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Gene Review

MVP  -  major vault protein

Homo sapiens

Synonyms: LRP, Lung resistance-related protein, Major vault protein, VAULT1
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Disease relevance of MVP


High impact information on MVP


Chemical compound and disease context of MVP


Biological context of MVP

  • Therefore, YB-1 is directly linked to MVP-mediated drug resistance [13].
  • Ectopic upregulation of MVP was seen in hilar neurons in HS, dysplastic neurons in FCD, and lesional neurons in DNT [1].
  • Vaults and MVP have been associated with several cellular processes which are also involved in cancer development like cell motility and differentiation [14].
  • Because cells transfected with the LRP gene did not express the multidrug-resistant phenotype, we investigated whether LRP is involved in multidrug resistance [7].
  • These data indicate that although both the MRP and LRP genes map to the short arm of chromosome 16, they are rarely coamplified and are not normally located within the same amplicon [15].

Anatomical context of MVP


Associations of MVP with chemical compounds

  • 5-FU also induced reporter expressions driven by a panel of newly generated MVP promoter deletion mutants [13].
  • Isolated nuclei from untreated cells or sodium butyrate-treated cells incubated with anti-LRP polyclonal antibodies contained more doxorubicin than the nuclei of sodium butyrate-treated cells alone [7].
  • For lung resistance-related protein, this association was limited to 5-fluorouracil, Adriamycin/epirubicin, and cyclophosphamide [18].
  • The optimal fixation for P-gp (C219, MRK16), MRP (MRPr1) and LRP (LRP56) was a mixture of 2% (v/v) formaldehyde solution and acetone incubated for only 10 s at room temperature (FAc) [2].
  • The results of the present study indicate that resistance in LoVo/C7 cells cannot be attributed to alterations in P-gp, LRP or GSH/GSH-dependent enzyme levels [19].

Physical interactions of MVP


Regulatory relationships of MVP

  • Here, we demonstrate that besides MDR-related cytostatics, also the non-MDR-related drug 5-fluorouracil (5-FU) was able to induce MVP mRNA and protein expression [13].
  • In summary, our data demonstrate a direct involvement of YB-1 in controlling basal and 5-FU-induced MVP promoter activity [13].
  • Mutation of this site distinctly reduced basal as well as IFN-gamma-stimulated MVP transcription [23].
  • Treatment of the tumor cells with EGF or TGFalpha (25 ng/ml) significantly down-regulated total cellular LRP [24].

