The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Tricin     5,7-dihydroxy-2-(4-hydroxy- 3,5-dimethoxy...

Synonyms: AC1NQYXG, SureCN44475, CHEMBL454320, AG-F-76904, CHEBI:59979, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Tricin

 

High impact information on Tricin

  • Preincubation of MDA-MB-468 cells with tricin (1-40 microM) for 72 h compromised cell growth after tricin removal, and such irreversibility was not observed in human breast-derived nonmalignant HBL-100 cells [1].
  • Steady-state levels of tricin in plasma, breast tumour tissue and intestinal mucosa, as measured by HPLC, were 0.13 microM and 0.11 and 63 nmol g(-1), respectively [1].
  • Tricin (>/=5 microM) arrested MDA-MB-468 cells in the G2/M phase of the cell cycle without inducing apoptosis as adjudged by annexin V staining [1].
  • As part of the exploration of tricin as a potential cancer chemopreventive agent, we investigated the duration and cell cycle specificity of growth inhibition elicited by tricin in vitro and the effect of tricin on the development of MDA-MB-468 tumours grown in immune-compromised MF-1 mice in vivo [1].
  • While the results do not support the notion that tricin is a promising candidate for breast cancer chemoprevention, its high levels in the gastrointestinal tract after dietary intake render exploration of its ability to prevent colorectal carcinogenesis propitious [1].
 

Chemical compound and disease context of Tricin

 

Anatomical context of Tricin

  • Consumption of diet mixed with tricin at 0.05, 0.2 or 0.5% for one week furnished steady-state levels in plasma, liver and small intestine in the 1--3 x 10(-7), 4--22 x 10(-7) and 3--46 x 10(-5) m ranges, respectively [6].
 

Associations of Tricin with other chemical compounds

 

Gene context of Tricin

  • The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice [4].
  • COX-2 expression was reduced by tricin weakly in HCEC and unaffected in HCA-7 cells [4].
  • P-glycoprotein inhibitory activity of two phenolic compounds, (-)-syringaresinol and tricin from Sasa borealis [5].
 

Analytical, diagnostic and therapeutic context of Tricin

  • The ability of tricin (50 microM) to cleave the MLL gene was studied in human leukaemia cells by Southern blotting, and its effect on human topoisomerase II activity was investigated in incubations with supercoiled DNA [2].
  • Determination of the flavone tricin in human plasma by high-performance liquid chromatography [3].

References

  1. Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo. Cai, H., Hudson, E.A., Mann, P., Verschoyle, R.D., Greaves, P., Manson, M.M., Steward, W.P., Gescher, A.J. Br. J. Cancer (2004) [Pubmed]
  2. Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone. Verschoyle, R.D., Greaves, P., Cai, H., Borkhardt, A., Broggini, M., D'Incalci, M., Riccio, E., Doppalapudi, R., Kapetanovic, I.M., Steward, W.P., Gescher, A.J. Cancer Chemother. Pharmacol. (2006) [Pubmed]
  3. Determination of the flavone tricin in human plasma by high-performance liquid chromatography. Cai, H., Verschoyle, R.D., Steward, W.P., Gescher, A.J. Biomed. Chromatogr. (2003) [Pubmed]
  4. The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice. Cai, H., Al-Fayez, M., Tunstall, R.G., Platton, S., Greaves, P., Steward, W.P., Gescher, A.J. Mol. Cancer Ther. (2005) [Pubmed]
  5. P-glycoprotein inhibitory activity of two phenolic compounds, (-)-syringaresinol and tricin from Sasa borealis. Jeong, Y.H., Chung, S.Y., Han, A.R., Sung, M.K., Jang, D.S., Lee, J., Kwon, Y., Lee, H.J., Seo, E.K. Chem. Biodivers. (2007) [Pubmed]
  6. Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV--visible detection. Cai, H., Steward, W.P., Gescher, A.J. Biomed. Chromatogr. (2005) [Pubmed]
  7. Flavonoids from Barrel Medic (Medicago truncatula) Aerial Parts. Kowalska, I., Stochmal, A., Kapusta, I., Janda, B., Pizza, C., Piacente, S., Oleszek, W. J. Agric. Food Chem. (2007) [Pubmed]
  8. A simple HPLC method for the determination of apigenin in mouse tissues. Cai, H., Raynaud, D., Steward, W.P., Gescher, A.J. Biomed. Chromatogr. (2006) [Pubmed]
  9. Flavonoid concentrations in three grass species and a sedge grown in the field and under controlled environment conditions in response to enhanced UV-B radiation. van de Staaij, J., de Bakker, N.V., Oosthoek, A., Broekman, R., van Beem, A., Stroetenga, M., Aerts, R., Rozema, J. J. Photochem. Photobiol. B, Biol. (2002) [Pubmed]
  10. Confirmation of potential herbicidal agents in hulls of rice, Oryza sativa. Chung, I.M., Hahn, S.J., Ahmad, A. J. Chem. Ecol. (2005) [Pubmed]
  11. Antioxidative phenolic compounds from Japanese barnyard millet (Echinochloa utilis) grains. Watanabe, M. J. Agric. Food Chem. (1999) [Pubmed]
 
WikiGenes - Universities