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Chemical Compound Review

C01058     (11S)-10,13-dimethyl- 2,3,4,5,6,7,8,9,11,12...

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Disease relevance of C01058


High impact information on C01058


Chemical compound and disease context of C01058


Biological context of C01058


Anatomical context of C01058


Associations of C01058 with other chemical compounds


Gene context of C01058


Analytical, diagnostic and therapeutic context of C01058


  1. Charting biologically relevant chemical space: a structural classification of natural products (SCONP). Koch, M.A., Schuffenhauer, A., Scheck, M., Wetzel, S., Casaulta, M., Odermatt, A., Ertl, P., Waldmann, H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Impaired 11beta-hydroxysteroid dehydrogenase contributes to renal sodium avidity in cirrhosis: Hypothesis or fact? Frey, F.J. Hepatology (2006) [Pubmed]
  3. Extracellular ATP determines 11beta-hydroxysteroid dehydrogenase type 2 activity via purinergic receptors. Kadereit, B., Fustier, P., Shojaati, K., Frey, B.M., Frey, F.J., Mohaupt, M.G. J. Am. Soc. Nephrol. (2005) [Pubmed]
  4. Increased apical targeting of renal epithelial sodium channel subunits and decreased expression of type 2 11beta-hydroxysteroid dehydrogenase in rats with CCl4-induced decompensated liver cirrhosis. Kim, S.W., Schou, U.K., Peters, C.D., de Seigneux, S., Kwon, T.H., Knepper, M.A., Jonassen, T.E., Frøkiaer, J., Nielsen, S. J. Am. Soc. Nephrol. (2005) [Pubmed]
  5. Reduced 11beta-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma. Murphy, V.E., Zakar, T., Smith, R., Giles, W.B., Gibson, P.G., Clifton, V.L. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  6. Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Draper, N., Walker, E.A., Bujalska, I.J., Tomlinson, J.W., Chalder, S.M., Arlt, W., Lavery, G.G., Bedendo, O., Ray, D.W., Laing, I., Malunowicz, E., White, P.C., Hewison, M., Mason, P.J., Connell, J.M., Shackleton, C.H., Stewart, P.M. Nat. Genet. (2003) [Pubmed]
  7. Steroid disorders in children: congenital adrenal hyperplasia and apparent mineralocorticoid excess. New, M.I., Wilson, R.C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Expression of 11beta-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells. Freeman, L., Hewison, M., Hughes, S.V., Evans, K.N., Hardie, D., Means, T.K., Chakraverty, R. Blood (2005) [Pubmed]
  9. Inhibition of 11beta-hydroxysteroid dehydrogenase by bile acids in rats with cirrhosis. Ackermann, D., Vogt, B., Escher, G., Dick, B., Reichen, J., Frey, B.M., Frey, F.J. Hepatology (1999) [Pubmed]
  10. 11Beta-hydroxysteroid dehydrogenase responsible for carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes. Maser, E. Cancer Res. (1998) [Pubmed]
  11. Impaired protein stability of 11beta-hydroxysteroid dehydrogenase type 2: a novel mechanism of apparent mineralocorticoid excess. Atanasov, A.G., Ignatova, I.D., Nashev, L.G., Dick, B., Ferrari, P., Frey, F.J., Odermatt, A. J. Am. Soc. Nephrol. (2007) [Pubmed]
  12. Failure of cortisone acetate treatment in congenital adrenal hyperplasia because of defective 11beta-hydroxysteroid dehydrogenase reductase activity. Nordenström, A., Marcus, C., Axelson, M., Wedell, A., Ritzén, E.M. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  13. Carbenoxolone damages endothelium and enhances vasoconstrictor action in aortic rings. Ullian, M.E., Hazen-Martin, D.J., Walsh, L.G., Davda, R.K., Egan, B.M. Hypertension (1996) [Pubmed]
  14. Cross talk between corticosteroids and alpha-adrenergic signalling augments cardiomyocyte hypertrophy: a possible role for SGK1. Lister, K., Autelitano, D.J., Jenkins, A., Hannan, R.D., Sheppard, K.E. Cardiovasc. Res. (2006) [Pubmed]
  15. Retinoic acid stimulates the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human choriocarcinoma JEG-3 cells. Tremblay, J., Hardy, D.B., Pereira, L.E., Yang, K. Biol. Reprod. (1999) [Pubmed]
  16. Molecular basis for hypertension in the "type II variant" of apparent mineralocorticoid excess. Li, A., Tedde, R., Krozowski, Z.S., Pala, A., Li, K.X., Shackleton, C.H., Mantero, F., Palermo, M., Stewart, P.M. Am. J. Hum. Genet. (1998) [Pubmed]
  17. Glucocorticoid-related genetic susceptibility for Alzheimer's disease. de Quervain, D.J., Poirier, R., Wollmer, M.A., Grimaldi, L.M., Tsolaki, M., Streffer, J.R., Hock, C., Nitsch, R.M., Mohajeri, M.H., Papassotiropoulos, A. Hum. Mol. Genet. (2004) [Pubmed]
  18. Purification and characterization of hamster liver microsomal 7alpha-hydroxycholesterol dehydrogenase. Similarity to type I 11beta-hydroxysteroid dehydrogenase. Song, W., Chen, J., Dean, W.L., Redinger, R.N., Prough, R.A. J. Biol. Chem. (1998) [Pubmed]
