Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

MeSH Review:

AKR murine leukemia virus

Rappaport, I. et al., Chattopadhyay, S. et al., Massey, A.C. et al., Sithanandam, G. et al., O'Neill, H.C. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AKR murine leukemia virus

Specificity for viral Mr 70,000 glycoprotein-related antigens was indicated by absorption of antibody activity by endogenous AKR virus and by inhibition of antibody binding to B16 melanoma cells by monospecific antiserum to murine leukemia virus Mr 70,000 glycoprotein [1].
The AKR-derived T cell lymphomas, SL3 and KKT-2, show greater specificity for leukemogenic AKR viruses, than for an AKR xenotropic virus or the recombinant AKR virus, MCF247 [2].

High impact information on AKR murine leukemia virus

Using a [3H]DNA probe prepared from AKR murine leukemia virus, we determined the number of copies of the AKR virus genome integrated into the cellular DNA after exogenous infection of NIH mouse, AKR mouse, and rat cells in tissue culture [3].
In addition, the U3 region of CWM-S-5X contained a viral enhancer sequence that was identical to that found in MCF 247, a recombinant AKR virus that is thought to contain the Bxv-1 enhancer [4].
Fragment exchange between the XC-negative molecular clone p110 and the XC-positive AKR virus clone p623 revealed that the defect in p110 lies 3' of the SalI site located in the pol region [5].
Upon growth in certain mouse cells these replication-deficient, XC(-) viruses converted to type C viruses that were similar in XC assays to N-tropic AKR virus (XC+) [6].
Endogenous DNA synthesis by AKR virus particles was inhibited by novobiocin to the same extent [7].

References

Syngeneic monoclonal antibodies to B16 melanoma viral antigens. Rappaport, I., Alterman, A.L., Braverman, S., Stackpole, C.W. Cancer Res. (1987) [Pubmed]
Measurement of binding specificity between T cell lymphomas and murine leukemia viruses. O'Neill, H.C., Weissman, I.L. J. Immunol. Methods (1989) [Pubmed]
Quantitative studies of integration of murine leukemia virus after exogenous infection. Chattopadhyay, S., Rowe, W.P., Levine, A.S. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
Origin of pathogenic determinants of recombinant murine leukemia viruses: analysis of Bxv-1-related xenotropic viruses from CWD mice. Massey, A.C., Coppola, M.A., Thomas, C.Y. J. Virol. (1990) [Pubmed]
A single point mutation in the envelope gene is responsible for replication and XC fusion deficiency of the endogenous ecotropic C3H/He murine leukemia virus and for its repair in culture. Sithanandam, G., Rapp, U.R. J. Virol. (1988) [Pubmed]
Endogenous ecotropic mouse type C viruses deficient in replication and production of XC plaques. Rapp, U.R., Nowinski, R.C. J. Virol. (1976) [Pubmed]
Inhibition of retrovirus RNA-dependent DNA polymerase by novobiocin and nalidixic acid. Sumiyoshi, Y., Nishikawa, T., Watanabe, T., Kano, K. J. Gen. Virol. (1983) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share