impact information on Eosine

  • In hematoxylin and eosin-stained paraffin sections, we detect empty lacunae in osteocytes in calvariae from Col1a1(r/r) mice at age 2 weeks, increasing through age 10-12 months [6].
  • Apoptosis-positive cells were counted in anatomic areas with different severity of ischemic injury characterized by magnetic resonance imaging, triphenyltetrazolium chloride, and hemotoxylin and eosin staining [7].
  • The nuclei of the small compact hepatocytes found in the animals with PCS were irregular in shape and stained intensively with hematoxylin and eosin [8].
  • The lesions were recognized in sections stained with hematoxylin and eosin because acinar cells forming islet-sized foci or larger nodules contained one or more of the following cytologic abnormalities: reduced cytoplasmic basophilia, reduced cytoplasm, reduced zymogen, cytoplasmic vacuoles, or nuclear abnormalities [9].
  • At endoscopy, four biopsy samples were taken for histology (haematoxylin and eosin) and H. pylori detection (giemsa in both antrum and corpus, culture and rapid urease test) [10].

Chemical compound and disease context of Eosine


Biological context of Eosine


Anatomical context of Eosine


Associations of Eosine with other chemical compounds


Gene context of Eosine

  • Exploiting differences in the peptides' aggregational properties, we present evidence that the two dyes Eosin and Direct Red 254, in conjunction with classical amyloid staining by Congo Red, can be used to characterize aggregating, amyloid-like peptides in vitro [30].
  • The mRNA for perforin was increased in sIBM (28.1 +/- 8.7) compared with controls (4.3 +/- 11.2, P = 0.18), and significantly correlated with mRNA of ICOS, ICOS-L and the degree of endomysial inflammation as assessed in coded haematoxylin/eosin tissue sections [31].
  • AdoMet lowered the pathology in CCl4-treated mice as shown by transaminase levels, hematoxylin and eosin, Masson's trichrome staining, and collagen I expression. beta-Galactosidase activity indicated activation of the COL1A2 promoter in stellate cells from CCl4-treated mice and repression of such activation by AdoMet [32].
  • To study the formation of PD-associated nigral inclusions, we analyzed the substantia nigra of cases with abundant LBs and PBs in hematoxylin and eosin (H&E) stain, using immunohistochemistry for alphaS, Ub, and p62 [33].
  • Haematoxylin and eosin staining, macrophage immunostaining, and electron microscopy showed that the Abeta fibril deposits closely correlated with degeneration of pancreatic acinar cells and macrophage activation [34].

