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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Adhesiveness


High impact information on Adhesiveness

  • These results suggest that tyrosine phosphorylation-dependent signalling pathways regulated by PTP-sigma influence the proliferation and/or adhesiveness of various cell types in the developing hypothalamo-pituitary axis [6].
  • We show that terminal differentiation in culture involves loss of adhesiveness to fibronectin, laminin, and collagen types I and IV [7].
  • Another trypsin inhibitor, TLCK, although it did not inhibit fibrinolysis, was very effective at restoring adhesiveness and morphology as well as hexose transport to normal [8].
  • Addition of the trypsin inhibitors NPGB or Soy Bean Trypsin Inhibitor at concentrations which inhibited transformation-associated fibrinolysis restored adhesiveness and morphology to near normal, but did not affect the rate of hexose transport [8].
  • Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness [9].

Chemical compound and disease context of Adhesiveness


Biological context of Adhesiveness

  • The observed inhibition by ANP of FMLP-stimulated chemotaxis of PMN may be due to their enhanced adhesiveness [15].
  • To examine the role of complement components as regulators of the expression of endothelial adhesive molecules in response to immune complexes (ICs), we determined whether ICs stimulate both endothelial adhesiveness for leukocytes and expression of E-selectin and intercellular and vascular cell adhesion molecules 1 (ICAM-1 and VCAM-1) [16].
  • The defect in adhesion appears to be responsible for the change in cell shape, since the mutant cells become flattened and look similar to wild-type cells when treated with dibutyryl cyclic AMP even though their adhesiveness remains decreased [17].
  • Furthermore, Tyr AG490 inhibited rapid CCL21-mediated up-regulation of alpha4 and beta2 integrin adhesiveness in static adhesion assays and under physiological flow, whereas adhesion induced by phorbol myristate acetate remained unaltered [18].
  • Phosphorylation of the protein was not sufficient for morphological alterations, increased hexose transport, or loss of adhesiveness [19].

Anatomical context of Adhesiveness


Associations of Adhesiveness with chemical compounds

  • Thus we were able to separate the appearance of transformation-specific changes in morphology and adhesiveness (which apparently require fibrinolytic activity) from the increased rate of hexose transport (which is independent of fibrinolytic activity) [8].
  • Treatment of HuVEC with interleukin 1, tumor necrosis factor (TNF), bacterial endotoxin, and 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in time and dose-dependent increases of adhesiveness for basophils [25].
  • However, preincubation of PMN with TNF in suspension led to a decrease in cellular adhesiveness, degranulation, and burst activity in response to a secondary stimulus of TNF under adherent conditions, although cells remained fully responsive toward phorbol myristate acetate [26].
  • The mutual adhesiveness of HeLa cells harvested from density-inhibited suspension cultures was significantly enhanced by the addition of putrescine [27].
  • Cultivation of B77 virus-transformed rat cells in the presence of dibutyryl cyclic AMP and theophylline led to as much as a sevenfold increase in the level of APF activity appearing in the culture medium, with a concomitant increase in the adhesiveness of the cells to the culture substratum [28].

