Disease relevance of Benzylbenzenecarboxylate

• Benzyl benzoate (BB), which has been widely used to kill scabies mites and is known to kill mites of the genus Dermatophagoides, has been used as a method of treating carpets [1].
• A randomized controlled trial was conducted to test the effect of a sheet impregnated with benzyl benzoate in preventing mite infestation of new bedding [2].
• Ivermectin alone or in combination with benzyl benzoate in the treatment of human immunodeficiency virus-associated scabies [3].
• The efficacy of the acaricide benzyl benzoate as an additive to a chemically and technically defined cleaning substance (Acarosan) was tested in a multicentric, prospective, randomized, controlled study on 118 outpatients with bronchial asthma due to house-dust-mite allergy [4].
• Therefore, we consider that combination treatment with benzyl benzoate solution and oral ivermectin is preferable to single-agent therapy in crusted scabies occurring in HIV/acquired immune deficiency syndrome patients [3].

Psychiatry related information on Benzylbenzenecarboxylate

• In typical poisoning symptoms, butylidenephthalide resulted in lethargy of treated mites, leading to death without knockdown, whereas benzyl benzoate and DEET caused death associated with uncoordinated behaviour [5].

High impact information on Benzylbenzenecarboxylate

• CONCLUSIONS: It is possible to achieve mite control in delicate garments by washing at low temperature in the presence of a mite control additive providing a final concentration of 0.03% benzyl benzoate [6].
• Reported S scabiei treatment failures with lindane, crotamiton, and benzyl benzoate, as well as likely emerging resistance to 5% permethrin and oral ivermectin, are of concern and advocate for the identification and development of novel acaricidal drugs [7].
• In this paper, we investigated the structure formation in a PLGA/benzyl benzoate system, using controlled stress rheometry, gel permeation chromatography (GPC), and differential scanning calorimetry (DSC) [8].
• Squamocin and benzyl benzoate, acaricidal components of Uvaria pauci-ovulata bark extracts [9].
• Mouse embryos were harvested on gestation day 8 or 9 and stained with the vital lysosomal dye, LysoTracker Red. Following incubation in the stain, embryos were fixed in 2% paraformaldehyde overnight, dehydrated in a graded methanol series, and cleared in benzyl alcohol/benzyl benzoate [10].

Chemical compound and disease context of Benzylbenzenecarboxylate

• Neither benzyl benzoate, deet, nor dibutyl phthalate exhibited fumigant toxicity [11].
• Treatment of scabies with disulfiram and benzyl benzoate emulsion: a controlled study [12].
• In a double-blind study, 38 adults with scabies were treated with the scabicide Tenutex (a proprietary aqueous emulsion containing 0.5% DDT, 2% disulfiram and 22.5% benzyl benzoate) and 42 patients were treated with a similar emulsion lacking DDT [12].
• Efficacy and tolerability of a new synergized pyrethrins thermofobic foam in comparison with benzyl benzoate in the treatment of scabies in convicts: the ISAC study (Studio Della scabbia in ambiente carcerario) [13].
• Cost-benefit analysis of ivermectin, permethrin and benzyl benzoate in the management of infantile and childhood scabies [14].

Biological context of Benzylbenzenecarboxylate

• CONCLUSION: Mite control by low temperature washing is possible with a mite control additive provided that a concentration of benzyl benzoate of about 0.03% is achieved in the washing suds [15].
• On the basis of the 50% lethal dose (LD50), the compound most toxic to T. putrescentiae adults was salicylaldehyde (LD50 of 1.02 microg/cm2) followed by cinnamaldehyde (1.66 microg/cm2), benzaldehyde (4.23 microg/cm2), phthaldialdehyde (5.16 microg/cm2), benzyl benzoate (9.75 microg/cm2), and N,N-diethyl-m-toluamide (16.26 micorg/cm2) [16].
• The acaricidal activity of materials derived from the rhizome of Cnidium officinale Makino against Tyrophagus putrescentiae Schrank adults was examined using direct contact application and fumigation methods, and compared with that of benzyl benzoate and N,N-diethyl-m-toluamide (DEET) [5].

