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MeSH Review:

Hyaenidae

Place, N.J. et al., Glickman, S.E. et al., Forger, N.G. et al., Drea, C.M. et al., Yalcinkaya, T.M. et al., et al.

Forger, Frank, Breedlove, Glickman, Dloniak, French, Place, Weldele, Glickman, Holekamp, Place, Holekamp, Sisk, Weldele, Coscia, Drea, Glickman, East, Moestl, Benetka, Pitra, Höner, Wachter, Hofer, Drea, Vignieri, Cunningham, Glickman, Koepfli, Jenks, Eizirik, Zahirpour, Van Valkenburgh, Wayne, Muller, Wrangham,

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Disease relevance of Hyaenidae

Androstenedione production by residual ovarian stromal cells during reproductive life accounts for the epigenetic transmission of virilization in female spotted hyenas [1].
Sera from 38 free-ranging spotted hyenas (Crocuta crocuta) in the Serengeti ecosystem, Tanzania, were screened for exposure to coronavirus of antigenic group 1 [2].

High impact information on Hyaenidae

Results of studies of circulating testosterone levels in wild spotted hyenas do not account for the "male-like" characteristics of the female [3].
We have analyzed partial DNA sequences of the mitochondrial cytochrome b gene from extant striped, brown, and spotted hyenas as well as from Pleistocene cave hyenas [4].
Genital masculinization in female spotted hyenas has been widely explained as an incidental consequence of high androgen levels [5].
Effects of prenatal treatment with antiandrogens on luteinizing hormone secretion and sex steroid concentrations in adult spotted hyenas, Crocuta crocuta [6].
To determine whether LH secretion in spotted hyenas is affected by prenatal androgens, we treated pregnant hyenas with antiandrogens (flutamide and finasteride) [6].

Biological context of Hyaenidae

[Hyaenidae; phylogeny; cytochrome b; nuclear gene segments; Proteles; Crocuta; Hyaena; Parahyaena.] [7].

Anatomical context of Hyaenidae

Female spotted hyenas are known for their male-like genitalia, high levels of aggression, and dominance over males, characteristics which are attributed to exposure to elevated levels of testosterone in utero [8].

Associations of Hyaenidae with chemical compounds

Androstenedione may organize or activate sex-reversed traits in female spotted hyenas [3].
When hyenas wore carrion, they gained positive social attention (increased investigation and allogrooming) from pen mates, but when they wore camphor, the normal social greeting ceremony was curtailed [9].

Gene context of Hyaenidae

LHRH challenge in three male and two female hyenas in captivity caused an increase in fecal androgens one to three days after LHRH injection [10].

References

A mechanism for virilization of female spotted hyenas in utero. Yalcinkaya, T.M., Siiteri, P.K., Vigne, J.L., Licht, P., Pavgi, S., Frank, L.G., Glickman, S.E. Science (1993) [Pubmed]
Coronavirus infection of spotted hyenas in the Serengeti ecosystem. East, M.L., Moestl, K., Benetka, V., Pitra, C., Höner, O.P., Wachter, B., Hofer, H. Vet. Microbiol. (2004) [Pubmed]
Androstenedione may organize or activate sex-reversed traits in female spotted hyenas. Glickman, S.E., Frank, L.G., Davidson, J.M., Smith, E.R., Siiteri, P.K. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
The population history of extant and extinct hyenas. Rohland, N., Pollack, J.L., Nagel, D., Beauval, C., Airvaux, J., Pääbo, S., Hofreiter, M. Mol. Biol. Evol. (2005) [Pubmed]
Sexual mimicry in hyenas. Muller, M.N., Wrangham, R. The Quarterly review of biology. (2002) [Pubmed]
Effects of prenatal treatment with antiandrogens on luteinizing hormone secretion and sex steroid concentrations in adult spotted hyenas, Crocuta crocuta. Place, N.J., Holekamp, K.E., Sisk, C.L., Weldele, M.L., Coscia, E.M., Drea, C.M., Glickman, S.E. Biol. Reprod. (2002) [Pubmed]
Molecular systematics of the Hyaenidae: relationships of a relictual lineage resolved by a molecular supermatrix. Koepfli, K.P., Jenks, S.M., Eizirik, E., Zahirpour, T., Van Valkenburgh, B., Wayne, R.K. Mol. Phylogenet. Evol. (2006) [Pubmed]
Sexual dimorphism of perineal muscles and motoneurons in spotted hyenas. Forger, N.G., Frank, L.G., Breedlove, S.M., Glickman, S.E. J. Comp. Neurol. (1996) [Pubmed]
Responses to olfactory stimuli in spotted hyenas (Crocuta crocuta): I. Investigation of environmental odors and the function of rolling. Drea, C.M., Vignieri, S.N., Cunningham, S.B., Glickman, S.E. Journal of comparative psychology (Washington, D.C. : 1983) (2002) [Pubmed]
Non-invasive monitoring of fecal androgens in spotted hyenas (Crocuta crocuta). Dloniak, S.M., French, J.A., Place, N.J., Weldele, M.L., Glickman, S.E., Holekamp, K.E. Gen. Comp. Endocrinol. (2004) [Pubmed]

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