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MeSH Review

Lumbar Vertebrae

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Disease relevance of Lumbar Vertebrae


Psychiatry related information on Lumbar Vertebrae


High impact information on Lumbar Vertebrae

  • In addition, the Shp-2 mutation caused multiple developmental defects in chimeric mice, characterized by short hind legs, aberrant limb features, split lumbar vertebrae, abnormal rib patterning, and pathological changes in the lungs, intestines, and skin [7].
  • Our analysis of single mutants reveals common features for the Hoxc8 and Hoxd8 genes in patterning lower thoracic and lumbar vertebrae [8].
  • Targeted deletion of the gene for GDF11, a novel member of the TGFbeta family, has been found to cause an increase in the number of thoracic and lumbar vertebrae in the mouse [9].
  • MATERIALS AND METHODS: Changes in trabecular bone structure, elastic modulus, and mineral to matrix ratio of the fifth lumbar vertebrae was assessed in prednisolone-treated mice and placebo-treated controls for comparison with estrogen-deficient mice and sham-operated controls [10].
  • RESULTS: Morphometric evaluation of lumbar vertebrae (L(1)-L(4)) showed that the shape of vertebral bodies was better preserved in pamidronate-treated patients [11].

Chemical compound and disease context of Lumbar Vertebrae


Biological context of Lumbar Vertebrae


Anatomical context of Lumbar Vertebrae


Associations of Lumbar Vertebrae with chemical compounds


Gene context of Lumbar Vertebrae

  • Bone histomorphometry showed that the cortical bone area of the mid-diaphysis of the femur and the trabecular bone volume of the lumbar vertebrae were significantly reduced in IL-18 TG mice [14].
  • In the lumbar vertebrae, these stimulatory effects of PTH on trabecular area, trabecular number, and cortical width were smaller and not detected until 7 weeks [28].
  • In addition to serum osteocalcin (BGP) we measured parathyroid hormone (PTH) (carboxyl and mid-molecule fragments), 25(OH)D, alkaline phosphatase, estradiol (E2), estrone (E1), dietary calcium intake, 24 hour urinary calcium excretion, and bone mineral density by CT scan of the lumbar vertebrae [29].
  • In the absence of Hox10 function, no lumbar vertebrae are formed [30].
  • In 5-HTT (-/-) animals, cancellous bone volume (BV/TV) in the lumbar vertebrae is reduced, with a trend toward decreased trabecular thickness and trabecular number [31].

