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Gene Review

Hsd11b1  -  hydroxysteroid 11-beta dehydrogenase 1

Rattus norvegicus

Synonyms: 11-DH, 11-beta-HSD1, 11-beta-hydroxysteroid dehydrogenase 1, Corticosteroid 11-beta-dehydrogenase isozyme 1, Hsd11
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Disease relevance of Hsd11b1


High impact information on Hsd11b1


Chemical compound and disease context of Hsd11b1


Biological context of Hsd11b1


Anatomical context of Hsd11b1


Associations of Hsd11b1 with chemical compounds


Co-localisations of Hsd11b1

  • We have previously demonstrated (Bonvalet et al, J Clin Invest 86:832-837, 1990) that 11 beta-OHSD is colocalized with MR along the rabbit nephron [19].

Other interactions of Hsd11b1


Analytical, diagnostic and therapeutic context of Hsd11b1


  1. Early inflammatory responses in experimental cardiac hypertrophy and fibrosis: effects of 11 beta-hydroxysteroid dehydrogenase inactivation. Young, M.J., Moussa, L., Dilley, R., Funder, J.W. Endocrinology (2003) [Pubmed]
  2. Expression of 11 beta-hydroxysteroid dehydrogenase in rat osteoblastic cells: pre-receptor regulation of glucocorticoid responses in bone. Eyre, L.J., Rabbitt, E.H., Bland, R., Hughes, S.V., Cooper, M.S., Sheppard, M.C., Stewart, P.M., Hewison, M. J. Cell. Biochem. (2001) [Pubmed]
  3. Regulation of the 11 beta-hydroxysteroid dehydrogenase in the rat adrenal. Decrease enzymatic activity induced by ACTH. Morita, H., Cozza, E.N., Zhou, M.Y., Gomez-Sanchez, E.P., Romero, D.G., Gomez-Sanchez, C.E. Endocrine (1997) [Pubmed]
  4. Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats. Hermans, J.J., Steckel, B., Thijssen, H.H., Janssen, B.J., Netter, K.J., Maser, E. Steroids (1995) [Pubmed]
  5. The cortisol-cortisone shuttle and the apparent specificity of glucocorticoid and mineralocorticoid receptors. Edwards, C.R., Stewart, P.M. J. Steroid Biochem. Mol. Biol. (1991) [Pubmed]
  6. Down-regulation of hepatic and renal 11 beta-hydroxysteroid dehydrogenase in rats with liver cirrhosis. Escher, G., Nawrocki, A., Staub, T., Vishwanath, B.S., Frey, B.M., Reichen, J., Frey, F.J. Gastroenterology (1998) [Pubmed]
  7. Glucocorticoid exposure in utero: new model for adult hypertension. Benediktsson, R., Lindsay, R.S., Noble, J., Seckl, J.R., Edwards, C.R. Lancet (1993) [Pubmed]
  8. Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase. Agarwal, A.K., Monder, C., Eckstein, B., White, P.C. J. Biol. Chem. (1989) [Pubmed]
  9. Endogenous 11 beta-hydroxysteroid dehydrogenase inhibitors and their role in glucocorticoid Na+ retention and hypertension. Morris, D.J., Souness, G.W. Endocr. Res. (1996) [Pubmed]
  10. Inhibition of 11-beta-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring. Lindsay, R.S., Lindsay, R.M., Edwards, C.R., Seckl, J.R. Hypertension (1996) [Pubmed]
  11. Glucocorticoid metabolism in the newborn rat heart. Brem, A.S., Bina, R.B., Klinger, J.R., King, T., Werner, J.C. Proc. Soc. Exp. Biol. Med. (1995) [Pubmed]
  12. A novel 11 beta-hydroxysteroid dehydrogenase inhibitor contained in saiboku-to, a herbal remedy for steroid-dependent bronchial asthma. Homma, M., Oka, K., Niitsuma, T., Itoh, H. J. Pharm. Pharmacol. (1994) [Pubmed]
  13. Regulation of sodium-potassium adenosine triphosphate subunit gene expression by corticosteroids and 11 beta-hydroxysteroid dehydrogenase activity. Whorwood, C.B., Ricketts, M.L., Stewart, P.M. Endocrinology (1994) [Pubmed]
  14. LLC-PK1 cells model 11 beta-hydroxysteroid dehydrogenase type 2 regulation of glucocorticoid access to renal mineralocorticoid receptors. Leckie, C., Chapman, K.E., Edwards, C.R., Seckl, J.R. Endocrinology (1995) [Pubmed]
  15. The mineralocorticoid receptor discriminates aldosterone from glucocorticoids independently of the 11 beta-hydroxysteroid dehydrogenase. Lombes, M., Kenouch, S., Souque, A., Farman, N., Rafestin-Oblin, M.E. Endocrinology (1994) [Pubmed]
  16. Cortisol to cortisone: glucocorticoid to mineralocorticoid. Stewart, P.M., Mason, J.I. Steroids (1995) [Pubmed]
  17. Epithelial cell localization of type 2 11 beta-hydroxysteroid dehydrogenase in rat and human colon. Whorwood, C.B., Ricketts, M.L., Stewart, P.M. Endocrinology (1994) [Pubmed]
  18. 11 Beta-hydroxysteroid dehydrogenase type 2 in the postnatal and adult rat brain. Robson, A.C., Leckie, C.M., Seckl, J.R., Holmes, M.C. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  19. Multiple patterns of 11 beta-hydroxysteroid dehydrogenase catalytic activity along the mammalian nephron. Kenouch, S., Coutry, N., Farman, N., Bonvalet, J.P. Kidney Int. (1992) [Pubmed]
  20. 11 beta-Hydroxysteroid dehydrogenase activity and corticosteroid hormone action. Stewart, P.M., Whorwood, C.B. Steroids (1994) [Pubmed]
  21. Tissue specific effects of thyroid hormone on 11 beta-hydroxysteroid dehydrogenase gene expression. Whorwood, C.B., Sheppard, M.C., Stewart, P.M. J. Steroid Biochem. Mol. Biol. (1993) [Pubmed]
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