Gene context of Adhesiveness


Analytical, diagnostic and therapeutic context of Adhesiveness


  1. Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Tsao, P.S., McEvoy, L.M., Drexler, H., Butcher, E.C., Cooke, J.P. Circulation (1994) [Pubmed]
  2. Interleukin-18 binding protein reduces b16 melanoma hepatic metastasis by neutralizing adhesiveness and growth factors of sinusoidal endothelium. Carrascal, M.T., Mendoza, L., Valcárcel, M., Salado, C., Egilegor, E., Tellería, N., Vidal-Vanaclocha, F., Dinarello, C.A. Cancer Res. (2003) [Pubmed]
  3. Human endothelial cell adhesiveness for neutrophils, induced by Escherichia coli lipopolysaccharide in vitro, is inhibited by Bacteroides fragilis lipopolysaccharide. Magnuson, D.K., Weintraub, A., Pohlman, T.H., Maier, R.V. J. Immunol. (1989) [Pubmed]
  4. Tumor cell-endothelial interactions. Increased adhesion of human melanoma cells to activated vascular endothelium. Rice, G.E., Gimbrone, M.A., Bevilacqua, M.P. Am. J. Pathol. (1988) [Pubmed]
  5. Increased endothelial cell adherence, aggregation, and superoxide generation by neutrophils incubated in systemic lupus erythematosus and Felty's syndrome sera. Hashimoto, Y., Ziff, M., Hurd, E.R. Arthritis Rheum. (1982) [Pubmed]
  6. Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma. Elchebly, M., Wagner, J., Kennedy, T.E., Lanctôt, C., Michaliszyn, E., Itié, A., Drouin, J., Tremblay, M.L. Nat. Genet. (1999) [Pubmed]
  7. Changes in keratinocyte adhesion during terminal differentiation: reduction in fibronectin binding precedes alpha 5 beta 1 integrin loss from the cell surface. Adams, J.C., Watt, F.M. Cell (1990) [Pubmed]
  8. Inhibition of protease activity in cultures of rous sarcoma virus-transformed cells: effect on the transformed phenotype. Weber, M.J. Cell (1975) [Pubmed]
  9. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Palecek, S.P., Loftus, J.C., Ginsberg, M.H., Lauffenburger, D.A., Horwitz, A.F. Nature (1997) [Pubmed]
  10. Amino acid residue Ala-62 in the FimH fimbrial adhesin is critical for the adhesiveness of meningitis-associated Escherichia coli to collagens. Pouttu, R., Puustinen, T., Virkola, R., Hacker, J., Klemm, P., Korhonen, T.K. Mol. Microbiol. (1999) [Pubmed]
  11. Effects of dibutyryl cyclic AMP on the syntheses of dolichol-linked saccharides and glycoproteins in cultured hepatoma cells. Correlation with the effect on the adhesiveness of the cells. Okamoto, Y., Sakai, H., Sato, J., Akamatsu, N. Biochem. J. (1983) [Pubmed]
  12. Retinoic acid enhances adhesiveness, laminin and integrin beta 1 synthesis, and retinoic acid receptor expression in F9 teratocarcinoma cells. Ross, S.A., Ahrens, R.A., De Luca, L.M. J. Cell. Physiol. (1994) [Pubmed]
  13. Leptospira icterohemorrhagiae and leptospire peptidolgycans induce endothelial cell adhesiveness for polymorphonuclear leukocytes. Dobrina, A., Nardon, E., Vecile, E., Cinco, M., Patriarca, P. Infect. Immun. (1995) [Pubmed]
  14. Effects on retinal adhesive force in vivo of metabolically active agents in the subretinal space. Kita, M., Marmor, M.F. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  15. Priming of polymorphonuclear neutrophils by atrial natriuretic peptide in vitro. Wiedermann, C.J., Niedermühlbichler, M., Braunsteiner, H., Widermann, C.J. J. Clin. Invest. (1992) [Pubmed]
  16. Identification of C1q as the heat-labile serum cofactor required for immune complexes to stimulate endothelial expression of the adhesion molecules E-selectin and intercellular and vascular cell adhesion molecules 1. Lozada, C., Levin, R.I., Huie, M., Hirschhorn, R., Naime, D., Whitlow, M., Recht, P.A., Golden, B., Cronstein, B.N. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  17. Mutants of Balb/c 3T3 fibroblasts defective in adhesiveness to substratum: evidence for alteration in cell surface proteins. Pouysségur, J.M., Pastan, I. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  18. CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway. Stein, J.V., Soriano, S.F., M'rini, C., Nombela-Arrieta, C., de Buitrago, G.G., Rodríguez-Frade, J.M., Mellado, M., Girard, J.P., Martínez-A, C. Blood (2003) [Pubmed]
