The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Bentylol     2-diethylaminoethyl 1-cyclohexylcyclohexan...

Synonyms: Dicymine, Formulex, Mamiesan, Bentomine, Merbentyl, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Bentylol


Psychiatry related information on Bentylol

  • Several members of these classes possess analgesic properties which are comparable to that of morphine and at the same time are able to reverse dicyclomine-induced amnesia [6].
  • RESULTS: Compared with placebo, neither dose of darifenacin affected cognitive function, whereas dicyclomine impaired performance on five of the 12 variables 2 h after dosing; simple reaction time (P = 0.009), speed of numeric (P = 0.012) and spatial (P = 0.048) working memory, and speed (P = 0.04) and sensitivity (P = 0.03) of picture recognition [7].
  • The increase in the pain threshold produced by SM 32 was prevented by dicyclomine, pirenzepine and hemicholinium-3 but not by naloxone and CGP 35348 [8].

High impact information on Bentylol

  • We further demonstrate that administration of dicyclomine, an M1 antagonist, exacerbates the Abeta and tau pathologies [9].
  • Evidence from controlled trials has demonstrated the safety and efficacy of the following drugs for the treatment of varying degrees of NVP: doxylamine/pyridoxine+/-dicycloverine (dicyclomine), antihistamine H1 receptor antagonists, and phenothiazines (as a group) [10].
  • Dicyclomine discriminates between M1- and M2-muscarinic receptors in the guinea-pig ileum [11].
  • Other agents used in clinical urology that are believed to act at least in part by antimuscarinic activity include oxybutynin, imipramine and dicyclomine, These studies were designed to determine the relative potency of a variety of agents to compete directly for muscarinic cholinergic receptors isolated from the canine and rabbit urinary bladder [12].
  • Both doses of dicyclomine significantly reduced resting heart rate, but unlike scopolamine, significantly enhanced the cardiovascular response to fluid percussion injury [4].

Chemical compound and disease context of Bentylol


Biological context of Bentylol

  • Whether this observation might be caused by heterogeneous binding-sites for oxybutynine and dicyclomine or some other phenomenon is under further investigation [18].
  • The effect of repeated treatment with indomethacin (IND) on the disposition and intestinal absorption of the drug and microsomal drug-metabolizing enzyme activities were studied in comparison with coadministration of the drug and magnesium silicate or dicyclomine in male Wistar rats [19].

Anatomical context of Bentylol

  • Pirenzepine and dicyclomine, two other selective muscarinic antagonists, showed a similar behaviour in all but the sublingual gland, where their binding profile indicated the presence of a heterogeneous receptor population (nH = 0.74 and 0.84, respectively) [20].
  • In both species dicyclomine inhibitory effects were most marked in the bladder body, moderate in the bladder base, and minimal in the proximal urethra [21].
  • In contrast to traditional muscarinic antagonists, four drugs - namely, oxybutynine, dicyclomine, benzhexol and pirenzepine - bound with a significantly higher affinity in the parotid gland than in the urinary bladder and ileum [22].
  • It is concluded that dicyclomine not only acts as an anticholinergic agent but also impairs excitation-contraction coupling and release of transmitter from autonomic nerves [23].
  • BACKGROUND: It has been demonstrated that oral administration of dicyclomine significantly reduces the noise associated with the movement of the gastrointestinal tract in abdominal magnetic resonance (MR) images [24].

Associations of Bentylol with other chemical compounds


Gene context of Bentylol

  • When compared with the control group, IV butylscopolamine (p < 0.05) and oral dicyclomine (p < 0.05) significantly reduced gastrointestinal noise, whereas glucagon did not [26].
  • When administered to Swiss white mice at doses of 30 and 60 microg/mouse, dicyclomine protected the animals challenged with 50 MLD of Salmonella typhimurium NCTC 74 [27].
  • Although safely used for years for infantile colic, recently, the administration of dicyclomine has been related to acute episodes of apnea, seizures, and coma [28].

