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MeSH Review:

Mineralocorticoid Excess Syndrome, Apparent

Armanini, D. et al., Phillipov, G. et al., Palermo, M. et al., Edwards, C.R. et al., Soma, R. et al., et al.

Palermo, Delitala, Mantero, Stewart, Shackleton,

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Disease relevance of Mineralocorticoid Excess Syndrome, Apparent

This mechanism is related either to a mutation of the gene, which encodes 11HSD2 (apparent mineralocorticoid excess syndrome and some cases of low renin hypertension) or to an acquired reduction of the activity of the enzyme due to glycyrrhetinic acid, carbenoxolone, and grapefruit juice [1].

High impact information on Mineralocorticoid Excess Syndrome, Apparent

As an example, the tetrahydrocortisol plus 5 alpha-tetrahydrocortisol/tetrahydrocortisone ratio was about 0.04 compared to normal values of about 1.0 and apparent mineralocorticoid excess syndrome values of 5.0-50 [2].
This may be congenital as in the apparent mineralocorticoid excess syndrome or acquired secondary to liquorice-induced inhibition of 11 beta-OHSD [3].
Congenital deficiency of 11beta-hydroxysteroid dehydrogenase (apparent mineralocorticoid excess syndrome): diagnostic value of urinary free cortisol and cortisone [4].
The increased cortisol in the kidney could be the cause of the apparent mineralocorticoid excess syndrome induced by glycyrrhizin [5].

Chemical compound and disease context of Mineralocorticoid Excess Syndrome, Apparent

Does kidney transplantation normalise cortisol metabolism in apparent mineralocorticoid excess syndrome [6]?

References

Pseudohyperaldosteronism: pathogenetic mechanisms. Armanini, D., Calò, L., Semplicini, A. Critical reviews in clinical laboratory sciences. (2003) [Pubmed]
Apparent cortisone reductase deficiency: a unique form of hypercortisolism. Phillipov, G., Palermo, M., Shackleton, C.H. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
The cortisol-cortisone shuttle and the apparent specificity of glucocorticoid and mineralocorticoid receptors. Edwards, C.R., Stewart, P.M. J. Steroid Biochem. Mol. Biol. (1991) [Pubmed]
Congenital deficiency of 11beta-hydroxysteroid dehydrogenase (apparent mineralocorticoid excess syndrome): diagnostic value of urinary free cortisol and cortisone. Palermo, M., Delitala, G., Mantero, F., Stewart, P.M., Shackleton, C.H. J. Endocrinol. Invest. (2001) [Pubmed]
Effect of glycyrrhizin on cortisol metabolism in humans. Soma, R., Ikeda, M., Morise, T., Miyamori, I., Takeda, R. Endocrine regulations. (1994) [Pubmed]
Does kidney transplantation normalise cortisol metabolism in apparent mineralocorticoid excess syndrome? Palermo, M., Delitala, G., Sorba, G., Cossu, M., Satta, R., Tedde, R., Pala, A., Shackleton, C.H. J. Endocrinol. Invest. (2000) [Pubmed]

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