Disease relevance of Splenic Rupture

• Clinically detectable splenomegaly and splenic rupture are uncommon but potentially life-threatening consequences of G-CSF administration [1].
• An extremely rare case of splenic rupture at the site of metastasis of hepatocellular carcinoma is reported [2].
• Splenic rupture can be one of the causes of hemoperitoneum in patients with hepatocellular carcinoma [2].
• Nonketotic hyperosmolar coma associated with splenic rupture in congenital afibrinogenemia [3].
• Splenic rupture in AL amyloidosis as a complication of aggressive treatment with HDM/SCT has not been reported previously [4].

High impact information on Splenic Rupture

• Splenic rupture in association with WG, however, is rare [5].
• Spontaneous splenic rupture in a patient with large hepatocellular carcinoma [6].
• Pain of delayed traumatic splenic rupture masked by intrapleural lidocaine [7].
• We herein provide the characteristics of this rarely documented causal relationship between heparin and spontaneous splenic rupture and retrospectively review similar cases in the literature [8].
• A case of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma presenting with spontaneous splenic rupture: an extremely unusual presentation [9].

Gene context of Splenic Rupture

• The splenic rupture is attributed to amyloid involvement of the spleen [10].
• Two cases of maternal antenatal splenic rupture and hypotension associated with Moebius syndrome and cerebral palsy in offspring. Further evidence for a utero placental vascular aetiology for the Moebius syndrome and some cases of cerebral palsy [11].
• Congenital diaphragmatic hernia presenting as splenic rupture in an adult [12].
• Splenic rupture in acute megakaryoblastic leukemia [13].

Analytical, diagnostic and therapeutic context of Splenic Rupture

• Spontaneous splenic rupture associated with thrombolytic therapy and/or concomitant heparin anticoagulation [14].

References