High impact information on Thymelaeaceae

• Active principles of the thymelaeaceae. III. Skin irritant and cocarcinogenic factors from Pimelea simplex [1].
• Four new 2-(2-phenylethyl)chromone derivatives from withered wood of Aquilaria sinensis [2].
• Five compounds, 1-5, were isolated from the seed hexane extract of Dirca palustris [3].
• Six compounds have been isolated from the methanol extract of the aerial parts of Gnidia involucrata (Thymelaeaceae) [4].
• Five novel phenolic glycosides (1-5) were isolated from the MeOH extract of the dried twigs of Dirca palustris, as confirmed by their (1)H NMR, (13)C NMR, and MS data [5].

Associations of Thymelaeaceae with chemical compounds

• Studies in the thymelaeaceae, V. 2'-Hydroxyflavone from Daphnopsis sellowiana: isolation and synthesis [6].
• Bioassay-directed isolation of the antitumor extract of Wikstroemia indica (Thymelaeaceae) has led to the characterization of tricin, kaempferol-3-O-beta-D-glucopyranoside, and (+)-nortrachelogenin as the major antileukemic constituents [7].
• One of most potent leads was an extract derived from Dirca occidentalis Gray (Thymelaeaceae) (ED50, 0.14 micrograms/ml), and bioassay-guided fractionation led to the identification of genkwanin (I), (+/-)-lariciresinol (II) and sitoindoside II (IV) as active principles, with ED50 values of 18.3, 1.1 and 0.069 microM, respectively [8].
• Brief discussions of a number of examples: aconite, ergot, Euphorbiaceae/Thymelaeaceae, curare, cardiac glycosides, triterpenoid saponins and animal toxins, make the point that, in addition to allowing their use as medicinal agents, the study of such substances has opened up new areas of (bio)chemistry, physiology and pharmacology [9].
• A new lignan, (+)-nortrachelogenin (I), and a known compound, daphnoretin were isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae) [10].

References