Disease relevance of Blood Platelet Disorders

• These include thrombocytopenia or thrombocytopathy, anemia, leukopenia, and deficiencies of plasmatic factors such as von Willebrand factor (vWF), fibrinogen, the lupus anticoagulant, and factor V. The BT can be used as screening test for patients with bleeding symptoms [1].
• A thrombocytopathy was created in the dogs belonging to groups 1-5 by intravenous administration of 20 mg/kg body weight (BW) acetylsalicylic acid (ASA) [2].
• Hemodialysis, erythropoietin and megakaryocytopoiesis: factors in uremic thrombocytopathy and thrombophilia [3].

High impact information on Blood Platelet Disorders

• Uraemic thrombocytopathy and parathyroid hormone [4].
• Authors assumed that melphalan acts as a specific inhibitor of release reaction and can induce an acquired thrombocytopathy [5].
• A separate analysis of sensitivity by type of platelet defect, ASA use versus congenital thrombocytopathies, revealed for the PFA-100 system a 94.5% sensitivity in identifying ASA users and a 95.9% sensitivity in identifying the other defects [6].
• Previous experience has shown that CEPI cartridges detect qualitative platelet defects, including acetylsalicylic acid (ASA)-induced abnormalities, while CADP cartridges detect only thrombocytopathies and not ASA use [6].
• Constitutional thrombocytopathy with subnormal response to thromboxane A2 [7].

Chemical compound and disease context of Blood Platelet Disorders

• In thrombocyte vascular hemostasis, thrombocytopathy was observed with increased adenosine-5-diphosphate aggregation and the inhibition of the inner mechanism with fibrinolysis and endotheliosis [8].
• Amiodarone-induced thrombocytopathy [9].
• The patients showed a different degree of thrombocytopathy expressed by impaired adhesiveness, epinephrine-induced aggregation and platelet factor 3 availability [10].

Gene context of Blood Platelet Disorders

• Lack of evidence for the role of secondary hyperparathyroidism in the pathogenesis of uremic thrombocytopathy [11].
• Our studies confirm that MKL is often accompanied by a thrombocytopathy which should be taken into account in the management of these patients [12].

References