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Gene Review

EMP1  -  epithelial membrane protein 1

Homo sapiens

Synonyms: B4B, CL-20, EMP-1, Epithelial membrane protein 1, Protein B4B, ...
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Disease relevance of EMP1


High impact information on EMP1


Chemical compound and disease context of EMP1


Biological context of EMP1

  • EPO-mimetic peptides, such as EMP1, also bind and activate the receptor by dimerization [14].
  • The ability of this peptide to effectively serve as a mimetic capable of the induction of EPO-responsive cell proliferation appears to reside within a single residue, equivalent to position Tyr4 of EMP1, when present in a sequence that includes the cyclic core peptide structure [15].
  • cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family [16].
  • The hCL-20 gene contains five exons about 0.2, 0.12, 0.1, 0.14, and 2.2 kb and four introns about 15, 1.9, 0.1, and 0.7 kb [16].
  • Like PMP22, CL-20 is likely to play important roles in the regulation of cell proliferation, differentiation, and cell death [16].

Anatomical context of EMP1

  • One EPO mimetic peptide sequence, EMP1, was targeted and more than 25 derivatives of this sequence were evaluated for their ability to compete with [125I]EPO for receptor binding and for their ability to support the proliferation of two EPO-responsive cell lines [15].
  • Retinoic acid, which inhibits squamous differentiation, represses CL-20 expression in normal human bronchial epithelial cells [16].
  • CL-20 is a novel gene encoding a protein that is structurally related to but distinct from the peripheral myelin protein PMP22 [16].
  • The expression patterns of the TMP and PMP22 genes in NIH-3T3 fibroblasts were compared at different proliferation states [1].
  • B4B, a novel growth-arrest gene, is expressed by a subset of progenitor/pre-B lymphocytes negative for cytoplasmic mu-chain [17].

Associations of EMP1 with chemical compounds

  • A gene isolated in this screen, named TMP (tumor-associated membrane protein), codes for a putative glycoprotein with four transmembrane domains [1].
  • Epithelial membrane protein-1 is a biomarker of gefitinib resistance [2].
  • Effect of barrier-breaking agents on intracellular pH and epithelial membrane resistances: studies in isolated Necturus antral mucosa exposed to luminal acid [18].
  • In these studies, we define a monoclonal antibody, C5/D5, raised against epithelial membrane preparations, which markedly inhibits PMN migration across polarized monolayers of the human intestinal epithelial cell line T84 in a bidirectional fashion [19].
  • Finally the orientation of the galactose toward the gp41 lectin site appears to be controlled by the lipid microenvironment of the epithelial membrane [20].

Physical interactions of EMP1

  • Thus, positive staining with epithelial membrane antigen and the identification of a large number of rough endoplasmic reticulum-mitochondrial complexes are suggestive of metastatic chordoma [21].

Co-localisations of EMP1


Regulatory relationships of EMP1


Other interactions of EMP1

  • Identification of a 13 amino acid peptide mimetic of erythropoietin and description of amino acids critical for the mimetic activity of EMP1 [15].
  • A member of this peptide family, EMP1 (EPO mimetic peptide 1), was used to solve the crystal structure of the soluble EPO receptor in complex with this peptide [24].
  • In one strain of parasite there was a significant difference in relative mobility of the 125I-surface-labeled Pf EMP 1 and the biosynthetically labeled Pf EMP 2, further distinguishing these proteins [25].
  • As markers BCEI and D21S154 have previously been localized to 21q22.3 by physical methods, our findings place the EMP1 gene locus (for progressive myoclonus epilepsy of the Unverricht-Lundborg type) in chromosome 21 band q22 [26].
  • Immunohistochemical studies were performed with the avidin-biotin-peroxidase complex method using monoclonal antibodies to p53(DO7), CD99(O13), epithelial membrane antigen, CD5(NCL-CD5-4C7), vimentin (V9), and cytokeratins 7, 8, 18, and 19 [27].