  19. Phosphorylation of a 36,000 Mr cellular protein in cells infected with partial transformation mutants of rous sarcoma virus. Nakamura, K.D., Weber, M.J. Mol. Cell. Biol. (1982) [Pubmed]
  20. Leukosialin (CD43)-major histocompatibility class I molecule interactions involved in spontaneous T cell conjugate formation. Stöckl, J., Majdic, O., Kohl, P., Pickl, W.F., Menzel, J.E., Knapp, W. J. Exp. Med. (1996) [Pubmed]
  21. Cultured human endothelial cells stimulated with cytokines or endotoxin produce an inhibitor of leukocyte adhesion. Wheeler, M.E., Luscinskas, F.W., Bevilacqua, M.P., Gimbrone, M.A. J. Clin. Invest. (1988) [Pubmed]
  22. C5a-induced expression of P-selectin in endothelial cells. Foreman, K.E., Vaporciyan, A.A., Bonish, B.K., Jones, M.L., Johnson, K.J., Glovsky, M.M., Eddy, S.M., Ward, P.A. J. Clin. Invest. (1994) [Pubmed]
  23. Human monocyte colony-stimulating factor stimulates the gene expression of monocyte chemotactic protein-1 and increases the adhesion of monocytes to endothelial monolayers. Shyy, Y.J., Wickham, L.L., Hagan, J.P., Hsieh, H.J., Hu, Y.L., Telian, S.H., Valente, A.J., Sung, K.L., Chien, S. J. Clin. Invest. (1993) [Pubmed]
  24. Membrane-mediated drug resistance and phenotypic reversion to normal growth behavior of Chinese hamster cells. Biedler, J.L., Riehm, H., Peterson, R.H., Spengler, B.A. J. Natl. Cancer Inst. (1975) [Pubmed]
  25. Adherence of human basophils to cultured umbilical vein endothelial cells. Bochner, B.S., Peachell, P.T., Brown, K.E., Schleimer, R.P. J. Clin. Invest. (1988) [Pubmed]
  26. The tumor necrosis factor receptor and human neutrophil function. Deactivation and cross-deactivation of tumor necrosis factor-induced neutrophil responses by receptor down-regulation. Schleiffenbaum, B., Fehr, J. J. Clin. Invest. (1990) [Pubmed]
  27. Putrescine-promoted mutual adhesiveness of HeLa cells from density-inhibited suspension cultures. Deman, J., Bruyneel, E. J. Natl. Cancer Inst. (1977) [Pubmed]
  28. Cell to substratum adhesion-promoting activity released by normal and virus-transformed cells in culture. Moore, E.G. J. Cell Biol. (1976) [Pubmed]
  29. Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses. de Fougerolles, A.R., Qin, X., Springer, T.A. J. Exp. Med. (1994) [Pubmed]
  30. Adherence of neutrophils to canine cardiac myocytes in vitro is dependent on intercellular adhesion molecule-1. Smith, C.W., Entman, M.L., Lane, C.L., Beaudet, A.L., Ty, T.I., Youker, K., Hawkins, H.K., Anderson, D.C. J. Clin. Invest. (1991) [Pubmed]
  31. A novel role for p120 catenin in E-cadherin function. Ireton, R.C., Davis, M.A., van Hengel, J., Mariner, D.J., Barnes, K., Thoreson, M.A., Anastasiadis, P.Z., Matrisian, L., Bundy, L.M., Sealy, L., Gilbert, B., van Roy, F., Reynolds, A.B. J. Cell Biol. (2002) [Pubmed]
  32. Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants. Barbara, J.A., Smith, W.B., Gamble, J.R., Van Ostade, X., Vandenabeele, P., Tavernier, J., Fiers, W., Vadas, M.A., Lopez, A.F. EMBO J. (1994) [Pubmed]
  33. Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium. Wong, M.H., Hermiston, M.L., Syder, A.J., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  34. Homophilic adhesion of the myelin P0 protein requires glycosylation of both molecules in the homophilic pair. Filbin, M.T., Tennekoon, G.I. J. Cell Biol. (1993) [Pubmed]
  35. Interactions between germ cells and extracellular matrix glycoproteins during migration and gonad assembly in the mouse embryo. García-Castro, M.I., Anderson, R., Heasman, J., Wylie, C. J. Cell Biol. (1997) [Pubmed]
  36. Plasma cholesterol regulates soluble cell adhesion molecule expression in familial hypercholesterolemia. Sampietro, T., Tuoni, M., Ferdeghini, M., Ciardi, A., Marraccini, P., Prontera, C., Sassi, G., Taddei, M., Bionda, A. Circulation (1997) [Pubmed]
  37. Neutrophil adhesiveness during prostacyclin and heparin hemodialysis. Spagnuolo, P.J., Bass, S.H., Smith, M.C., Danviriyasup, K., Dunn, M.J. Blood (1982) [Pubmed]
  38. The CD81 tetraspanin facilitates instantaneous leukocyte VLA-4 adhesion strengthening to vascular cell adhesion molecule 1 (VCAM-1) under shear flow. Feigelson, S.W., Grabovsky, V., Shamri, R., Levy, S., Alon, R. J. Biol. Chem. (2003) [Pubmed]
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