  19. In vivo footprinting of the human 11beta-hydroxysteroid dehydrogenase type 2 promoter: evidence for cell-specific regulation by Sp1 and Sp3. Nawrocki, A.R., Goldring, C.E., Kostadinova, R.M., Frey, F.J., Frey, B.M. J. Biol. Chem. (2002) [Pubmed]
  20. Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins. Haas, C.S., Creighton, C.J., Pi, X., Maine, I., Koch, A.E., Haines, G.K., Ling, S., Chinnaiyan, A.M., Holoshitz, J. Arthritis Rheum. (2006) [Pubmed]
  21. 11beta-hydroxysteroid dehydrogenase expression and activity in the human adrenal cortex. Mazzocchi, G., Rossi, G.P., Neri, G., Malendowicz, L.K., Albertin, G., Nussdorfer, G.G. FASEB J. (1998) [Pubmed]
  22. Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase. Frick, C., Atanasov, A.G., Arnold, P., Ozols, J., Odermatt, A. J. Biol. Chem. (2004) [Pubmed]
  23. Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta -hydroxysteroid dehydrogenase type 1 expression and activity. Berger, J., Tanen, M., Elbrecht, A., Hermanowski-Vosatka, A., Moller, D.E., Wright, S.D., Thieringer, R. J. Biol. Chem. (2001) [Pubmed]
  24. Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets. Davani, B., Khan, A., Hult, M., Mårtensson, E., Okret, S., Efendic, S., Jörnvall, H., Oppermann, U.C. J. Biol. Chem. (2000) [Pubmed]
  25. Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation. Cooper, M.S., Bujalska, I., Rabbitt, E., Walker, E.A., Bland, R., Sheppard, M.C., Hewison, M., Stewart, P.M. J. Bone Miner. Res. (2001) [Pubmed]
  26. The expression of 11 beta-hydroxysteroid dehydrogenase type I by lymphocytes provides a novel means for intracrine regulation of glucocorticoid activities. Zhang, T.Y., Ding, X., Daynes, R.A. J. Immunol. (2005) [Pubmed]
  27. 11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules. Bostanjoglo, M., Reeves, W.B., Reilly, R.F., Velázquez, H., Robertson, N., Litwack, G., Morsing, P., Dørup, J., Bachmann, S., Ellison, D.H., Bostonjoglo, M. J. Am. Soc. Nephrol. (1998) [Pubmed]
  28. Renal inactivation, mineralocorticoid generation, and 11beta-hydroxysteroid dehydrogenase inhibition ameliorate the antimineralocorticoid effect of progesterone in vivo. Quinkler, M., Meyer, B., Oelkers, W., Diederich, S. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  29. Localization of 11beta-hydroxysteroid dehydrogenase type 2 in rat tissues: in situ studies. Roland, B.L., Funder, J.W. Endocrinology (1996) [Pubmed]
  30. A genetic defect resulting in mild low-renin hypertension. Wilson, R.C., Dave-Sharma, S., Wei, J.Q., Obeyesekere, V.R., Li, K., Ferrari, P., Krozowski, Z.S., Shackleton, C.H., Bradlow, L., Wiens, T., New, M.I. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  31. A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11beta-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome. San Millán, J.L., Botella-Carretero, J.I., Alvarez-Blasco, F., Luque-Ramírez, M., Sancho, J., Moghetti, P., Escobar-Morreale, H.F. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  32. Angiotensin II regulates 11beta-hydroxysteroid dehydrogenase type 2 via AT2 receptors. Lanz, B., Kadereit, B., Ernst, S., Shojaati, K., Causevic, M., Frey, B.M., Frey, F.J., Mohaupt, M.G. Kidney Int. (2003) [Pubmed]
  33. Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring. Welberg, L.A., Seckl, J.R., Holmes, M.C. Eur. J. Neurosci. (2000) [Pubmed]
  34. Spatial and temporal patterns of expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 messenger RNA and glucocorticoid receptor protein in the murine placenta and uterus during late pregnancy. Thompson, A., Han, V.K., Yang, K. Biol. Reprod. (2002) [Pubmed]
  35. Reduced capacity for the reactivation of glucocorticoids in rheumatoid arthritis synovial cells: possible role of the sympathetic nervous system? Schmidt, M., Weidler, C., Naumann, H., Anders, S., Schölmerich, J., Straub, R.H. Arthritis Rheum. (2005) [Pubmed]
  36. Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. Paulmyer-Lacroix, O., Boullu, S., Oliver, C., Alessi, M.C., Grino, M. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  37. Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism. Draper, N., Echwald, S.M., Lavery, G.G., Walker, E.A., Fraser, R., Davies, E., Sørensen, T.I., Astrup, A., Adamski, J., Hewison, M., Connell, J.M., Pedersen, O., Stewart, P.M. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  38. Impact of restriction of placental and fetal growth on expression of 11beta-hydroxysteroid dehydrogenase type 1 and type 2 messenger ribonucleic acid in the liver, kidney, and adrenal of the sheep fetus. McMillen, I.C., Warnes, K.E., Adams, M.B., Robinson, J.S., Owens, J.A., Coulter, C.L. Endocrinology (2000) [Pubmed]
  39. Salt-sensitivity of blood pressure and decreased 11beta-hydroxysteroid dehydrogenase type 2 activity after renal transplantation. Schumacher, M., Frey, F.J., Montani, J.P., Dick, B., Frey, B.M., Ferrari, P. Transplantation (2002) [Pubmed]
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