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Chemical Compound Review

Achromycin     (2Z,4S,4aS,5aS,12aS)-2- (amino-hydroxy...

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Disease relevance of Achromycin

  • A lambda phage (lambdaNK55) carrying the translocatable element Tn10, conferring tetracycline resistance (Tetr), has been utilized to isolate glutamine auxotrophs of Escherichia coli K-12 [1].
  • The in vitro findings were further substantiated with the in vivo effects of Pr along with Tc using Salmonella typhimurium NCTC 74 as the challenge strain in mice [2].
  • It was observed that Pr in combination with tetracycline (Tc) demonstrated a marked enhancement of the inhibitory capacity of each drug, both against the Gram-positive and Gram-negative bacteria, following disc diffusion technique [2].
  • CONCLUSIONS: A Tet- (or Dox-) regulated recombinant adenovirus carrying eNOS was successfully generated and controllable expression of eNOS in ESMC was achieved, which provides some material for conducting further gene therapy studies with eNOS [3].

High impact information on Achromycin

  • In the presence of Tc, PG production in COX-depleted cells was reduced 99.8% compared with either uninduced transfectants or parental HCA-7 cells [4].
  • The cytokinesis-block micronucleus (CBMN) assay is the most extensively used method for measuring MN in human lymphocytes, and can be considered as a "cytome" assay covering cell proliferation, cell death and chromosomal changes [5].
  • The induction of SSeCKS (removal of tet) caused significant cell flattening and the elaboration of an SSeCKS-associated cortical cytoskeletal matrix resistant to Triton X-100 extraction [6].
  • Cytomics, the human cytome project and systems biology: top-down resolution of the molecular biocomplexity of organisms by single cell analysis [7].
  • As with genomics and proteomics before, this discipline requires novel and innovative techniques and technologies to focus on its substrate of research--the cytome [8].

Biological context of Achromycin


  1. Regulation of glutamine synthetase formation in Escherichia coli: characterization of mutants lacking the uridylyltransferase. Bloom, F.R., Levin, M.S., Foor, F., Tyler, B. J. Bacteriol. (1978) [Pubmed]
  2. Studies on the existence of synergism between different antibiotics and a phenothiazine tranquilizer, promazine, possessing antimicrobial property. Dastidar, S.G., Chakraborty, P., Mookerjee, M., Ganguly, M., Chakrabarty, A.N. Acta microbiologica et immunologica Hungarica. (1994) [Pubmed]
  3. Construction of a recombinant adenovirus carrying endothelial nitric oxide synthase gene and its expression and control in esophageal smooth muscle cells. Ning, S.B., Zhang, Z.B., Xie, W.F., Xin, S.L. Chinese journal of digestive diseases. (2004) [Pubmed]
  4. Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells. Chinery, R., Coffey, R.J., Graves-Deal, R., Kirkland, S.C., Sanchez, S.C., Zackert, W.E., Oates, J.A., Morrow, J.D. Cancer Res. (1999) [Pubmed]
  5. Chromosomal changes: induction, detection methods and applicability in human biomonitoring. Mateuca, R., Lombaert, N., Aka, P.V., Decordier, I., Kirsch-Volders, M. Biochimie (2006) [Pubmed]
  6. Control of cytoskeletal architecture by the src-suppressed C kinase substrate, SSeCKS. Gelman, I.H., Lee, K., Tombler, E., Gordon, R., Lin, X. Cell Motil. Cytoskeleton (1998) [Pubmed]
  7. Cytomics, the human cytome project and systems biology: top-down resolution of the molecular biocomplexity of organisms by single cell analysis. Valet, G. Cell Prolif. (2005) [Pubmed]
  8. Microscopy-based multicolor tissue cytometry at the single-cell level. Ecker, R.C., Steiner, G.E. Cytometry. Part A : the journal of the International Society for Analytical Cytology. (2004) [Pubmed]
  9. Cytokinesis-block micronucleus assay evolves into a "cytome" assay of chromosomal instability, mitotic dysfunction and cell death. Fenech, M. Mutat. Res. (2006) [Pubmed]
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