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Chemical Compound Review

TETRAHYDROCORTISOL     2-hydroxy-1-[ (3R,5R,8R,9R,10S,11S,13S,14S. ..

Synonyms: Urocortisol, Tetrahydro F, SureCN93788, AG-K-22087, CHEMBL1908047, ...
 
 
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Disease relevance of TETRAHYDROCORTISOL

 

High impact information on TETRAHYDROCORTISOL

  • The urinary ratio of (tetrahydrocortisol + 5 alpha-tetrahydrocortisol)/tetrahydrocortisone, a measure of 11 beta-HSD2 activity, decreased from a median of 1.91 during biliary obstruction to 0.78 at 4 and 8 weeks after removal of the obstruction and normalization of plasma bile acid concentrations [6].
  • As in the adhesion studies, cortisol but not tetrahydrocortisol inhibited expression of ELAM-1 and ICAM-1 (both P < 0.005, n = 3 or 4) [7].
  • The urinary tetrahydrocortisol/5-alpha-tetrahydrocortisol ratios provided the highest index of discrimination between homozygotes (mean +/- SD, adults: 35.80 +/- 20.10; children: 15.48 +/- 7.91), heterozygotes (parents: 4.56 +/- 1.61; siblings and other relatives: 5.97 +/- 3.68), and normal subjects (1.07 +/- 0.36) [8].
  • Urinary tetrahydrocortisol and tetrahydrocortisone excretion increased 7- to 10-fold during ACTH administration [9].
  • CONCLUSIONS: Tetrahydrocortisol was not a glucocorticoid antagonist at the level of the classical glucocorticoid receptor and did not appear to antagonize systemically mediated glucocorticoid activity in the rat [4].
 

Chemical compound and disease context of TETRAHYDROCORTISOL

 

Biological context of TETRAHYDROCORTISOL

 

Anatomical context of TETRAHYDROCORTISOL

 

Associations of TETRAHYDROCORTISOL with other chemical compounds

 

Gene context of TETRAHYDROCORTISOL

 

Analytical, diagnostic and therapeutic context of TETRAHYDROCORTISOL

References

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  2. Reduced 11beta-hydroxysteroid dehydrogenase activity in patients with the nephrotic syndrome. Vogt, B., Dick, B., N'Gankam, V., Frey, F.J., Frey, B.M. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
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