Disease relevance of Vitexin

• The antiviral activities of the crude extract, total flavonoids, orientin, vitexin and proglobeflowery acid isolated from the flowers of T. chinensis against parainfluenza type 3 (Para 3) virus were investigated [1].

High impact information on Vitexin

• Twenty-four female Wistar rats, divided into groups of six rats each and fed Purina iodine-rich diet (12 micrograms I-/day.rat), were administered acutely by gastrointestinal tube goitrogen-free water (controls), methimazole (0.5 mumol), and vitexin (20 and 80 mumol) [2].
• Three C-glycosylflavones present in millet, glucosylvitexin, glycosylorientin, and vitexin, also inhibited TPO activity [3].
• The optimum parameters for adsorption were as follows: the concentration of vitexin and isovitexin in sample solution: 0.22 and 0.40mg/mL, respectively, processing volume: 3 BV, flow rate: 1mL/min, pH 4, temperature: 25 degrees C; for desorption: ethanol-water (40:60, v/v), 5 BV as an eluent, flow rate: 1mL/min [4].
• Three flavonoid glycosides including orientin, vitexin, quercetin-3-O-neohesperidoside and one unknown compound were isolated and purified by high-speed counter-current chromatography (HSCCC) and semi-preparative HPLC from Trollius ledebouri Reichb., a traditional Chinese medicine [5].
• At 400 microg/kg, schaftoside (6-C-beta-glucopyranosyl-8-C-alpha-arabinopyranosylapigenin) and vitexin (8-C-beta-glucopyranosylapigenin), isolated from EI, inhibited 62% and 80% of lung neutrophil influx, respectively [6].

Biological context of Vitexin

• Methyl quadrangularates A (30) and N (32), norquadrangularic acid B (31) and vitexin (40) also showed potent inhibition on TNF-alpha-induced cell death with IC50 values of 45.7, 89.3, 67.6 and 40.1 microM, respectively [7].
• The main flavonoid constituents of the EtOAc extract, casticin, vitexin and orientin were assayed for antioxidant activity and found that only casticin possesses a marked lipid peroxidation inhibitory effect (IC(50) = 0.049 mm) compared with that of the positive control ascorbic acid (IC(50) = 0.703 mm) [8].

Anatomical context of Vitexin

• Vitexin inhibited HIF-1a in PC12 cells, but not in HOS or HepG2 cells [9].
• Intracellular ROS scavenging activity was indicated by increases in dichlorofluorescein (DCF) fluorescence upon exposure to UVB 20 mJ/cm2 in cultured human dermal fibroblasts (HDFs) after the treatment of vitexin [10].
• We found that vitexin inhibited the migration of PC12 cells as well as their invasion rates, and it also inhibited tube formation by human umbilical vein endothelium cells (HUVECs) [9].

Associations of Vitexin with other chemical compounds

• The flavonoid glycosides vitexin, vitexin 2- O-rhamnoside, rutin, and hyperoside, as well as the aglycones apigenin, luteolin, and quercetin, could be detected by TLC and HPLC in, however, varying amounts [11].
• Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine: vitexin 2"-O-rhamnoside 7-O-methyltransferase of Avena sativa L [12].
• Flavonoids (quercetin, quercitrin, kempferol, hyperoside, vitexin, luteolin) were identified by method of high-pressure liquid chromatography; caffeic and ascorbic acids were identified by method of thin layer chromatography; and hydroxycinnamonic acids -- by method of spectrophotometry [13].
• A new biphenyl derivative, 4',5-dimethoxy-3-beta-D-glucopyranosyloxy-4-hydroxy-biphenyl, named kakispyrol (1), has been isolated from the leaves of Diospyros kaki, together with three known compounds, vitexin (2), 2'-O-rhamnosyl vitexin (3) and isorhamnetin-3-O-beta-D-glucopyranoside (4) [14].
• Vitexin, an HIF-1alpha Inhibitor, Has Anti-metastatic Potential in PC12 Cells [9].

Gene context of Vitexin

• The isolation and antioxidative effects of vitexin from Acer palmatum [10].

References