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MeSH Review:

Duodenal Neoplasms

Weese, J.L. et al., Qu, X. et al., Gallagher, M.C. et al., Spigelman, A.D. et al., Murakami, Y. et al., et al.

Murakami, Uemura, Sasaki, Morifuji, Hayashidani, Sudo, Sueda,

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Disease relevance of Duodenal Neoplasms

BACKGROUND: Although only 5 per cent of patients with familial adenomatous polyposis (FAP) die from duodenal cancer, a recent study indicated that the mortality rate is much higher in patients with Spigelman stage IV disease [1].
Fifteen patients with pancreatic cancer (14 head, 1 body) and 1 patient with duodenal cancer, (with paraaortic adenopathy), were subjected to combination treatment with infusional 5-FU, bolus injection of mitomycin-C, and XRT (4 patients were treated off the protocol) [2].

High impact information on Duodenal Neoplasms

These abnormalities could be used as an intermediate biomarker for chemoprevention studies of duodenal cancer in FAP [3].
Here, we demonstrated hGRP-R activation stimulated sustained cyclic AMP response element binding protein (CREB) phosphorylation and transactivation in duodenal cancer cells through a protein kinase C and partially p38 mitogen-activated protein kinase-dependent pathway [4].
Steady state hGRP-R mRNA can also be detected in some cultured cells from breast, lung, and duodenal cancer [5].
Indeed orotic acid has also been found to promote duodenal cancer [6].

Biological context of Duodenal Neoplasms

There was no association between duodenal cancer and site of germline mutation of the APC gene [7].

Anatomical context of Duodenal Neoplasms

This report suggests that resection of the total duodenum is essential for duodenal neoplasms in FAP to prevent a recurrence in the remaining duodenum [8].
RESULTS--Adenomatous tissue was found within duodenal cancer in 29 of 44 (66%) patients with FAP and in mucosa adjacent to duodenal cancer in 31 of 42 (73%) such patients [9].

Analytical, diagnostic and therapeutic context of Duodenal Neoplasms

We speculated that 2-((18)F)-fluoro-2-deoxy-D: -glucose positron emission tomography (FDG-PET) might be able to detect early duodenal cancer in FAP [10].

References

Pylorus-preserving pancreaticoduodenectomy for advanced duodenal disease in familial adenomatous polyposis. Gallagher, M.C., Shankar, A., Groves, C.J., Russell, R.C., Phillips, R.K. The British journal of surgery. (2004) [Pubmed]
Increased resectability of locally advanced pancreatic and periampullary carcinoma with neoadjuvant chemoradiotherapy. Weese, J.L., Nussbaum, M.L., Paul, A.R., Engstrom, P.F., Solin, L.J., Kowalyshyn, M.J., Hoffman, J.P. Int. J. Pancreatol. (1990) [Pubmed]
Cell proliferation of the duodenal mucosa in patients affected by familial adenomatous polyposis. Santucci, R., Volpe, L., Zannoni, U., Paganelli, G.M., Poggi, B., Calabrese, C., Biasco, G. Gastroenterology (1997) [Pubmed]
Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells. Qu, X., Xiao, D., Weber, H.C. FEBS Lett. (2002) [Pubmed]
The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter. Xiao, D., Wang, J., Hampton, L.L., Weber, H.C. Gene (2001) [Pubmed]
Liver tumour promotion by chemicals: models and mechanisms. Sarma, D.S., Rao, P.M., Rajalakshmi, S. Cancer Surv. (1986) [Pubmed]
Duodenal cancer in patients with familial adenomatous polyposis (FAP): results of a 10 year prospective study. Groves, C.J., Saunders, B.P., Spigelman, A.D., Phillips, R.K. Gut (2002) [Pubmed]
Duodenal cancer arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for ampullary cancer in familial adenomatous polyposis. Murakami, Y., Uemura, K., Sasaki, M., Morifuji, M., Hayashidani, Y., Sudo, T., Sueda, T. J. Gastrointest. Surg. (2005) [Pubmed]
Evidence for adenoma-carcinoma sequence in the duodenum of patients with familial adenomatous polyposis. The Leeds Castle Polyposis Group (Upper Gastrointestinal Committee). Spigelman, A.D., Talbot, I.C., Penna, C., Nugent, K.P., Phillips, R.K., Costello, C., DeCosse, J.J. J. Clin. Pathol. (1994) [Pubmed]
Ability of FDG-PET to detect all cancers in patients with familial adenomatous polyposis, and impact on clinical management. van Kouwen, M.C., Drenth, J.P., van Krieken, J.H., van Goor, H., Friederich, P., Oyen, W.J., Nagengast, F.M. Eur. J. Nucl. Med. Mol. Imaging (2006) [Pubmed]

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