- Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. Flagella, M., Clarke, L.L., Miller, M.L., Erway, L.C., Giannella, R.A., Andringa, A., Gawenis, L.R., Kramer, J., Duffy, J.J., Doetschman, T., Lorenz, J.N., Yamoah, E.N., Cardell, E.L., Shull, G.E. J. Biol. Chem. (1999)