Disease relevance of Bentylol

• Dicyclomine for idiopathic dyspepsia [1].
• Dicyclomine in infantile colic [2].
• Dicyclomine, an M1 muscarinic antagonist, reduces infarct volume in a rat subdural hematoma model [3].
• Dicyclomine (1 mg/kg or 10 mg/kg), scopolamine (1 mg/kg), or saline was administered intraperitoneally to rats 15 min prior to moderate fluid percussion brain injury [4].
• The results of this study suggest that oxybutynin, dicyclomine, and imipramine are the agents most commonly used to treat urinary incontinence within Veterans Affairs medical centers [5].

Psychiatry related information on Bentylol

• Several members of these classes possess analgesic properties which are comparable to that of morphine and at the same time are able to reverse dicyclomine-induced amnesia [6].
• RESULTS: Compared with placebo, neither dose of darifenacin affected cognitive function, whereas dicyclomine impaired performance on five of the 12 variables 2 h after dosing; simple reaction time (P = 0.009), speed of numeric (P = 0.012) and spatial (P = 0.048) working memory, and speed (P = 0.04) and sensitivity (P = 0.03) of picture recognition [7].
• The increase in the pain threshold produced by SM 32 was prevented by dicyclomine, pirenzepine and hemicholinium-3 but not by naloxone and CGP 35348 [8].

High impact information on Bentylol

• We further demonstrate that administration of dicyclomine, an M1 antagonist, exacerbates the Abeta and tau pathologies [9].
• Evidence from controlled trials has demonstrated the safety and efficacy of the following drugs for the treatment of varying degrees of NVP: doxylamine/pyridoxine+/-dicycloverine (dicyclomine), antihistamine H1 receptor antagonists, and phenothiazines (as a group) [10].
• Dicyclomine discriminates between M1- and M2-muscarinic receptors in the guinea-pig ileum [11].
• Other agents used in clinical urology that are believed to act at least in part by antimuscarinic activity include oxybutynin, imipramine and dicyclomine, These studies were designed to determine the relative potency of a variety of agents to compete directly for muscarinic cholinergic receptors isolated from the canine and rabbit urinary bladder [12].
• Both doses of dicyclomine significantly reduced resting heart rate, but unlike scopolamine, significantly enhanced the cardiovascular response to fluid percussion injury [4].

Chemical compound and disease context of Bentylol

• Treatment of infantile colic with dicyclomine hydrochloride [13].
• Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score [14].
• Evaluation of the efficacy of dicyclomine hydrochloride ('Merbentyl') syrup in the treatment of infant colic [15].
• Pretreatment with the 5-HT1A-receptor agonists 8-OH-DPAT ((+/-)-8-hydroxy-dipropylaminotetralin) and 5-CT (5-carboxamidotryptamine) dose-dependently prevented the amnesia induced by 5-HT1A antagonists, scopolamine, dicyclomine and exposure to an hypoxic environment [16].
• Metoclopramide (1-5 mg kg-1 i.p.), cisapride (0.5-2 mg kg-1 i.p.) and SR-17 (1-10 mg kg-1 i.p.), administered 20 min before the training session, prevented dicyclomine-induced amnesia [17].

Biological context of Bentylol

• Whether this observation might be caused by heterogeneous binding-sites for oxybutynine and dicyclomine or some other phenomenon is under further investigation [18].
• The effect of repeated treatment with indomethacin (IND) on the disposition and intestinal absorption of the drug and microsomal drug-metabolizing enzyme activities were studied in comparison with coadministration of the drug and magnesium silicate or dicyclomine in male Wistar rats [19].

Anatomical context of Bentylol

• Pirenzepine and dicyclomine, two other selective muscarinic antagonists, showed a similar behaviour in all but the sublingual gland, where their binding profile indicated the presence of a heterogeneous receptor population (nH = 0.74 and 0.84, respectively) [20].
• In both species dicyclomine inhibitory effects were most marked in the bladder body, moderate in the bladder base, and minimal in the proximal urethra [21].
• In contrast to traditional muscarinic antagonists, four drugs - namely, oxybutynine, dicyclomine, benzhexol and pirenzepine - bound with a significantly higher affinity in the parotid gland than in the urinary bladder and ileum [22].
• It is concluded that dicyclomine not only acts as an anticholinergic agent but also impairs excitation-contraction coupling and release of transmitter from autonomic nerves [23].
• BACKGROUND: It has been demonstrated that oral administration of dicyclomine significantly reduces the noise associated with the movement of the gastrointestinal tract in abdominal magnetic resonance (MR) images [24].

Associations of Bentylol with other chemical compounds

• Nuclear magnetic resonance spectroscopic determination of dicyclomine hydrochloride in tablet, capsule, and injection dosage forms [25].

Gene context of Bentylol

• When compared with the control group, IV butylscopolamine (p < 0.05) and oral dicyclomine (p < 0.05) significantly reduced gastrointestinal noise, whereas glucagon did not [26].
• When administered to Swiss white mice at doses of 30 and 60 microg/mouse, dicyclomine protected the animals challenged with 50 MLD of Salmonella typhimurium NCTC 74 [27].
• Although safely used for years for infantile colic, recently, the administration of dicyclomine has been related to acute episodes of apnea, seizures, and coma [28].

Analytical, diagnostic and therapeutic context of Bentylol

• Determination of nanogram amounts of dicyclomine with gas chromatography and nitrogen-selective detection [29].
• In a prospective cohort study of 20, 282 gravidas and their offspring, congenital malformation rates were similar in the children of over 1,000 women exposed and those not exposed to two components of Bendectin (doxylamine succinate and dicyclomine hydrochloride) during the first four lunar months of pregnancy [14].
• These cognitive changes were accompanied by slowing of the EEG for dicyclomine [7].
• During the 2-week double-blind study, the effects of dicyclomine hydrochloride compared to placebo were assesed by: 1) physicians' global evaluation of treatment, 2) patients' self-evaluation of treatment, and 3) patients' evaluation of duration of abdominal pain [30].
• Patients were randomly distributed into three groups of 16 patients each: (a) no-drug control group, (b) 20 mg of dicyclomine chlorhydrate, and (c) 80 mg of dicyclomine chlorhydrate [24].

References