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High impact information on Melia

  • Toosendanin, a triterpenoid derivative extracted from Melia toosendan Sieb et Zucc, was demonstrated to be potentially useful in medical and scientific researches [1].
  • Antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from Melia azedarach L. fruits [2].
  • Efficacy of five nitrification inhibitors, i.e. neem (Azadirachta melia) cake, thiosulphate, coated calcium carbide, neem oil coated urea and dicyandiamide (DCD) and one urease inhibitor, hydroquinone, in mitigating N2O and CH4 emissions from fertilized soil was tested in rice-wheat system in the Indo-Gangetic plains [3].
  • In the continuous search for antifungal compounds from plants, the hydroxycoumarin scopoletin (1) was isolated from seed kernels of Melia azedarach L. from which three other compounds, vanillin (2), 4-hydroxy-3-methoxycinnamaldehyde (3), and (+/-) pinoresinol (4), have also been isolated [2].
  • A methanol extract of the ripe fruits of Melia azedarach collected in Curitiba, Parana, Brazil, afforded seven new ring C-seco limonoids (1-7) together with three known limonoids (8-10) [4].

Associations of Melia with chemical compounds

  • Evidence is presented for the structure of a new limonoid glycoside, 6-acetoxy-11 alpha-hydroxy-7-oxo-14 beta, 15 beta-epoxymeliacin-1,5-diene-3-O-alpha-L-rhamnopyranoside, which occurs together with salannin and meldenin in the seeds of Melia azedarach [5].
  • The roots of Melia azedarach yielded three new degraded limonoids: teracrylmelazolide A, melazolide A and teracrylmelazolide B, possessing a previously undescribed skeleton [6].
  • A study of the phagoinhibitor and anti-moulting activities of the Brazilian Melia azedarach, collected in the State of Rio de Janeiro, Brazil, allowed the isolation of four lignanes identified as pinoresinol (1), bis-epi-pinoresinol (2), the hemicetal (3) and the diacid (4) [7].
  • A glycopeptide isolated from the high plant Melia azedarach L [8].
  • Melain G, a cysteine protease from green fruits of the bead tree, Melia azedarach: a protease affected by specific amino acids at P3 position [9].

Gene context of Melia

  • In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two beta-carboline alkaloids, 4-methoxy-1-vinyl-beta-carboline (1) and 4,8-dimethoxy-l-vinyl-beta-carboline (2) have been isolated from the cortex of Melia azedarach var. japonica [10].


  1. Toosendanin, a triterpenoid derivative, acts as a novel agonist of L-type Ca2+ channels in neonatal rat ventricular cells. Li, M.F., Shi, Y.L. Eur. J. Pharmacol. (2004) [Pubmed]
  2. Antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from Melia azedarach L. fruits. Carpinella, M.C., Ferrayoli, C.G., Palacios, S.M. J. Agric. Food Chem. (2005) [Pubmed]
  3. Mitigating nitrous oxide and methane emissions from soil in rice-wheat system of the Indo-Gangetic plain with nitrification and urease inhibitors. Malla, G., Bhatia, A., Pathak, H., Prasad, S., Jain, N., Singh, J. Chemosphere (2005) [Pubmed]
  4. New ring C-seco limonoids from Brazilian Melia azedarach and their cytotoxic activity. Zhou, H., Hamazaki, A., Fontana, J.D., Takahashi, H., Esumi, T., Wandscheer, C.B., Tsujimoto, H., Fukuyama, Y. J. Nat. Prod. (2004) [Pubmed]
  5. Limonoids from the seeds of Melia azedarach. Srivastava, S.D. J. Nat. Prod. (1986) [Pubmed]
  6. Degraded limonoids from Melia azedarach and biogenetic implications. D'Ambrosio, M., Guerriero, A. Phytochemistry (2002) [Pubmed]
  7. Lignanes from the Brazilian Melia azedarach, and their activity in Rhodnius prolixus (Hemiptera, Reduviidae). Cabral, M.M., Garcia, E.S., Kelecom, A. Mem. Inst. Oswaldo Cruz (1995) [Pubmed]
  8. Meliacine, an antiviral compound from Melia azedarach L., inhibits interferon production. Andrei, G.M., Coulombie, F.C., Courreges, M.C., de Torres, R.A., Coto, C.E. J. Interferon Res. (1990) [Pubmed]
  9. Melain G, a cysteine protease from green fruits of the bead tree, Melia azedarach: a protease affected by specific amino acids at P3 position. Uchikoba, T., Yonezawa, H., Shimada, M., Kaneda, M. Biochim. Biophys. Acta (1999) [Pubmed]
  10. Inducible nitric oxide synthase inhibitors from Melia azedarach var. japonica. Kwon, H.C., Lee, B.G., Kim, S.H., Jung, C.M., Hong, S.Y., Han, J.W., Lee, H.W., Zee, O.P., Lee, K.R. Arch. Pharm. Res. (1999) [Pubmed]
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