Anatomical context of Benzylbenzenecarboxylate

• After location of the radioactive microspheres within the intact oviducts, the genital tracts were removed and cleared in benzyl benzoate [17].
• Effect of castor oil and benzyl benzoate used as a vehicle for antiandrogens on the adrenal cortex [18].
• The alkaline solution method for detecting uterine implantation sites (metrial glands or spots after delivery), which indicate the position of the embryo, was compared with conventional methods using Turnbull blue (Salewski's technique) and benzyl benzoate (Orsini's technique) in rats [19].
• Benzyl benzoate cleared fixed or unfixed uteri and allowed observation of the metrial glands and spots after delivery although the entire process required a few days and the specimens became hard and shriveled [19].

Associations of Benzylbenzenecarboxylate with other chemical compounds

• Control of the human head louse with disulfiram and benzyl benzoate emulsions. A laboratory study [20].
• The activities of benzaldehyde isolated from Prunus persica seeds and of commercially available aldehydes against Tyrophagus putrescentiae (a stored-food mite) adults were examined and compared with those of the synthetic acaricides benzyl benzoate and N,N-diethyl-m-toluamide [16].
• We studied the effect of a spray containing 1% benzyl benzoate, an acaricide, and 1% tannic acid ('Lowal'; a protein-denaturing substance), on concentrations of major allergens from house dust mite (HDM) species Dermatophagoides pteronyssinus and D. farinae (Der p 1 and Der f 1, respectively) in carpets [21].
• Bioguided-fractionation of a CH(2)Cl(2) extract of the stems of Uvaria klaineana (Annonaceae) led to isolation of klaivanolide, a novel bisunsaturated 7-membered lactone (5-acetoxy-7-benzoyloxymethyl-7H-oxepin-2-one), together with benzyl benzoate [22].

Gene context of Benzylbenzenecarboxylate

• It is concluded that for the treatment of scabies in Sweden, the most commonly used preparation, Tenutex, can be replaced, without risk of loss of efficacy, by an emulsion containing 2% disulfiram and 22.5% benzyl benzoate, i.e. Tenutex without DDT [12].
• Crusted scabies associated with systemic lupus erythematosus: response to benzyl benzoate therapy [23].
• Formulations were prepared by dissolving/ suspending CT polypeptide in poly-(lactic acid) (PLA) polymer solutions/suspensions containing combinations of a hydrophobic (benzyl benzoate, BB) and a hydrophilic (benzyl alcohol, BA) solvent [24].

Analytical, diagnostic and therapeutic context of Benzylbenzenecarboxylate

• Clinical effects of benzyl benzoate in the prevention of house-dust-mite allergy. Results of a prospective, double-blind, multicenter study [4].
• Rheological experiments showed that the flow properties of PLGA/benzyl benzoate solutions were affected by a combination of degradation and gelation; the latter was also detected by an endotherm in DSC and by three-dimensional structure formation studies by rheology [8].
• The control group had the usual house dust mite control measures including the use of vinyl covers for mattresses and pillows while the treatment group had application of benzyl benzoate to mattresses and carpets in the bedroom and the most commonly used room, in addition to the above control measures [25].
• A significant higher mortality of eggs was evident after treatment with (i) disulfiram, (ii) benzyl benzoate, (iii) these two substances mixed, and (iv) Tenutex [20].
• Based on LD(50) values in fabric piece contact toxicity bioassays, the acaricidal activities of benzoic acid (4.80 microg cm(-2)) and paeonol (5.29 microg cm(-2)) were comparable to that of benzyl benzoate (4.46 microg cm(-2)) but more pronounced than those of DEET (30.03 microg cm(-2)) and dibutyl phthalate (25.23 microg cm(-2)) [26].

References