Analytical, diagnostic and therapeutic context of EMP1


  1. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. Ben-Porath, I., Benvenisty, N. Gene (1996) [Pubmed]
  2. Epithelial membrane protein-1 is a biomarker of gefitinib resistance. Jain, A., Tindell, C.A., Laux, I., Hunter, J.B., Curran, J., Galkin, A., Afar, D.E., Aronson, N., Shak, S., Natale, R.B., Agus, D.B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Analysis of gene expression profile induced by EMP-1 in esophageal cancer cells using cDNA Microarray. Wang, H.T., Kong, J.P., Ding, F., Wang, X.Q., Wang, M.R., Liu, L.X., Wu, M., Liu, Z.H. World J. Gastroenterol. (2003) [Pubmed]
  4. Immunohistochemistry of capillary hemangioblastoma. Immunoperoxidase-labeled antibody staining resolves the differential diagnosis with metastatic renal cell carcinoma, but does not explain the histogenesis of the capillary hemangioblastoma. Hufnagel, T.J., Kim, J.H., True, L.D., Manuelidis, E.E. Am. J. Surg. Pathol. (1989) [Pubmed]
  5. A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Helms, C., Cao, L., Krueger, J.G., Wijsman, E.M., Chamian, F., Gordon, D., Heffernan, M., Daw, J.A., Robarge, J., Ott, J., Kwok, P.Y., Menter, A., Bowcock, A.M. Nat. Genet. (2003) [Pubmed]
  6. Gut feelings: enteropathogenic E. coli (EPEC) interactions with the host. Goosney, D.L., Gruenheid, S., Finlay, B.B. Annu. Rev. Cell Dev. Biol. (2000) [Pubmed]
  7. Molecular and functional analysis of SDCT2, a novel rat sodium-dependent dicarboxylate transporter. Chen, X., Tsukaguchi, H., Chen, X.Z., Berger, U.V., Hediger, M.A. J. Clin. Invest. (1999) [Pubmed]
  8. Ultrastructural, immunocytochemical, and cytogenetic characterization of a human epithelioid sarcoma cell line (RM-HS1). Reeves, B.R., Fisher, C., Smith, S., Courtenay, V.D., Robertson, D. J. Natl. Cancer Inst. (1987) [Pubmed]
  9. Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes. Langmann, T., Moehle, C., Mauerer, R., Scharl, M., Liebisch, G., Zahn, A., Stremmel, W., Schmitz, G. Gastroenterology (2004) [Pubmed]
  10. The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells. Kang, J.X., Man, S.F., Brown, N.E., Labrecque, P.A., Clandinin, M.T. Biochem. J. (1992) [Pubmed]
  11. GalNAc glycoprotein expression by breast cell lines, primary breast cancer and normal breast epithelial membrane. Brooks, S.A., Hall, D.M., Buley, I. Br. J. Cancer (2001) [Pubmed]
  12. Stereo-specificity for pro-(R) hydrogen of NAD(P)H during enzyme-catalyzed hydride transfer to CL-20. Bhushan, B., Halasz, A., Hawari, J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  13. Immunohistochemical characterization of keratin expression in clear cell acanthoma. Ohnishi, T., Watanabe, S. Br. J. Dermatol. (1995) [Pubmed]
  14. Amino-terminal dimerization of an erythropoietin mimetic peptide results in increased erythropoietic activity. Johnson, D.L., Farrell, F.X., Barbone, F.P., McMahon, F.J., Tullai, J., Kroon, D., Freedy, J., Zivin, R.A., Mulcahy, L.S., Jolliffe, L.K. Chem. Biol. (1997) [Pubmed]
  15. Identification of a 13 amino acid peptide mimetic of erythropoietin and description of amino acids critical for the mimetic activity of EMP1. Johnson, D.L., Farrell, F.X., Barbone, F.P., McMahon, F.J., Tullai, J., Hoey, K., Livnah, O., Wrighton, N.C., Middleton, S.A., Loughney, D.A., Stura, E.A., Dower, W.J., Mulcahy, L.S., Wilson, I.A., Jolliffe, L.K. Biochemistry (1998) [Pubmed]