Analytical, diagnostic and therapeutic context of Eosine


  1. Autoimmune vitiligo: detection of antibodies to melanin-producing cells. Hertz, K.C., Gazze, L.A., Kirkpatrick, C.H., Katz, S.I. N. Engl. J. Med. (1977) [Pubmed]
  2. HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines. Pollack, M.S., Heagney, S.D., Livingston, P.O., Fogh, J. J. Natl. Cancer Inst. (1981) [Pubmed]
  3. Role of immunohistochemical detection of lymph-node metastases in management of breast cancer. International Breast Cancer Study Group. Cote, R.J., Peterson, H.F., Chaiwun, B., Gelber, R.D., Goldhirsch, A., Castiglione-Gertsch, M., Gusterson, B., Neville, A.M. Lancet (1999) [Pubmed]
  4. Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat: effect of prostaglandin cytoprotection. Guth, P.H., Paulsen, G., Nagata, H. Gastroenterology (1984) [Pubmed]
  5. Is duodenitis a dyspeptic myth? Thomson, W.O., Joffe, S.N., Robertson, A.G., Lee, F.D., Imrie, C.W., Blumgart, L.H. Lancet (1977) [Pubmed]
  6. Osteocyte and osteoblast apoptosis and excessive bone deposition accompany failure of collagenase cleavage of collagen. Zhao, W., Byrne, M.H., Wang, Y., Krane, S.M. J. Clin. Invest. (2000) [Pubmed]
  7. Transient cerebral ischemia. Association of apoptosis induction with hypoperfusion. Vexler, Z.S., Roberts, T.P., Bollen, A.W., Derugin, N., Arieff, A.I. J. Clin. Invest. (1997) [Pubmed]
  8. Histochemical changes in livers from portacaval-shunted rats. Evarts, R.P., Raab, M., Marsden, E., Thorgeirsson, S.S. J. Natl. Cancer Inst. (1986) [Pubmed]
  9. Relationship of age to prevalence of focal acinar cell dysplasia in the human pancreas. Longnecker, D.S., Hashida, Y., Shinozuka, H. J. Natl. Cancer Inst. (1980) [Pubmed]
  10. Diagnosis of Helicobacter pylori infection with a new non-invasive antigen-based assay. HpSA European study group. Vaira, D., Malfertheiner, P., Mégraud, F., Axon, A.T., Deltenre, M., Hirschl, A.M., Gasbarrini, G., O'Morain, C., Garcia, J.M., Quina, M., Tytgat, G.N. Lancet (1999) [Pubmed]
  11. Chemical modification of matrix porin from Escherichia coli: probing the pore topology of a transmembrane protein. Schindler, M., Rosenbusch, J.P. J. Cell Biol. (1982) [Pubmed]
  12. Diencephalic and cerebellar pathology in alcoholic and nonalcoholic patients with end-stage liver disease. Kril, J.J., Butterworth, R.F. Hepatology (1997) [Pubmed]
  13. Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia. Minematsu, K., Li, L., Fisher, M., Sotak, C.H., Davis, M.A., Fiandaca, M.S. Neurology (1992) [Pubmed]
  14. Position of transfer ribonucleic acid on Escherichia coli ribosomes. Distance from the 3' end of 16S ribonucleic acid to three points on phenylalanine-accepting transfer ribonucleic acid in the donor site of 70S ribosomes. Robbins, D., Odom, O.W., Lynch, J., Kramer, G., Hardesty, B., Liou, R., Ofengand, J. Biochemistry (1981) [Pubmed]
  15. Suppression of graft-versus-host reactivity in the mouse popliteal node by UVB radiation. Morison, W.L., Pike, R.A. J. Invest. Dermatol. (1985) [Pubmed]
  16. H2O2-induced uncoupling of bovine lens Na+,K+-ATPase. Garner, W.H., Garner, M.H., Spector, A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  17. Phosphorylation by protein kinase C of serine-23 of the alpha-1 subunit of rat Na+,K(+)-ATPase affects its conformational equilibrium. Logvinenko, N.S., Dulubova, I., Fedosova, N., Larsson, S.H., Nairn, A.C., Esmann, M., Greengard, P., Aperia, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  18. Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7/rd7 mice. Haider, N.B., Naggert, J.K., Nishina, P.M. Hum. Mol. Genet. (2001) [Pubmed]
  19. Implication of Bcl-2 family genes in basal and D-amphetamine-induced apoptosis in preneoplastic and neoplastic rat liver lesions. De Miglio, M.R., Muroni, M.R., Simile, M.M., Calvisi, D.F., Tolu, P., Deiana, L., Carru, A., Bonelli, G., Feo, F., Pascale, R.M. Hepatology (2000) [Pubmed]
