Disease relevance of Gynostemma

• Gypenosides (Gyp) are triterpenoid saponins contained in an extract from Gynostemma pentaphyllum Makino and reported to induce apoptosis in human hepatoma cells [1].

High impact information on Gynostemma

• Three dammarane-type saponins from Gynostemma pentaphyllum [2].
• Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-kappaB-mediated iNOS protein expression [3].
• Gypenosides are triterpenoid saponins contained in an extract from Gynostemma pentaphyllum and are reported to be effective in the treatment of cardiovascular diseases; however, the mechanism underlying the therapeutic effect is not known [4].
• Three new dammarane glycosides (1-3), together with five known compounds, gypenoside LXIX (4), gylongiposide I (5), gypenoside XLVIII (6), allantion (7) and vitexin (8) were isolated from the MeOH extract of the aerial parts of Gynostemma pentaphyllum [5].
• Antimutagenicity and DT-diaphorase inducing activity of Gynostemma pentaphyllum Makino extract [6].

Associations of Gynostemma with chemical compounds

• Gycomoside I: a new dammarane saponin from Gynostemma compressum [7].
• Preliminary studies indicate Gynostemma isolated triterpine glycosides lower cholesterol [8].
• The administration of Gynostemma pentaphyllum displayed an activity even more potent than indomethacin [9].

Gene context of Gynostemma

• Gynostemma had no effect on LL, however, it reversed the P407 inhibition of LPL activity in a concentration-dependent manner, with a 2-fold increase at approximately 10 microg/ml [8].

References