Disease relevance of Acanthoma

• Styrene oxide produced a high incidence of tumors in the forestomach (papillomas, acanthomas, and in situ and invasive squamous cell carcinomas) [1].

High impact information on Acanthoma

• Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency [2].
• Immunohistochemical characterization of keratin expression in clear cell acanthoma [3].
• In this study, seven cases of clear cell acanthoma were analysed by immunohistochemical techniques, using various monoclonal antikeratin antibodies, and antibodies against filaggrin, involucrin and epithelial membrane antigen [3].
• 8. The percentage of cells with positive nuclear staining for PCNA/cyclin was < 20% in all cases of large-cell acanthoma [4].
• Sections from paraffin-embedded tissues identified histologically as epidermolytic acanthoma were examined for the presence of human papillomavirus (HPV) types 6, 11, 16, 18, and 33 using the polymerase chain reaction followed by dot-blot analysis with specific radiolabelled detecting probes [5].

Chemical compound and disease context of Acanthoma

• Etretinate therapy of solar-related kerato acanthoma [6].
• After surgical therapy a circumscribed relapse of viral acanthoma developed, which responded favourably to a combined antiviral and antiproliferative therapy with acitretin perorally and interferon, first subcutaneously, later intralesionally for 3 months [7].

Analytical, diagnostic and therapeutic context of Acanthoma

• We studied seven cases of large-cell acanthoma by image analysis cytometry for DNA content and by immunohistochemistry, using antibodies to proliferating cell nuclear antigen (PCNA)/cyclin [4].

References