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Gene Review

C19orf48  -  chromosome 19 open reading frame 48

Homo sapiens

Synonyms: MGC13170, Multidrug resistance-related protein, Uncharacterized protein C19orf48
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Disease relevance of C19orf48


High impact information on C19orf48


Chemical compound and disease context of C19orf48


Biological context of C19orf48


Anatomical context of C19orf48


Associations of C19orf48 with chemical compounds


Other interactions of C19orf48


Analytical, diagnostic and therapeutic context of C19orf48


  1. Clinical relevance of immunohistochemical detection of multidrug resistance P-glycoprotein in breast carcinoma. Verrelle, P., Meissonnier, F., Fonck, Y., Feillel, V., Dionet, C., Kwiatkowski, F., Plagne, R., Chassagne, J. J. Natl. Cancer Inst. (1991) [Pubmed]
  2. Therapy of ovarian cancers with targeted cytotoxic analogs of bombesin, somatostatin, and luteinizing hormone-releasing hormone and their combinations. Buchholz, S., Keller, G., Schally, A.V., Halmos, G., Hohla, F., Heinrich, E., Koester, F., Baker, B., Engel, J.B. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection. Chen, G., Jaffrézou, J.P., Fleming, W.H., Durán, G.E., Sikic, B.I. Cancer Res. (1994) [Pubmed]
  4. Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced expression of multidrug resistance-related ABC transporters. Stein, U., Jürchott, K., Walther, W., Bergmann, S., Schlag, P.M., Royer, H.D. J. Biol. Chem. (2001) [Pubmed]
  5. Pleiotropic over-expression of multidrug-resistance-related genes is correlated to MYCN and max mRNA accumulation during tumour progression in the IGR-N-91 human neuroblastoma model. Cappellen, D., Bénard, J. Int. J. Cancer (1997) [Pubmed]
  6. Decreased mutation rate for cellular resistance to doxorubicin and suppression of mdr1 gene activation by the cyclosporin PSC 833. Beketic-Oreskovic, L., Durán, G.E., Chen, G., Dumontet, C., Sikic, B.I. J. Natl. Cancer Inst. (1995) [Pubmed]
  7. Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil. Safa, A.R. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  8. Hepatic canalicular membrane 4: expression of the multidrug resistance genes in the liver. Silverman, J.A., Schrenk, D. FASEB J. (1997) [Pubmed]
  9. Separate roles for the Golgi apparatus and lysosomes in the sequestration of drugs in the multidrug-resistant human leukemic cell line HL-60. Gong, Y., Duvvuri, M., Krise, J.P. J. Biol. Chem. (2003) [Pubmed]
  10. The expression of the multidrug resistance related glycoprotein in adult acute lymphoblastic leukemia. Savignano, C., Geromin, A., Michieli, M., Damiani, D., Michelutti, A., Melli, C., Fanin, R., Baccarani, M. Haematologica (1993) [Pubmed]
  11. Role of glutathione, glutathione S-transferases and multidrug resistance-related proteins in cisplatin sensitivity of head and neck cancer cell lines. Welters, M.J., Fichtinger-Schepman, A.M., Baan, R.A., Flens, M.J., Scheper, R.J., Braakhuis, B.J. Br. J. Cancer (1998) [Pubmed]
  12. Technetium-99m methoxyisobutylisonitrile chest imaging for small-cell lung cancer. Relationship to chemotherapy response (six courses of combination of cisplatin and etoposide) and p-glycoprotein or multidrug resistance related protein expression. Kao, A., Shiun, S.C., Hsu, N.Y., Sun, S.S., Lee, C.C., Lin, C.C. Ann. Oncol. (2001) [Pubmed]
  13. Detecting parathyroid adenoma using technetium-99m tetrofosmin: comparison with P-glycoprotein and multidrug resistance related protein expression--a preliminary report. Shiau, Y.C., Tsai, S.C., Wang, J.J., Ho, S.T., Kao, A. Nucl. Med. Biol. (2002) [Pubmed]
  14. Pgp immunochemistry: use with caution: correspondence re: C-H. Kao et al., P-glycoprotein and multidrug resistance-related protein expressions in relation to technetium-99m methoxyisobutylisonitrile scintimammography findings. Cancer Res., 61: 1412-1414, 2001. Cayre, A., Maublant, J., Penault-Llorca, F. Cancer Res. (2002) [Pubmed]
  15. Characterization of the dexniguldipine binding site in the multidrug resistance-related transport protein P-glycoprotein by photoaffinity labeling and mass spectrometry. Borchers, C., Boer, R., Klemm, K., Figala, V., Denzinger, T., Ulrich, W.R., Haas, S., Ise, W., Gekeler, V., Przybylski, M. Mol. Pharmacol. (2002) [Pubmed]
  16. Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein. Foxwell, B.M., Mackie, A., Ling, V., Ryffel, B. Mol. Pharmacol. (1989) [Pubmed]
  17. Cellular accumulation and activity of quinolones in ciprofloxacin-resistant j774 macrophages. Michot, J.M., Heremans, M.F., Caceres, N.E., Mingeot-Leclercq, M.P., Tulkens, P.M., Van Bambeke, F. Antimicrob. Agents Chemother. (2006) [Pubmed]