Analytical, diagnostic and therapeutic context of Bentylol


  1. Dicyclomine for idiopathic dyspepsia. Stephens, C.J., Lever, L., Hoare, A.M. Lancet (1988) [Pubmed]
  2. Dicyclomine in infantile colic. Weissbluth, M. J. Pediatr. (1984) [Pubmed]
  3. Dicyclomine, an M1 muscarinic antagonist, reduces infarct volume in a rat subdural hematoma model. Jiang, Z.W., Gong, Q.Z., Di, X., Zhu, J., Lyeth, B.G. Brain Res. (2000) [Pubmed]
  4. The effect of M1 muscarinic blockade on behavior and physiological responses following traumatic brain injury in the rat. Robinson, S.E., Foxx, S.D., Posner, M.G., Martin, R.M., Davis, T.R., Guo, H.Z., Enters, E.K. Brain Res. (1990) [Pubmed]
  5. Treatment of urge incontinence in Veterans Affairs medical centers. Malone, D.C., Okano, G.J. Clinical therapeutics. (1999) [Pubmed]
  6. Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 2. 2-Phenoxy-, 2-(phenylthio)-, and 2-(phenylamino)alkanoic acid esters. Gualtieri, F., Bottalico, C., Calandrella, A., Dei, S., Giovannoni, M.P., Mealli, S., Romanelli, M.N., Scapecchi, S., Teodori, E., Galeotti, N. J. Med. Chem. (1994) [Pubmed]
  7. Pharmacodynamic effects of darifenacin, a muscarinic M selective receptor antagonist for the treatment of overactive bladder, in healthy volunteers. Kay, G.G., Wesnes, K.A. BJU international. (2005) [Pubmed]
  8. Antinociception induced by SM 32 depends on a central cholinergic mechanism. Ghelardini, C., Galeotti, N., Gualtieri, F., Novella Romanelli, M., Bartolini, A. Pharmacol. Res. (1997) [Pubmed]
  9. M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Caccamo, A., Oddo, S., Billings, L.M., Green, K.N., Martinez-Coria, H., Fisher, A., LaFerla, F.M. Neuron (2006) [Pubmed]
  10. A risk-benefit assessment of pharmacological and nonpharmacological treatments for nausea and vomiting of pregnancy. Mazzotta, P., Magee, L.A. Drugs (2000) [Pubmed]
  11. Dicyclomine discriminates between M1- and M2-muscarinic receptors in the guinea-pig ileum. Kilbinger, H., Stein, A. Br. J. Pharmacol. (1988) [Pubmed]
  12. Direct measurement of the anticholinergic activity of a series of pharmacological compounds on the canine and rabbit urinary bladder. Levin, R.M., Wein, A.J. J. Urol. (1982) [Pubmed]
  13. Treatment of infantile colic with dicyclomine hydrochloride. Weissbluth, M., Christoffel, K.K., Davis, A.T. J. Pediatr. (1984) [Pubmed]
  14. Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score. Shapiro, S., Heinonen, O.P., Siskind, V., Kaufman, D.W., Monson, R.R., Slone, D. Am. J. Obstet. Gynecol. (1977) [Pubmed]
  15. Evaluation of the efficacy of dicyclomine hydrochloride ('Merbentyl') syrup in the treatment of infant colic. Grunseit, F. Current medical research and opinion. (1977) [Pubmed]
  16. Role of 5-HT1A receptors in a mouse passive avoidance paradigm. Galeotti, N., Ghelardini, C., Bartolini, A. Jpn. J. Pharmacol. (2000) [Pubmed]
  17. Antiamnesic activity of metoclopramide, cisapride and SR-17 in the mouse passive avoidance test. Galeotti, N., Ghelardini, C., Teodori, E., Gualtieri, F., Bartolini, A. Pharmacol. Res. (1997) [Pubmed]
  18. Muscarinic receptor binding in the parotid gland. Different affinities of some anticholinergic drugs between the parotid gland and ileum. Nilvebrant, L., Sparf, B. Scand. J. Gastroenterol. Suppl. (1982) [Pubmed]
  19. Disposition, intestinal absorption and drug metabolizing enzyme activities after multiple doses of indomethacin in rat and effect of antacid and dicyclomine on the parameters. Ogiso, T., Iwaki, M., Tamaki, E. J. Pharmacobio-dyn. (1982) [Pubmed]
  20. Characterization of muscarinic receptors in salivary and lacrimal glands of the rat. Martos, F., Monferini, E., Giraldo, E., De Paoli, A.M., Hammer, R. Eur. J. Pharmacol. (1987) [Pubmed]
  21. In vitro study of antispasmodic effects of dicyclomine hydrochloride on vesicourethral smooth muscle of guinea pig and rabbit. Khanna, O.P., DiGregorio, G.J., Barbieri, E.J., McMichael, R., Ruch, E. Urology (1979) [Pubmed]
  22. Differences between binding affinities of some antimuscarinic drugs in the parotid gland and those in the urinary bladder and ileum. Nilvebrant, L., Sparf, B. Acta pharmacologica et toxicologica. (1983) [Pubmed]
  23. The mechanism of action of dicyclomine hydrochloride on rabbit detrusor muscle and vas deferens. Johns, A., Tasker, J.J., Johnson, C.E., Theman, M.A., Paton, D.M. Archives internationales de pharmacodynamie et de thérapie. (1976) [Pubmed]
  24. Dose effect of dicyclomine on the reduction of peristaltic artifacts on MRI of the abdomen. Martí-Bonmatí, L., Dosdá, R., Ronchera-Oms, C.L., Casillas, C. Abdominal imaging. (1999) [Pubmed]
  25. Nuclear magnetic resonance spectroscopic determination of dicyclomine hydrochloride in tablet, capsule, and injection dosage forms. Hanna, G.M. Journal - Association of Official Analytical Chemists. (1984) [Pubmed]
  26. Reduction of peristaltic artifacts on magnetic resonance imaging of the abdomen: a comparative evaluation of three drugs. Martí-Bonmatí, L., Graells, M., Ronchera-Oms, C.L. Abdominal imaging. (1996) [Pubmed]
  27. Antibacterial potential of an antispasmodic drug dicyclomine hydrochloride. Karak, P., Kumar, K.A., Mazumdar, K., Mookerjee, M., Dastidar, S.G. Indian J. Med. Res. (2003) [Pubmed]
  28. Dicyclomine in the sudden infant death syndrome (SIDS)--a cause of death or an incidental finding? Randall, B., Gerry, G., Rance, F. J. Forensic Sci. (1986) [Pubmed]
  29. Determination of nanogram amounts of dicyclomine with gas chromatography and nitrogen-selective detection. Beretta, E., Vanazzi, G. J. Chromatogr. (1984) [Pubmed]
  30. Treatment of the irritable bowel syndrome with Bentyl (dicyclomine hydrochloride). Page, J.G., Dirnberger, G.M. J. Clin. Gastroenterol. (1981) [Pubmed]
WikiGenes - Universities