  16. cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family. Chen, Y., Medvedev, A., Ruzanov, P., Marvin, K.W., Jetten, A.M. Genomics (1997) [Pubmed]
  17. B4B, a novel growth-arrest gene, is expressed by a subset of progenitor/pre-B lymphocytes negative for cytoplasmic mu-chain. Ruegg, C.L., Wu, H.Y., Fagnoni, F.F., Engleman, E.G., Laus, R. J. Immunol. (1996) [Pubmed]
  18. Effect of barrier-breaking agents on intracellular pH and epithelial membrane resistances: studies in isolated Necturus antral mucosa exposed to luminal acid. Kiviluoto, T., Mustonen, H., Kivilaakso, E. Gastroenterology (1989) [Pubmed]
  19. CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia. Parkos, C.A., Colgan, S.P., Liang, T.W., Nusrat, A., Bacarra, A.E., Carnes, D.K., Madara, J.L. J. Cell Biol. (1996) [Pubmed]
  20. HIV-1 gp41 envelope residues 650-685 exposed on native virus act as a lectin to bind epithelial cell galactosyl ceramide. Alfsen, A., Bomsel, M. J. Biol. Chem. (2002) [Pubmed]
  21. Cutaneous parachordoma. A light microscopic and immunohistochemical report of two cases and review of the literature. Imlay, S.P., Argenyi, Z.B., Stone, M.S., McCollough, M.L., Henghold, W.B. J. Cutan. Pathol. (1998) [Pubmed]
  22. CXCR4 and SDF1 expression in human meningiomas: A proliferative role in tumoral meningothelial cells in vitro. Bajetto, A., Barbieri, F., Pattarozzi, A., Dorcaratto, A., Porcile, C., Ravetti, J.L., Zona, G., Spaziante, R., Schettini, G., Florio, T. Neuro-oncology (2007) [Pubmed]
  23. Epidermal growth factor activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases. Wolfgang, C.L., Lin, C., Meng, Q., Karinch, A.M., Vary, T.C., Pan, M. J. Gastrointest. Surg. (2003) [Pubmed]
  24. New epoetin molecules and novel therapeutic approaches. Barbone, F.P., Johnson, D.L., Farrell, F.X., Collins, A., Middleton, S.A., McMahon, F.J., Tullai, J., Jolliffe, L.K. Nephrol. Dial. Transplant. (1999) [Pubmed]
  25. Transport of an Mr approximately 300,000 Plasmodium falciparum protein (Pf EMP 2) from the intraerythrocytic asexual parasite to the cytoplasmic face of the host cell membrane. Howard, R.J., Lyon, J.A., Uni, S., Saul, A.J., Aley, S.B., Klotz, F., Panton, L.J., Sherwood, J.A., Marsh, K., Aikawa, M. J. Cell Biol. (1987) [Pubmed]
  26. Localization of a gene for progressive myoclonus epilepsy to chromosome 21q22. Lehesjoki, A.E., Koskiniemi, M., Sistonen, P., Miao, J., Hästbacka, J., Norio, R., de la Chapelle, A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  27. Thymic carcinoma arising in thymoma is associated with alterations in immunohistochemical profile. Kuo, T.T., Chan, J.K. Am. J. Surg. Pathol. (1998) [Pubmed]
  28. Lymphocyte predominance Hodgkin's disease: lineage and clonality determination using a single-cell assay. Delabie, J., Tierens, A., Wu, G., Weisenburger, D.D., Chan, W.C. Blood (1994) [Pubmed]
  29. Carcinoembryonic antigen expression of resurgent human colon carcinoma after treatment with therapeutic doses of 90Y-alpha-carcinoembryonic antigen monoclonal antibody. Esteban, J.M., Kuhn, J.A., Felder, B., Wong, J.Y., Battifora, H., Beatty, J.D., Wanek, P.M., Shively, J.E. Cancer Res. (1991) [Pubmed]
  30. Cytologic characteristics of meningeal carcinomatosis: increased diagnostic accuracy using carcinoembryonic antigen and epithelial membrane antigen immunocytochemistry. Jorda, M., Ganjei-Azar, P., Nadji, M. Arch. Neurol. (1998) [Pubmed]
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