  18. Secretion of platelet-activating factor is mediated by MDR1 P-glycoprotein in cultured human mesangial cells. Ernest, S., Bello-Reuss, E. J. Am. Soc. Nephrol. (1999) [Pubmed]
  19. Multidrug resistance-related proteins in primary choroidal melanomas and in vitro cell lines. van der Pol, J.P., Blom, D.J., Flens, M.J., Luyten, G.P., de Waard-Siebinga, I., Koornneef, L., Scheper, R.J., Jager, M.J. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  20. Influence of efflux transporters on the accumulation and efflux of four quinolones (ciprofloxacin, levofloxacin, garenoxacin, and moxifloxacin) in J774 macrophages. Michot, J.M., Seral, C., Van Bambeke, F., Mingeot-Leclercq, M.P., Tulkens, P.M. Antimicrob. Agents Chemother. (2005) [Pubmed]
  21. Multidrug resistance-related transport proteins in isolated human brain microvessels and in cells cultured from these isolates. Seetharaman, S., Barrand, M.A., Maskell, L., Scheper, R.J. J. Neurochem. (1998) [Pubmed]
  22. Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy. Aronica, E., Gorter, J.A., Ramkema, M., Redeker, S., Ozbas-Gerçeker, F., van Vliet, E.A., Scheffer, G.L., Scheper, R.J., van der Valk, P., Baayen, J.C., Troost, D., Ozbas-Gerçerer, F. Epilepsia (2004) [Pubmed]
  23. P-Glycoprotein and multidrug resistance-related protein expressions in relation to technetium-99m methoxyisobutylisonitrile scintimammography findings. Kao, C.H., Tsai, S.C., Liu, T.J., Ho, Y.J., Wang, J.J., Ho, S.T., ChangLai, S.P. Cancer Res. (2001) [Pubmed]
  24. Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance. Imai, Y., Tsukahara, S., Asada, S., Sugimoto, Y. Cancer Res. (2004) [Pubmed]
  25. Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers. Safa, A.R., Glover, C.J., Sewell, J.L., Meyers, M.B., Biedler, J.L., Felsted, R.L. J. Biol. Chem. (1987) [Pubmed]
  26. Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums. Khokhar, N.Z., She, Y., Rusch, V.W., Sirotnak, F.M. Clin. Cancer Res. (2001) [Pubmed]
  27. Binding of sulfonylurea by AtMRP5, an Arabidopsis multidrug resistance-related protein that functions in salt tolerance. Lee, E.K., Kwon, M., Ko, J.H., Yi, H., Hwang, M.G., Chang, S., Cho, M.H. Plant Physiol. (2004) [Pubmed]
  28. Detection of MRP functional activity: calcein AM but not BCECF AM as a Multidrug Resistance-related Protein (MRP1) substrate. Olson, D.P., Taylor, B.J., Ivy, S.P. Cytometry. (2001) [Pubmed]
  29. Expression of lung resistance-related protein, LRP, and multidrug resistance-related protein, MRP1, in normal human lung cells in long-term cultures. Lehmann, T., Torky, A.R., Stehfest, E., Hofmann, S., Foth, H. Arch. Toxicol. (2005) [Pubmed]
  30. In acute myeloid leukemia, coexpression of at least two proteins, including P-glycoprotein, the multidrug resistance-related protein, bcl-2, mutant p53, and heat-shock protein 27, is predictive of the response to induction chemotherapy. Kasimir-Bauer, S., Ottinger, H., Meusers, P., Beelen, D.W., Brittinger, G., Seeber, S., Scheulen, M.E. Exp. Hematol. (1998) [Pubmed]
  31. Clinical characteristics, prognostic factors and multidrug-resistance related protein expression in 36 adult patients with acute promyelocytic leukemia. Candoni, A., Damiani, D., Michelutti, A., Masolini, P., Michieli, M., Michelutti, T., Geromin, A., Fanin, R. Eur. J. Haematol. (2003) [Pubmed]
  32. Antisense inhibition of myeloperoxidase increases the sensitivity of the HL-60 cell line to vincristine. Schlaifer, D., Meyer, K., Muller, C., Attal, M., Smith, M.T., Tamaki, S., Weimels, J., Pris, J., Jaffrézou, J.P., Laurent, G. Leukemia (1994) [Pubmed]
  33. Messenger RNA analysis of the multidrug resistance related protein (MRP1) and the lung resistance protein (LRP) in de novo and relapsed childhood acute lymphoblastic leukemia. Sauerbrey, A., Voigt, A., Wittig, S., Häfer, R., Zintl, F. Leuk. Lymphoma (2002) [Pubmed]
  34. The prognostic significance of P-glycoprotein, multidrug resistance-related protein 1 and lung resistance protein in pediatric acute lymphoblastic leukemia: a retrospective study of 295 newly diagnosed patients by the Children's Oncology Group. Olson, D.P., Taylor, B.J., La, M., Sather, H., Reaman, G.H., Ivy, S.P. Leuk. Lymphoma (2005) [Pubmed]
  35. Venlafaxine induces P-glycoprotein in human Caco-2 cells. Ehret, M.J., Levin, G.M., Narasimhan, M., Rathinavelu, A. Human psychopharmacology (2007) [Pubmed]
  36. Increased expression of lung resistance-related protein in lower grade urothelial carcinoma of the renal pelvis and ureter. Kong, C.Z., Zeng, Y., Wu, X.X., Li, J.Q., Zhu, Y.Y., Chen, Y. International journal of urology : official journal of the Japanese Urological Association. (2004) [Pubmed]
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