Disease relevance of Duodenal Diseases

• This study investigates transfer of functional wild-type adenomatous polyposis coli (APC) gene under conditions of varying pH and bile concentrations into a somatic duodenal cancer cell line (HUTU-80) as a prelude to in vivo gene therapy in the management of severe duodenal disease [1].
• These findings showed serum gastrin levels, H.-pylori-infection, gastritis and duodenal disease in the uremic patients to be higher than those of the control group [2].
• METHODOLOGY: The study was performed in 172 patients: with gastric and duodenal ulcer, after Billroth I and Billroth II gastrectomy, with gastroesophageal reflux, after cholecystectomy, with chronic cholecystitis and chronic duodenal disease [3].

High impact information on Duodenal Diseases

• CE should be performed in FAP patients with stage III and IV duodenal disease [4].
• Duodenal H. pylori ureA was significantly more frequent in patients with duodenal diseases than in those without (p <.01), cagA positive strains being mainly involved in the infection of this anatomical area (p <.01) [5].
• Increased prevalence of iceA1 and cagE were observed in children with duodenal disease, although it did not reach significance [6].
• Twelve patients had normal lactase activity, despite the presence of duodenal disease [7].
• Conversely the amount of luminal acid correlates with the incidence of stress-induced duodenal disease but does not seem to play a role in determining the severity of the duodenal disease after it has begun [8].

References