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MeSH Review:

Pituitary ACTH Hypersecretion

Kageyama, K. et al., Gsponer, J. et al., Houwen, R.H. et al., Miller, W.L. et al., Catrina, S.B. et al., et al.

Kageyama, Nigawara, Kamata, Terui, Anzai, Sakihara, Suda, Simmons, Alden, Thorner, Laws, Chen, Amar, Choi, Singer, Couldwell, Weiss,

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Disease relevance of Pituitary ACTH Hypersecretion

Selective venous sampling for ACTH in Cushing's syndrome: differentiation between Cushing disease and the ectopic ACTH syndrome [1].
Synthesis and glycosylation of POMC were studied in a pituitary adenoma causing Cushing disease and in adjacent tissue by incubating intact tissue explants in medium containing [35S]methionine or [3H]glucosamine [2].
Pituitary adenoma with growth hormone (GH) and corticotropin (ACTH) production causing apparent acromegaly and Cushing disease is extremely rare [3].

High impact information on Pituitary ACTH Hypersecretion

In Cushing disease, single evening plasma cortisol was as good as the overnight dexamethasone suppression test for screening, and a combined dexamethasoneovine corticotropin-releasing hormone (oCRH) test was as accurate as the long dexamethasone suppression test to confirm the diagnosis [4].
Transsphenoidal microsurgical treatment of Cushing disease: postoperative assessment of surgical efficacy by application of an overnight low-dose dexamethasone suppression test [5].
Serum cortisol response to transsphenoidal surgery for Cushing disease [6].
Gadolinium diethylenetriamine pentaacetic acid (DTPA) enhanced magnetic resonance imaging was performed in eight patients with Cushing disease and surgically proven pituitary microadenomas [7].
The treatment of choice of pituitary-dependent Cushing disease is transsphenoidal resection of the microadenoma while in primary adrenocortical nodular dysplasia bilateral adrenalectomy with subsequent steroid replacement is recommended [8].

Chemical compound and disease context of Pituitary ACTH Hypersecretion

Their use for treatment of Cushing Disease (CD) has been suggested but the clinical experience with the two PPAR-gamma agonists commercially available (rosiglitazone and pioglitazone) was not impressive [9].

Anatomical context of Pituitary ACTH Hypersecretion

Bilateral simultaneous cavernous sinus sampling using corticotropin-releasing hormone in the evaluation of Cushing disease [10].

Gene context of Pituitary ACTH Hypersecretion

The elevated ACTH and cortisol levels should therefore be investigated by CRH and dexamethasone suppression tests for the coexistence of Cushing disease to exclude the possibility of underlying ACTH-producing tumors [3].

References

Selective venous sampling for ACTH in Cushing's syndrome: differentiation between Cushing disease and the ectopic ACTH syndrome. Findling, J.W., Aron, D.C., Tyrrell, J.B., Shinsako, J.H., Fitzgerald, P.A., Norman, D., Wilson, C.B., Forsham, P.H. Ann. Intern. Med. (1981) [Pubmed]
Synthesis and glycosylation of proopiomelanocortin by a Cushing tumor. Miller, W.L., Johnson, L.K. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
A multihormonal pituitary adenoma with growth hormone and adrenocorticotropic hormone production, causing acromegaly and Cushing disease. Kageyama, K., Nigawara, T., Kamata, Y., Terui, K., Anzai, J., Sakihara, S., Suda, T. Am. J. Med. Sci. (2002) [Pubmed]
Diagnosis, treatment, and outcome of pituitary tumors and other abnormal intrasellar masses. Retrospective analysis of 353 patients. Gsponer, J., De Tribolet, N., Déruaz, J.P., Janzer, R., Uské, A., Mirimanoff, R.O., Reymond, M.J., Rey, F., Temler, E., Gaillard, R.C., Gomez, F. Medicine (Baltimore) (1999) [Pubmed]
Transsphenoidal microsurgical treatment of Cushing disease: postoperative assessment of surgical efficacy by application of an overnight low-dose dexamethasone suppression test. Chen, J.C., Amar, A.P., Choi, S., Singer, P., Couldwell, W.T., Weiss, M.H. J. Neurosurg. (2003) [Pubmed]
Serum cortisol response to transsphenoidal surgery for Cushing disease. Simmons, N.E., Alden, T.D., Thorner, M.O., Laws, E.R. J. Neurosurg. (2001) [Pubmed]
Gadolinium DTPA enhanced MR imaging of ACTH-secreting microadenomas of the pituitary gland. Doppman, J.L., Frank, J.A., Dwyer, A.J., Oldfield, E.H., Miller, D.L., Nieman, L.K., Chrousos, G.P., Cutler, G.B., Loriaux, D.L. Journal of computer assisted tomography. (1988) [Pubmed]
Pituitary-dependent Cushing disease and primary adrenocortical nodular dysplasia in childhood. Presentation of 4 cases. Houwen, R.H., Drop, S.L., Hazebroek, F.W., ten Kate, F.W. Eur. J. Pediatr. (1983) [Pubmed]
Effect of rosiglitazone on early-morning plasma cortisol levels. Catrina, S.B., Virtanen, K., Hällsten, K., Lönnqvist, F., Nuutila, P., Brismar, K. Neuro Endocrinol. Lett. (2005) [Pubmed]
Bilateral simultaneous cavernous sinus sampling using corticotropin-releasing hormone in the evaluation of Cushing disease. Oliverio, P.J., Monsein, L.H., Wand, G.S., Debrun, G.M. AJNR. American journal of neuroradiology. (1996) [Pubmed]

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