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Gene Review

Emv2  -  endogenous ecotropic MuLV 2

Mus musculus

Synonyms: Blv-1, Bv-1, Emv-2, Inb-1, N-tropic
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Disease relevance of Emv2

  • MelARV probably emerged as a result of recombination between Emv-2 and an endogenous nonecotropic provirus [1].
  • Loss of Fv-1 restriction in Balb/3T3 cells following infection with a single N tropic murine leukemia virus particle [2].
  • The subject of this study was to test whether in vivo thymocytes in the preleukemic and leukemic periods also bear receptors specific for N-tropic, recombinant MCF and SL AKR retroviruses [3].
  • The pseudotype prepared with MuLV-RF or another NB-tropic MuLV-F, but not the virus obtained by rescue with N-tropic MuLV-F, induced erythroleukemia that spontaneously regressed [4].
  • After infecting these mice with N-tropic FV complex, we followed the replication of spleen focus-forming virus (SFFV) and the generation of SFFV-transformed tumor colony-forming cells (CFC) in their spleens [5].

High impact information on Emv2

  • Examination of hybrids of BALB/c and of B6 with other strains indicates that strains related in pedigree to BALB/c carry Inc-1, whereas those related to B6 carry Inb-1 [6].
  • AKR mice regularly begin expressing N-tropic retroviruses (as assayed on NIH fibroblasts by the XC plaque assay) in several tissues early in life; thymic lymphocytes also express these viruses, but are not autonomously transformed [3].
  • The resulting dose-response curves indicate that productive infection of a single Balb/3T3 cell with N tropic MSV requires co-infection with two MuLV particles [2].
  • These observations suggested that neuropathogenic strains of LDV elicit the disease only in those strains of mice that carry multiple copies of N-tropic C-type retroviruses in their genomes and that are permissive for retrovirus replication [7].
  • Previously, we identified two genes, termed Inc-1 and Inb-1, that interact to enhance ecotropic murine leukemia virus induction in low virus strains of mice [8].

Chemical compound and disease context of Emv2


Biological context of Emv2

  • Here, we show that mice related to BALB/c in origin, i.e., A, C3H/He, and SEC, have an Inc-1 locus that is allelic with that of BALB/c. The C57BR mouse strain has an Inb-1 locus that is allelic with that of B6, located on chromosome 8, 30 cM from Es-1 [8].
  • Our data show that MelARV has a typical full-length retroviral genome with high homology (98.54%) to Emv-2, indicating a close relationship between both viruses [1].
  • Southern analysis and hybridization with an ecotropic MuLV DNA-specific probe showed that DNA of normal BXH-2 tissues contained both parental N-tropic MuLV proviruses but lacked endogenous B-tropic MuLV DNA sequences [11].
  • In C58 and AKR mice, endogenous N-tropic, ecotropic murine leukemia virus (MuLV) proviruses become activated in rare cells during embryogenesis [12].
  • By typing thymocytes of Fv-1-congenic mice for Ec+ gp70 was found that manifestation of the Ec+ gp70 phenotype requires the Fv-1n allele, which is permissive for replication of N-tropic virus produced by AKR and other virus-producing mouse strains [13].

Anatomical context of Emv2

  • DNA dose-response studies in NIH-3T3 cells revealed a one-hit mechanism for both the [B-tropic MuLV]SC-1 cell DNA and the [N-tropic MuLV]SC-1 cell DNA preparation [14].
  • C57BL/6 (B6) mice injected with B- or NB-fibrotropic clones, but not with TV or N-tropic viral clones, developed reactive T lymphocytes (Tr), capable of differentiating into anti-tumor cytotoxic cells [15].

