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Disease relevance of Flaviviridae


High impact information on Flaviviridae

  • Novel sequences related to members of the Flaviviridae were identified in sera from 12 individuals including 4 individuals with hepatitis [6].
  • The same preference for cytidine in the 3'-terminal dinucleotide was noted in reports of the in vitro activity of the RNA-dependent RNA polymerase (RdRp) for the other genera of Flaviviridae that also employ a double-stranded RNA (dsRNA) template to initiate asymmetric semiconservative RNA positive-strand synthesis [7].
  • However, the kinetic analysis of NTPase activity showed that the MBP-HGV/NS3 protein had several unique properties compared to the other Flaviviridae NS3 proteins [8].
  • Characterization of the ATPase and RNA helicase activities of MBP-HGV/NS3 showed that the optimal reaction conditions were similar to those of other Flaviviridae viral NS3 proteins [8].
  • The NS5A/NS5 proteins of viruses from three genera of the family flaviviridae are phosphorylated by associated serine/threonine kinases [9].

Chemical compound and disease context of Flaviviridae


Gene context of Flaviviridae


Analytical, diagnostic and therapeutic context of Flaviviridae


  1. Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Agnello, V., Abel, G., Elfahal, M., Knight, G.B., Zhang, Q.X. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity. Chang, H.M., Paulson, M., Holko, M., Rice, C.M., Williams, B.R., Marié, I., Levy, D.E. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus. Lackner, T., Müller, A., Pankraz, A., Becher, P., Thiel, H.J., Gorbalenya, A.E., Tautz, N. J. Virol. (2004) [Pubmed]
  4. Fc gamma RII-dependent sensitisation of natural interferon-producing cells for viral infection and interferon-alpha responses. Balmelli, C., Vincent, I.E., Rau, H., Guzylack-Piriou, L., McCullough, K., Summerfield, A. Eur. J. Immunol. (2005) [Pubmed]
  5. Complex processing and protein:protein interactions in the E2:NS2 region of HCV. Selby, M.J., Glazer, E., Masiarz, F., Houghton, M. Virology (1994) [Pubmed]
  6. Isolation of novel virus-like sequences associated with human hepatitis. Simons, J.N., Leary, T.P., Dawson, G.J., Pilot-Matias, T.J., Muerhoff, A.S., Schlauder, G.G., Desai, S.M., Mushahwar, I.K. Nat. Med. (1995) [Pubmed]
  7. Significance in replication of the terminal nucleotides of the flavivirus genome. Khromykh, A.A., Kondratieva, N., Sgro, J.Y., Palmenberg, A., Westaway, E.G. J. Virol. (2003) [Pubmed]
  8. RNA-Stimulated ATPase and RNA helicase activities and RNA binding domain of hepatitis G virus nonstructural protein 3. Gwack, Y., Yoo, H., Song, I., Choe, J., Han, J.H. J. Virol. (1999) [Pubmed]
  9. The NS5A/NS5 proteins of viruses from three genera of the family flaviviridae are phosphorylated by associated serine/threonine kinases. Reed, K.E., Gorbalenya, A.E., Rice, C.M. J. Virol. (1998) [Pubmed]
  10. Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication. Xu, J., Mendez, E., Caron, P.R., Lin, C., Murcko, M.A., Collett, M.S., Rice, C.M. J. Virol. (1997) [Pubmed]
  11. Effect of antimetabolite immunosuppressants on Flaviviridae, including hepatitis C virus. Stangl, J.R., Carroll, K.L., Illichmann, M., Striker, R. Transplantation (2004) [Pubmed]
  12. Polystyrene derivatives substituted with arginine interact with Babanki (Togaviridae) and Kedougou (Flaviviridae) viruses. Imbert-Laurenceau, E., Crepinior, J., Crance, J.M., Jouan, A., Migonney, V. J. Med. Virol. (2003) [Pubmed]
  13. Synthesis and biological activity of 1H-benzotriazole and 1H-benzimidazole analogues--inhibitors of the NTpase/helicase of HCV and of some related Flaviviridae. Bretner, M., Baier, A., Kopańska, K., Najda, A., Schoof, A., Reinholz, M., Lipniacki, A., Piasek, A., Kulikowski, T., Borowski, P. Antivir. Chem. Chemother. (2005) [Pubmed]
  14. Conformational changes of the flavivirus E glycoprotein. Zhang, Y., Zhang, W., Ogata, S., Clements, D., Strauss, J.H., Baker, T.S., Kuhn, R.J., Rossmann, M.G. Structure (Camb.) (2004) [Pubmed]
  15. Internal processing of hepatitis C virus NS3 protein. Shoji, I., Suzuki, T., Sato, M., Aizaki, H., Chiba, T., Matsuura, Y., Miyamura, T. Virology (1999) [Pubmed]
  16. Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes. Suzich, J.A., Tamura, J.K., Palmer-Hill, F., Warrener, P., Grakoui, A., Rice, C.M., Feinstone, S.M., Collett, M.S. J. Virol. (1993) [Pubmed]
  17. The sequence and genomic organization of a GB virus A variant isolated from captive tamarins. Leary, T.P., Desai, S.M., Erker, J.C., Mushahwar, I.K. J. Gen. Virol. (1997) [Pubmed]
  18. Hepatitis C virus infection as an opportunistic disease in persons infected with human immunodeficiency virus. Sulkowski, M.S., Mast, E.E., Seeff, L.B., Thomas, D.L. Clin. Infect. Dis. (2000) [Pubmed]
  19. Flaviviridae polymerase and RNA replication. Bartholomeusz, A., Thompson, P. J. Viral Hepat. (1999) [Pubmed]
  20. Sequence and genomic organization of GBV-C: a novel member of the flaviviridae associated with human non-A-E hepatitis. Leary, T.P., Muerhoff, A.S., Simons, J.N., Pilot-Matias, T.J., Erker, J.C., Chalmers, M.L., Schlauder, G.G., Dawson, G.J., Desai, S.M., Mushahwar, I.K. J. Med. Virol. (1996) [Pubmed]
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