Analytical, diagnostic and therapeutic context of Lumbar Vertebrae


  1. Dual-photon Gd-153 absorptiometry of bone. Wahner, H.W., Dunn, W.L., Mazess, R.B., Towsley, M., Lindsay, R., Markhard, L., Dempster, D. Radiology. (1985) [Pubmed]
  2. Dietary soy protein and isoflavones: minimal beneficial effects on bone and no effect on the reproductive tract of sexually mature ovariectomized Sprague-Dawley rats. Bahr, J.M., Nakai, M., Rivera, A., Walsh, J., Evans, G.L., Lotinun, S., Turner, R.T., Black, M., Jeffery, E.H. Menopause (New York, N.Y.) (2005) [Pubmed]
  3. Bone mineral density of the lumbar vertebrae in children and adolescents with insulin-dependent diabetes mellitus. Ponder, S.W., McCormick, D.P., Fawcett, H.D., Tran, A.D., Ogelsby, G.W., Brouhard, B.H., Travis, L.B. J. Pediatr. (1992) [Pubmed]
  4. Low bone density with normal bone turnover in ovariectomized and streptozotocin-induced diabetic rats. Herrero, S., Calvo, O.M., García-Moreno, C., Martín, E., San Román, J.I., Martín, M., García-Talavera, J.R., Calvo, J.J., del Pino-Montes, J. Calcif. Tissue Int. (1998) [Pubmed]
  5. Effects of 1-year ipriflavone treatment on lumbar bone mineral density and bone metabolic markers in postmenopausal women with low bone mass. Ohta, H., Komukai, S., Makita, K., Masuzawa, T., Nozawa, S. Horm. Res. (1999) [Pubmed]
  6. The validity of the Computer Science and Applications activity monitor for use in coronary artery disease patients during level walking. Ekelund, U., Tingström, P., Kamwendo, K., Krantz, M., Nylander, E., Sjöström, M., Bergdahl, B. Clinical physiology and functional imaging. (2002) [Pubmed]
  7. Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells. Qu, C.K., Yu, W.M., Azzarelli, B., Cooper, S., Broxmeyer, H.E., Feng, G.S. Mol. Cell. Biol. (1998) [Pubmed]
  8. Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes. van den Akker, E., Fromental-Ramain, C., de Graaff, W., Le Mouellic, H., Brûlet, P., Chambon, P., Deschamps, J. Development (2001) [Pubmed]
  9. Axis development: the mouse becomes a dachshund. Gad, J.M., Tam, P.P. Curr. Biol. (1999) [Pubmed]
  10. Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice. Lane, N.E., Yao, W., Balooch, M., Nalla, R.K., Balooch, G., Habelitz, S., Kinney, J.H., Bonewald, L.F. J. Bone Miner. Res. (2006) [Pubmed]
  11. Effects of intravenous pamidronate treatment in infants with osteogenesis imperfecta: clinical and histomorphometric outcome. Munns, C.F., Rauch, F., Travers, R., Glorieux, F.H. J. Bone Miner. Res. (2005) [Pubmed]
  12. Effects of hydrocortisone on the vertebral cartilage plate in mice. A light and electron microscopic study. Higuchi, M., Abe, K. Spine. (1985) [Pubmed]
  13. Long-term effects of withdrawal of bisphosphonate incadronate disodium (YM175) on bone mineral density, mass, structure, and turnover in the lumbar vertebrae of ovariectomized rats. Tamura, Y., Miyakoshi, N., Itoi, E., Abe, T., Kudo, T., Tsuchida, T., Kasukawa, Y., Sato, K. J. Bone Miner. Res. (2001) [Pubmed]
  14. Bone malformations in interleukin-18 transgenic mice. Kawase, Y., Hoshino, T., Yokota, K., Kuzuhara, A., Nakamura, M., Maeda, Y., Nishiwaki, E., Zenmyo, M., Hiraoka, K., Aizawa, H., Yoshino, K. J. Bone Miner. Res. (2003) [Pubmed]
  15. Differential responses of femoral and vertebral bones to long-term excessive L-thyroxine administration in adult rats. Suwanwalaikorn, S., Ongphiphadhanakul, B., Braverman, L.E., Baran, D.T. Eur. J. Endocrinol. (1996) [Pubmed]
  16. Xenopus hoxc8 during early development. Ko, C., Chung, H.M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  17. Experimental study of seita-fitting. Kawahara, M., Sako, H., Sato, H. Journal of human ergology. (1998) [Pubmed]
  18. Bone and mineral metabolism in the adult guinea pig: long-term effects of estrogen and androgen deficiency. Vanderschueren, D., Van Herck, E., Suiker, A.M., Allewaert, K., Visser, W.J., Geusens, P., Bouillon, R. J. Bone Miner. Res. (1992) [Pubmed]
  19. Effects of gallium nitrate in nude mice bearing a canine adenocarcinoma (CAC-8) model of humoral hypercalcemia of malignancy. Merryman, J.I., Capen, C.C., Rosol, T.J. J. Bone Miner. Res. (1994) [Pubmed]
