Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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MeSH Review:

Femur Neck

Fonseca, D. et al., Bhattoa, H.P. et al., Fleet, J.C. et al., Tümer, L. et al., Shapiro, J.R. et al., et al.

Stepan, Burckhardt, Hána, Erbayat Altay, Serdaroğlu, Tümer, Gücüyener, Hasanoğlu,

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Disease relevance of Femur Neck

Dual energy X-ray absorptiometry (DEXA) was used to assess lumbar spine (L2-4) and femur neck BMD in 40 children aged 9-15 years, taking L-thyroxine (100 micrograms/m2/day) for a mean period of 1.45 +/- 0.60 years for colloid diffuse goiter [1].

High impact information on Femur Neck

White (n = 83) and black (n = 72) women between 20 and 40 years of age were genotyped based on the presence (b) or absence (B) of a BsmI restriction enzyme site in the VDR gene, and BMD in the lumbar spine and femur neck was determined for each subject [2].
In 535 subjects with duplicate scans, age 20-91 of both sexes, examined in a blinded review, precision for BMD at the femur neck ROI was 3.2% (CV) and 5.1% for Ward's triangle BMD [3].
We determined serum levels of 25-hydroxyvitamin D (25-OH-D), PTH, osteocalcin (OC), degradation products of C-terminal telopeptides of type-I collagen (CTx), dietary calcium intake and BMD at L2-L4 lumbar spine (LS) and femur neck (FN) in 319 randomly selected ambulatory postmenopausal women [4].
The objective of this study was to determine the effects of purified daidzein in combination with high calcium (Ca) on preserving femur and lumbar vertebrae (LV1-LV4) bone mineral density (BMD) and biomechanical bone strength at three different sites (femur midpoint, femur neck and LV3) in ovariectomized mice [5].
After the discontinuation of treatment, serum CTX and PINP increased to the pretreatment levels, and the lumbar spine and femur neck BMD decreased (P < 0.05) [6].

Associations of Femur Neck with chemical compounds

Pamidronate treatment led to significant increases in bone mineral density (BMD), measured by DXA, in the lumbar spine at 12 months (P = 0.05) and in the femur neck (P = 0.02) at 24 months [7].
BMD values at both the femur neck and lumbar spine in both the carbamazepine and valproic acid groups were not significantly different from that of the control group [8].

Gene context of Femur Neck

About 20% of USA women aged 50-79 years had BMD levels for the lumbar spine, or for the femur neck, more than -2.5 SD below the average values in young adult women 20-39 years old [9].

References

Bone mineral density and metabolism in children treated with L-thyroxine. Tümer, L., Hasanoğlu, A., Cinaz, P., Bideci, A. Journal of pediatric endocrinology & metabolism : JPEM. (1999) [Pubmed]
The BsmI vitamin D receptor restriction fragment length polymorphism (BB) predicts low bone density in premenopausal black and white women. Fleet, J.C., Harris, S.S., Wood, R.J., Dawson-Hughes, B. J. Bone Miner. Res. (1995) [Pubmed]
Quality control of bone densitometry in a national health survey (NHANES III) using three mobile examination centers. Wahner, H.W., Looker, A., Dunn, W.L., Walters, L.C., Hauser, M.F., Novak, C. J. Bone Miner. Res. (1994) [Pubmed]
Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women. Bhattoa, H.P., Bettembuk, P., Ganacharya, S., Balogh, A. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2004) [Pubmed]
Daidzein together with high calcium preserve bone mass and biomechanical strength at multiple sites in ovariectomized mice. Fonseca, D., Ward, W.E. Bone (2004) [Pubmed]
The effects of three-month intravenous ibandronate on bone mineral density and bone remodeling in Klinefelter's syndrome: the influence of vitamin D deficiency and hormonal status. Stepan, J.J., Burckhardt, P., Hána, V. Bone (2003) [Pubmed]
The effect of intravenous pamidronate on bone mineral density, bone histomorphometry, and parameters of bone turnover in adults with type IA osteogenesis imperfecta. Shapiro, J.R., McCarthy, E.F., Rossiter, K., Ernest, K., Gelman, R., Fedarko, N., Santiago, H.T., Bober, M. Calcif. Tissue Int. (2003) [Pubmed]
Evaluation of bone mineral metabolism in children receiving carbamazepine and valproic acid. Erbayat Altay, E., Serdaroğlu, A., Tümer, L., Gücüyener, K., Hasanoğlu, A. Journal of pediatric endocrinology & metabolism : JPEM. (2000) [Pubmed]
Bone density of the spine and femur in adult white females. Mazess, R.B., Barden, H. Calcif. Tissue Int. (1999) [Pubmed]

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