  20. Patterns of status epilepticus-induced neuronal injury during development and long-term consequences. Sankar, R., Shin, D.H., Liu, H., Mazarati, A., Pereira de Vasconcelos, A., Wasterlain, C.G. J. Neurosci. (1998) [Pubmed]
  21. Sequential hepatic histologic and histochemical changes produced by diethylnitrosamine in the rhesus monkey. Ruebner, B.H., Michas, C., Kanayama, R., Bannasch, P. J. Natl. Cancer Inst. (1976) [Pubmed]
  22. An inflammatory axonopathy of the myenteric plexus producing a rapidly progressive intestinal pseudoobstruction. Krishnamurthy, S., Schuffler, M.D., Belic, L., Schweid, A.I. Gastroenterology (1986) [Pubmed]
  23. Megacolon in myotonic dystrophy caused by a degenerative neuropathy of the myenteric plexus. Yoshida, M.M., Krishnamurthy, S., Wattchow, D.A., Furness, J.B., Schuffler, M.D. Gastroenterology (1988) [Pubmed]
  24. Severe idiopathic constipation is associated with a distinctive abnormality of the colonic myenteric plexus. Krishnamurthy, S., Schuffler, M.D., Rohrmann, C.A., Pope, C.E. Gastroenterology (1985) [Pubmed]
  25. Distribution and mobility of murine histocompatibility H-2Kk antigen in the cytoplasmic membrane. Damjanovich, S., Trón, L., Szöllösi, J., Zidovetzki, R., Vaz, W.L., Regateiro, F., Arndt-Jovin, D.J., Jovin, T.M. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  26. Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury. Soares, H.D., Hicks, R.R., Smith, D., McIntosh, T.K. J. Neurosci. (1995) [Pubmed]
  27. The differing effects of occipital and trunk somites on neural development in the chick embryo. Lim, T.M., Lunn, E.R., Keynes, R.J., Stern, C.D. Development (1987) [Pubmed]
  28. Comparison of epidermal growth factor (EGF) receptor-receptor interactions in intact A431 cells and isolated plasma membranes. Large scale receptor micro-aggregation is not detected during EGF-stimulated early events. Carraway, K.L., Cerione, R.A. J. Biol. Chem. (1991) [Pubmed]
  29. Platelet-derived growth factor causes pulmonary cell proliferation and collagen deposition in vivo. Yi, E.S., Lee, H., Yin, S., Piguet, P., Sarosi, I., Kaufmann, S., Tarpley, J., Wang, N.S., Ulich, T.R. Am. J. Pathol. (1996) [Pubmed]
  30. Amyloid-like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11. Hilbich, C., Mönning, U., Grund, C., Masters, C.L., Beyreuther, K. J. Biol. Chem. (1993) [Pubmed]
  31. Upregulated inducible co-stimulator (ICOS) and ICOS-ligand in inclusion body myositis muscle: significance for CD8+ T cell cytotoxicity. Schmidt, J., Rakocevic, G., Raju, R., Dalakas, M.C. Brain (2004) [Pubmed]
  32. S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter. Nieto, N., Cederbaum, A.I. J. Biol. Chem. (2005) [Pubmed]
  33. Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62. Kuusisto, E., Parkkinen, L., Alafuzoff, I. J. Neuropathol. Exp. Neurol. (2003) [Pubmed]
  34. Age-related amyloid beta protein accumulation induces cellular death and macrophage activation in transgenic mice. Shoji, M., Kawarabayashi, T., Sato, M., Sasaki, A., Saido, T.C., Matsubara, E., Tomidokoro, Y., Kanai, M., Shizuka, M., Ishiguro, K., Ikeda, M., Harigaya, Y., Okamoto, K., Hirai, S. J. Pathol. (2000) [Pubmed]
  35. Gastrin cell immunofluorescence in conventionally fixed and stained tissue sections. Weinstein, W.M., Lechago, J. Gastroenterology (1977) [Pubmed]
  36. Alterations of myoelectric activity associated with Campylobacter jejuni and its cell-free filtrate in the small intestine of rabbits. Sninsky, C.A., Ramphal, R., Gaskins, D.J., Goldberg, D.A., Mathias, J.R. Gastroenterology (1985) [Pubmed]
  37. Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy. Deerinck, T.J., Martone, M.E., Lev-Ram, V., Green, D.P., Tsien, R.Y., Spector, D.L., Huang, S., Ellisman, M.H. J. Cell Biol. (1994) [Pubmed]
  38. Injections of blood, thrombin, and plasminogen more severely damage neonatal mouse brain than mature mouse brain. Xue, M., Del Bigio, M.R. Brain Pathol. (2005) [Pubmed]
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