  20. Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse. Boulet, A.M., Capecchi, M.R. Dev. Biol. (2002) [Pubmed]
  21. Does suppression of bone turnover impair mechanical properties by allowing microdamage accumulation? Hirano, T., Turner, C.H., Forwood, M.R., Johnston, C.C., Burr, D.B. Bone (2000) [Pubmed]
  22. Rosiglitazone impacts negatively on bone by promoting osteoblast/osteocyte apoptosis. Sorocéanu, M.A., Miao, D., Bai, X.Y., Su, H., Goltzman, D., Karaplis, A.C. J. Endocrinol. (2004) [Pubmed]
  23. The effects of recombinant human insulin-like growth factor (rhIGF)-1 and rhIGF-1/IGF binding protein-3 administration on rat osteopenia induced by ovariectomy with concomitant bilateral sciatic neurectomy. Narusawa, K., Nakamura, T., Suzuki, K., Matsuoka, Y., Lee, L.J., Tanaka, H., Seino, Y. J. Bone Miner. Res. (1995) [Pubmed]
  24. Dual-energy x-ray absorptiometry of raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats. Sato, M., McClintock, C., Kim, J., Turner, C.H., Bryant, H.U., Magee, D., Slemenda, C.W. J. Bone Miner. Res. (1994) [Pubmed]
  25. Clodronate prevents osteopenia and loss of trabecular connectivity in estrogen-deficient rats. Kippo, K., Hannuniemi, R., Isaksson, P., Laurén, L., Osterman, T., Peng, Z., Tuukkanen, J., Kuurtamo, P., Väänänen, H.K., Sellman, R. J. Bone Miner. Res. (1998) [Pubmed]
  26. There is no difference in spontaneous and 17 beta-estradiol-induced interleukin-1 beta release by peripheral blood mononuclear cells from nonosteoporotic women with different rates of early postmenopausal bone loss. Høgåsen, A.K., Nordsletten, L., Aasen, A.O., Falch, J.A. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  27. Bone loss in patients with chronic renal disease: prediction with quantitative bone scintigraphy with SPECT. Israel, O., Gips, S., Hardoff, R., Rudoy, J., Frajewicki, V., Iosilevsky, G., Bettman, L., Frenkel, A., Hoffman, A., Kolodny, G.M. Radiology. (1995) [Pubmed]
  28. Anabolic action of parathyroid hormone is skeletal site specific at the tissue and cellular levels in mice. Iida-Klein, A., Zhou, H., Lu, S.S., Levine, L.R., Ducayen-Knowles, M., Dempster, D.W., Nieves, J., Lindsay, R. J. Bone Miner. Res. (2002) [Pubmed]
  29. Serum bone gla protein (BGP) and other markers of bone mineral metabolism in postmenopausal osteoporosis. Ismail, F., Epstein, S., Pacifici, R., Droke, D., Thomas, S.B., Avioli, L.V. Calcif. Tissue Int. (1986) [Pubmed]
  30. Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Wellik, D.M., Capecchi, M.R. Science (2003) [Pubmed]
  31. The role of dopamine and serotonin in regulating bone mass and strength: studies on dopamine and serotonin transporter null mice. Bliziotes, M., Gunness, M., Eshleman, A., Wiren, K. Journal of musculoskeletal & neuronal interactions. (2002) [Pubmed]
  32. Osteoporosis after renal transplantation: single center experience. Ugur, A., Guvener, N., Işiklar, I., Turan, M., Erdal, R., Haberal, M. Transplantation (2001) [Pubmed]
  33. Effects of 16 weeks of treatment with tibolone on bone mass and bone mechanical and histomorphometric indices in mature ovariectomized rats with established osteopenia on a low-calcium diet. Yoshitake, K., Yokota, K., Kasugai, Y., Kagawa, M., Sukamoto, T., Nakamura, T. Bone (1999) [Pubmed]
  34. Effects of separate and combined therapy with growth hormone and parathyroid hormone on lumbar vertebral bone in aged ovariectomized osteopenic rats. Wang, L., Orhii, P.B., Banu, J., Kalu, D.N. Bone (2001) [Pubmed]
  35. The role of vascular endothelial growth factor in glucocorticoid-induced bone loss: evaluation in a minipig model. Pufe, T., Scholz-Ahrens, K.E., Franke, A.T., Petersen, W., Mentlein, R., Varoga, D., Tillmann, B., Schrezenmeir, J., Glüer, C.C. Bone (2003) [Pubmed]
  36. Replacement of the lumbar vertebrae of sheep with ceramic prostheses. Yamamuro, T., Shikata, J., Okumura, H., Kitsugi, T., Kakutani, Y., Matsui, T., Kokubo, T. The Journal of bone and joint surgery. British volume. (1990) [Pubmed]
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