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MeSH Review

Research Subjects

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High impact information on Research Subjects

  • RESULTS: Large proportions of potential research subjects were excluded under most of the criteria tested [1].
  • This low radiation burden will allow more than 370 MBq (10 mCi) to be administered to healthy research subjects during each study of the D2 receptor [2].
  • Male research subjects were administered placebo and three doses of d-amphetamine (5, 10 and 20 mg/70 kg) in a laboratory situation which provided both aggressive and non-aggressive response options [3].
  • The effects of ethanol on cigarette smoking were assessed in volunteer research subjects who had histories of light to moderate social drinking [4].
  • In the present study, we combined acute immediate-release (IR) isradipine with repeated sustained-release (SR) isradipine pretreatment to determine whether isradipine could antagonize methamphetamine's positive subjective and reinforcing effects in methamphetamine-dependent research subjects [5].

Biological context of Research Subjects


Associations of Research Subjects with chemical compounds


Gene context of Research Subjects

  • Human subjects research. Pediatric study of ADHD drug draws high-level public review [11].
  • Subjects were 100 patients who had previously sustained moderate-to-severe TBI who were enrolled as research subjects in the UCLA Brain Injury Research Center, and 30 matched control subjects who had sustained traumatic injuries other than to the head six months prior to evaluation [12].
  • How to interpret the federal policy for the protection of human subjects or "Common Rule" (Part A). [for the Working Group of the Human Subjects Research Subcommittee of the National Science and Technology Council.] [13].
  • Children have been used as research subjects in a diverse set of experiments, including the trials of new vaccines and sera, in efforts to understand normal pediatric anatomy and physiology and in the development of new drugs and procedures [14].
  • The majority of the research subjects who scored between 400 and 500 on the TOEFL achieved a grade level of less than 8.0 on the California Achievement Test [15].

Analytical, diagnostic and therapeutic context of Research Subjects


  1. Use of exclusion criteria in selecting research subjects and its effect on the generalizability of alcohol treatment outcome studies. Humphreys, K., Weisner, C. The American journal of psychiatry. (2000) [Pubmed]
  2. Biodistribution and dosimetry of iodine-123-IBF: a potent radioligand for imaging the D2 dopamine receptor. Mozley, P.D., Stubbs, J.B., Kung, H.F., Selikson, M.H., Stabin, M.G., Alavi, A. J. Nucl. Med. (1993) [Pubmed]
  3. Effects of d-amphetamine on human aggressive behavior. Cherek, D.R., Steinberg, J.L., Kelly, T.H., Robinson, D.E. Psychopharmacology (Berl.) (1986) [Pubmed]
  4. Effects of ethanol on cigarette smoking by volunteers without histories of alcoholism. Henningfield, J.E., Chait, L.D., Griffiths, R.R. Psychopharmacology (Berl.) (1984) [Pubmed]
  5. Effects of isradipine, a dihydropyridine-class calcium-channel antagonist, on d-methamphetamine's subjective and reinforcing effects. Johnson, B.A., Roache, J.D., Ait-Daoud, N., Wallace, C., Wells, L., Dawes, M., Wang, Y. Int. J. Neuropsychopharmacol. (2005) [Pubmed]
  6. Isolation and characterization of beta-catenin downstream genes in early embryos of the ascidian Ciona savignyi. Imai, K.S. Differentiation (2003) [Pubmed]
  7. 12-lead and continuous ECG recordings of subjects during inpatient administration of smoked cocaine. Pentel, P.R., Thompson, T., Hatsukami, D.K., Salerno, D.M. Drug and alcohol dependence. (1994) [Pubmed]
  8. Normocapnia improves cerebral oxygen delivery during conventional oxygen therapy in carbon monoxide-exposed research subjects. Rucker, J., Tesler, J., Fedorko, L., Takeuchi, A., Mascia, L., Vesely, A., Kobrossi, S., Slutsky, A.S., Volgyesi, G., Iscoe, S., Fisher, J.A. Annals of emergency medicine. (2002) [Pubmed]
  9. Marginal utility of montelukast for persistent asthma. Mathison, D.A., Koziol, J.A. Chest (2002) [Pubmed]
  10. Famotidine treatment of children with autistic spectrum disorders: pilot research using single subject research design. Linday, L.A., Tsiouris, J.A., Cohen, I.L., Shindledecker, R., DeCresce, R. Journal of neural transmission (Vienna, Austria : 1996) (2001) [Pubmed]
  11. Human subjects research. Pediatric study of ADHD drug draws high-level public review. Couzin, J. Science (2004) [Pubmed]
  12. Depression, cognition, and functional correlates of recovery outcome after traumatic brain injury. Satz, P., Forney, D.L., Zaucha, K., Asarnow, R.R., Light, R., McCleary, C., Levin, H., Kelly, D., Bergsneider, M., Hovda, D., Martin, N., Namerow, N., Becker, D. Brain injury : [BI]. (1998) [Pubmed]
  13. How to interpret the federal policy for the protection of human subjects or "Common Rule" (Part A). [for the Working Group of the Human Subjects Research Subcommittee of the National Science and Technology Council.]. Shelton, J.D. IRB (1999) [Pubmed]
  14. Children as guinea pigs: historical perspective. Lederer, S.E. Accountability in research. (2003) [Pubmed]
  15. Using the TOEFL to measure the reading proficiency levels of deaf college applicants. LoMaglio, L.J. American annals of the deaf. (1991) [Pubmed]
  16. 'Research' versus 'real-world' patients: representativeness of participants in clinical trials of treatments for cocaine dependence. Carroll, K.M., Nich, C., McLellan, A.T., McKay, J.R., Rounsaville, B.J. Drug and alcohol dependence. (1999) [Pubmed]
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