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Chemical Compound Review

Vitexin     5,7-dihydroxy-2-(4- hydroxyphenyl)-8-[(2R...

Synonyms: SureCN25277, CHEMBL487417, AG-L-67047, CHEBI:16954, AC-6086, ...
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Disease relevance of Vitexin


High impact information on Vitexin

  • Twenty-four female Wistar rats, divided into groups of six rats each and fed Purina iodine-rich diet (12 micrograms I-/day.rat), were administered acutely by gastrointestinal tube goitrogen-free water (controls), methimazole (0.5 mumol), and vitexin (20 and 80 mumol) [2].
  • Three C-glycosylflavones present in millet, glucosylvitexin, glycosylorientin, and vitexin, also inhibited TPO activity [3].
  • The optimum parameters for adsorption were as follows: the concentration of vitexin and isovitexin in sample solution: 0.22 and 0.40mg/mL, respectively, processing volume: 3 BV, flow rate: 1mL/min, pH 4, temperature: 25 degrees C; for desorption: ethanol-water (40:60, v/v), 5 BV as an eluent, flow rate: 1mL/min [4].
  • Three flavonoid glycosides including orientin, vitexin, quercetin-3-O-neohesperidoside and one unknown compound were isolated and purified by high-speed counter-current chromatography (HSCCC) and semi-preparative HPLC from Trollius ledebouri Reichb., a traditional Chinese medicine [5].
  • At 400 microg/kg, schaftoside (6-C-beta-glucopyranosyl-8-C-alpha-arabinopyranosylapigenin) and vitexin (8-C-beta-glucopyranosylapigenin), isolated from EI, inhibited 62% and 80% of lung neutrophil influx, respectively [6].

Biological context of Vitexin


Anatomical context of Vitexin


Associations of Vitexin with other chemical compounds


Gene context of Vitexin

  • The isolation and antioxidative effects of vitexin from Acer palmatum [10].


  1. Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge. Li, Y.L., Ma, S.C., Yang, Y.T., Ye, S.M., But, P.P. Journal of ethnopharmacology. (2002) [Pubmed]
  2. Antithyroid effects in vivo and in vitro of vitexin: a C-glucosylflavone in millet. Gaitan, E., Cooksey, R.C., Legan, J., Lindsay, R.H. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  3. Antithyroid and goitrogenic effects of millet: role of C-glycosylflavones. Gaitan, E., Lindsay, R.H., Reichert, R.D., Ingbar, S.H., Cooksey, R.C., Legan, J., Meydrech, E.F., Hill, J., Kubota, K. J. Clin. Endocrinol. Metab. (1989) [Pubmed]
  4. Preparative separation of vitexin and isovitexin from pigeonpea extracts with macroporous resins. Fu, Y., Zu, Y., Liu, W., Hou, C., Chen, L., Li, S., Shi, X., Tong, M. Journal of chromatography. A (2007) [Pubmed]
  5. Isolation and purification of flavonoid glycosides from Trollius ledebouri using high-speed counter-current chromatography by stepwise increasing the flow-rate of the mobile phase. Zhou, X., Peng, J., Fan, G., Wu, Y. Journal of chromatography. A. (2005) [Pubmed]
  6. C-glycosylflavones from the aerial parts of Eleusine indica inhibit LPS-induced mouse lung inflammation. De Melo, G.O., Muzitano, M.F., Legora-Machado, A., Almeida, T.A., De Oliveira, D.B., Kaiser, C.R., Koatz, V.L., Costa, S.S. Planta Med. (2005) [Pubmed]
  7. Hepatoprotective effect of Combretum quadrangulare and its constituents. Banskota, A.H., Tezuka, Y., Adnyana, I.K., Xiong, Q., Hase, K., Tran, K.Q., Tanaka, K., Saiki, I., Kadota, S. Biol. Pharm. Bull. (2000) [Pubmed]
  8. Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents. Hajdú, Z., Hohmann, J., Forgo, P., Martinek, T., Dervarics, M., Zupkó, I., Falkay, G., Cossuta, D., Máthé, I. Phytotherapy research : PTR (2007) [Pubmed]
  9. Vitexin, an HIF-1alpha Inhibitor, Has Anti-metastatic Potential in PC12 Cells. Choi, H.J., Eun, J.S., Kim, B.G., Kim, S.Y., Jeon, H., Soh, Y. Mol. Cells (2006) [Pubmed]
  10. The isolation and antioxidative effects of vitexin from Acer palmatum. Kim, J.H., Lee, B.C., Kim, J.H., Sim, G.S., Lee, D.H., Lee, K.E., Yun, Y.P., Pyo, H.B. Arch. Pharm. Res. (2005) [Pubmed]
  11. Production of Flavonoids in Cell Cultures of Crataegus monogyna. Kartnig, T., Kögl, G., Heydel, B. Planta Med. (1993) [Pubmed]
  12. Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine: vitexin 2"-O-rhamnoside 7-O-methyltransferase of Avena sativa L. Knogge, W., Weissenböck, G. Eur. J. Biochem. (1984) [Pubmed]
  13. Optimization of "Askoeziuofito" tablets. Savickas, A., Bernatoniene, J. Medicina (Kaunas, Lithuania) (2005) [Pubmed]
  14. Kakispyrol, a new biphenyl derivative from the leaves of Diospyros kaki. Chen, G., Xu, S.X., Wang, H.Z., Zhang, R.Q. Journal of Asian natural products research. (2005) [Pubmed]
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