Associations of Emv2 with chemical compounds


Other interactions of Emv2


Analytical, diagnostic and therapeutic context of Emv2


  1. Sequence and insertion sites of murine melanoma-associated retrovirus. Li, M., Huang, X., Zhu, Z., Gorelik, E. J. Virol. (1999) [Pubmed]
  2. Loss of Fv-1 restriction in Balb/3T3 cells following infection with a single N tropic murine leukemia virus particle. Duran-Troise, G., Bassin, R.H., Rein, A., Gerwin, B.I. Cell (1977) [Pubmed]
  3. AKR leukemogenesis: identification and biological significance of thymic lymphoma receptors for AKR retroviruses. McGrath, M.S., Weissman, I.L. Cell (1979) [Pubmed]
  4. Spontaneous regression of Friend virus-induced erythroleukemia. I. The role of the helper murine leukemia virus component. Dietz, M., Fouchey, S.P., Longley, C., Rich, M.A., Furmanski, P. J. Exp. Med. (1977) [Pubmed]
  5. The Fv-2r resistance gene in mice: its effect on spleen colony formation by Friend virus-transformed cells. Blank, K.J., Steeves, R.A., Lilly, F. J. Natl. Cancer Inst. (1976) [Pubmed]
  6. Genetic interactions in induction of endogenous murine leukemia virus from low leukemic mice. McCubrey, J., Risser, R. Cell (1982) [Pubmed]
  7. Co-infection by lactic dehydrogenase virus and C-type retrovirus elicits neurological disease. Pease, L.R., Murphy, W.H. Nature (1980) [Pubmed]
  8. Allelism and linkage studies of murine leukemia virus activation genes in low leukemic strains of mice. McCubrey, J., Risser, R. J. Exp. Med. (1982) [Pubmed]
  9. Induction of B-tropic and N-tropic murine leukemia virus from B10.BR/SgLi mouse embryo cell lines by 5-iodo-2'-deoxyuridine. Moll, B., Hartley, J.W., Rowe, W.P. J. Natl. Cancer Inst. (1979) [Pubmed]
  10. In vitro studies of a co-carcinogenic effect of vaccinia and herpes group viruses. Mazurenko, N.P., Merekalova, Z.I., Pavlish, O.A., Bykovsky, A.F., Kurzman, M.J., Mazurenko, N.N. Neoplasma (1981) [Pubmed]
  11. Ecotropic murine leukemia virus DNA content of normal and lymphomatous tissues of BXH-2 recombinant inbred mice. Jenkins, N.A., Copeland, N.G., Taylor, B.A., Bedigian, H.G., Lee, B.K. J. Virol. (1982) [Pubmed]
  12. Expression of ecotropic murine leukemia virus in the brains of C58/M, DBA2/J, and in utero-infected CE/J mice. Anderson, G.W., Plagemann, P.G. J. Virol. (1995) [Pubmed]
  13. Influence of Fv-1 alleles on cellular expression of gp70. Tung, J.S., Boyse, E.A., Shen, F.W. J. Exp. Med. (1980) [Pubmed]
  14. Transfection of Fv-1 permissive and restrictive mouse cells with integrated DNA of murine leukemia viruses. Hsu, I.C., Yang, W.K., Tennant, R.W., Brown, A. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  15. A highly leukemogenic radiation leukemia virus isolate is a thymotropic, immunosuppressive retrovirus with a unique RNA structure. Ben David, Y., Kotler, M., Yefenof, E. Int. J. Cancer (1987) [Pubmed]
  16. Analysis of Fv-1 restriction in two murine embryonal carcinoma cell lines and a series of differentiated derivatives. Heitman, C.K., Innes, C.L., Jetten, A.M., Boone, L.R. J. Gen. Virol. (1991) [Pubmed]
  17. Genetic control of myeloproliferation in BXH-2 mice. Turcotte, K., Gauthier, S., Mitsos, L.M., Shustik, C., Copeland, N.G., Jenkins, N.A., Fournet, J.C., Jolicoeur, P., Gros, P. Blood (2004) [Pubmed]
  18. Linkage of Agt and Actsk-1 to distal mouse chromosome 8 loci: a new conserved linkage. Abonia, J.P., Abel, K.J., Eddy, R.L., Elliott, R.W., Chapman, V.M., Shows, T.B., Gross, K.W. Mamm. Genome (1993) [Pubmed]
  19. Nucleotide sequences of gag-pol regions that determine the Fv-1 host range property of BALB/c N-tropic and B-tropic murine leukemia viruses. Ou, C.Y., Boone, L.R., Koh, C.K., Tennant, R.W., Yang, W.K. J. Virol. (1983) [Pubmed]
  20. Fv-1 determinants in xenotropic murine leukemia viruses studied with biological assay systems: Isolation of xenotropic virus with N-tropic Fv-1 activity in the cryptic form. Sakai, K., Narita, H., Adachi, A., Tsuruta, S., Yorifuji, T., Ishimoto, A. J. Virol. (1982) [Pubmed]
  21. Polymorphism of B-tropic leukemia viruses from BALB/c mice: association of a p30 antigen with N- versus B-tropism. Tress, E., O'Donnell, P.V., Famulari, N., Ellis, R.W., Fleissner, E. J. Virol. (1979) [Pubmed]
  22. A single amino acid change in the murine leukemia virus capsid gene responsible for the Fv1(nr) phenotype. Jung, Y.T., Kozak, C.A. J. Virol. (2000) [Pubmed]
  23. Molecular cloning of B- and N-tropic endogenous BALB/c murine leukemia virus circular DNA intermediates: isolation and characterization of infectious recombinant clones. Rassart, E., DesGroseillers, L., Jolicoeur, P. J. Virol. (1981) [Pubmed]
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