- The 16p11 breakpoint in myxoid liposarcomas might affect the expression of the LRP gene on 16p11.2 encoding the multidrug resistance associated major vault protein. Plaat, B.E., Molenaar, W.M., Sagrudny, J., Bohle, R.M., Mastik, M.F., Hoekstra, H.J., Van der Graaf, W.T., Hollema, H., van den Berg, E. Eur. J. Clin. Invest. (2000)