Other interactions of MVP


Analytical, diagnostic and therapeutic context of MVP


  1. Major vault protein, a marker of drug resistance, is upregulated in refractory epilepsy. Sisodiya, S.M., Martinian, L., Scheffer, G.L., van der Valk, P., Cross, J.H., Scheper, R.J., Harding, B.N., Thom, M. Epilepsia (2003) [Pubmed]
  2. Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia. Den Boer, M.L., Zwaan, C.M., Pieters, R., Kazemier, K.M., Rottier, M.M., Flens, M.J., Scheper, R.J., Veerman, A.J. Leukemia (1997) [Pubmed]
  3. Human T-cell lymphotropic virus type I Tax activates lung resistance-related protein expression in leukemic clones established from an adult T-cell leukemia patient. Sakaki, Y., Terashi, K., Yamaguchi, A., Kawamata, N., Tokito, Y., Mori, H., Umehara, M., Yoshiyama, T., Ohtsubo, H., Arimura, K., Arima, N., Tei, C. Exp. Hematol. (2002) [Pubmed]
  4. Expression of multidrug resistance-associated proteins in rhabdomyosarcomas before and after chemotherapy: the relationship between lung resistance-related protein (LRP) and differentiation. Klunder, J.W., Komdeur, R., Van Der Graaf, W.T., De Bont, E.J., Hoekstra, H.J., Van Den Berg, E., Molenaar, W.M. Hum. Pathol. (2003) [Pubmed]
  5. Coexpression of multidrug resistance involve proteins: a flow cytometric analysis. Boutonnat, J., Bonnefoix, T., Mousseau, M., Seigneurin, D., Ronot, X. Anticancer Res. (1998) [Pubmed]
  6. The drug resistance-related protein LRP is the human major vault protein. Scheffer, G.L., Wijngaard, P.L., Flens, M.J., Izquierdo, M.A., Slovak, M.L., Pinedo, H.M., Meijer, C.J., Clevers, H.C., Scheper, R.J. Nat. Med. (1995) [Pubmed]
  7. Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells. Kitazono, M., Sumizawa, T., Takebayashi, Y., Chen, Z.S., Furukawa, T., Nagayama, S., Tani, A., Takao, S., Aikou, T., Akiyama, S. J. Natl. Cancer Inst. (1999) [Pubmed]
  8. Expression of P-glycoprotein, multidrug resistance-associated protein 1, and lung resistance-related protein in human soft tissue sarcomas before and after hyperthermic isolated limb perfusion with tumor necrosis factor-alpha and melphalan. Komdeur, R., Plaat, B.E., Hoekstra, H.J., Molenaar, W.M., Hollema, H., van den Berg, E., Mastik, M.F., van der Graaf, W.T. Cancer (2001) [Pubmed]
  9. Drug resistance features and S-phase fraction as possible determinants for drug response in a panel of human ovarian cancer xenografts. Kolfschoten, G.M., Hulscher, T.M., Pinedo, H.M., Boven, E. Br. J. Cancer (2000) [Pubmed]
  10. New silicon compounds as resistance modifiers against multidrug-resistant cancer cells. Molnar, J., Mucsi, I., Nacsa, J., Hevér, A., Gyémánt, N., Ugocsai, K., Hegyes, P., Kiessig, S., Gaal, D., Lage, H., Varga, A. Anticancer Res. (2004) [Pubmed]
  11. To predict response chemotherapy using technetium-99m tetrofosmin chest images in patients with untreated small cell lung cancer and compare with p-glycoprotein, multidrug resistance related protein-1, and lung resistance-related protein expression. Kuo, T.H., Liu, F.Y., Chuang, C.Y., Wu, H.S., Wang, J.J., Kao, A. Nucl. Med. Biol. (2003) [Pubmed]
  12. Addition of cyclosporin A to the combination of mitoxantrone and etoposide to overcome resistance to chemotherapy in refractory or relapsing acute myeloid leukaemia:; A randomised phase II trial from HOVON, the Dutch-Belgian Haemato-Oncology Working Group for adults. Daenen, S., Van Der Holt, B., Verhoef, G.E., Löwenberg, B., Wijermans, P.W., Huijgens, P.C., Van Marwijk Kooy, R., Schouten, H.C., Kramer, M.H., Ferrant, A., Van Den Berg, E., Steijaert, M.M., Verdonck, L.F., Sonneveld, P. Leuk. Res. (2004) [Pubmed]
  13. YB-1 facilitates basal and 5-fluorouracil-inducible expression of the human major vault protein (MVP) gene. Stein, U., Bergmann, S., Scheffer, G.L., Scheper, R.J., Royer, H.D., Schlag, P.M., Walther, W. Oncogene (2005) [Pubmed]
  14. Cellular functions of vaults and their involvement in multidrug resistance. Steiner, E., Holzmann, K., Elbling, L., Micksche, M., Berger, W. Current drug targets. (2006) [Pubmed]
  15. The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification. Slovak, M.L., Ho, J.P., Cole, S.P., Deeley, R.G., Greenberger, L., de Vries, E.G., Broxterman, H.J., Scheffer, G.L., Scheper, R.J. Cancer Res. (1995) [Pubmed]
  16. Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours. Zurita, A.J., Diestra, J.E., Condom, E., García Del Muro, X., Scheffer, G.L., Scheper, R.J., Pérez, J., Germà-Lluch, J.R., Izquierdo, M.A. Br. J. Cancer (2003) [Pubmed]
  17. Expression of MDR proteins in breast cancer and its correlation with some clinical and pathological parameters. Rybárová, S., Hodorová, I., Hajduková, M., Schmidtová, K., Mojzis, J., Kajo, K., Kviatkovská, Z., Plank, L., Benický, M., Mirossay, A., Biros, E., Bobrov, N., Wagnerová, M., Berc, A., Mirossay, L. Neoplasma (2006) [Pubmed]
  18. RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response. Burger, H., Foekens, J.A., Look, M.P., Meijer-van Gelder, M.E., Klijn, J.G., Wiemer, E.A., Stoter, G., Nooter, K. Clin. Cancer Res. (2003) [Pubmed]
  19. Characterization of a clonal human colon adenocarcinoma line intrinsically resistant to doxorubicin. Dolfini, E., Dasdia, T., Arancia, G., Molinari, A., Calcabrini, A., Scheper, R.J., Flens, M.J., Gariboldi, M.B., Monti, E. Br. J. Cancer (1997) [Pubmed]
  20. Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein. Minaguchi, T., Waite, K.A., Eng, C. Cancer Res. (2006) [Pubmed]
  21. Structural domains of vault proteins: a role for the coiled coil domain in vault assembly. van Zon, A., Mossink, M.H., Schoester, M., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  22. A novel human zinc finger protein ZNF540 interacts with MVP and inhibits transcriptional activities of the ERK signal pathway. Xiang, Z., Yuan, W., Luo, N., Wang, Y., Tan, K., Deng, Y., Zhou, X., Zhu, C., Li, Y., Liu, M., Wu, X., Li, Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  23. The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals. Steiner, E., Holzmann, K., Pirker, C., Elbling, L., Micksche, M., Sutterlüty, H., Berger, W. J. Cell. Sci. (2006) [Pubmed]
  24. Epidermal growth factor differentially regulates low density lipoprotein receptor-related protein gene expression in neoplastic and fetal human astrocytes. Hussaini, I.M., Brown, M.D., Karns, L.R., Carpenter, J., Redpath, G.T., Gonias, S.L., Vandenberg, S.R. Glia (1999) [Pubmed]
  25. P-glycoprotein, lung resistance-related protein and multidrug resistance-associated protein in de novo adult acute lymphoblastic leukaemia. Damiani, D., Michelutti, A., Michieli, M., Masolini, P., Stocchi, R., Geromin, A., Ermacora, A., Russo, D., Fanin, R., Baccarani, M. Br. J. Haematol. (2002) [Pubmed]
  26. Multidrug resistance: retrospect and prospects in anti-cancer drug treatment. Pérez-Tomás, R. Current medicinal chemistry. (2006) [Pubmed]
  27. Evaluation of MDR1, LRP, MRP, and topoisomerase IIalpha gene mRNA transcripts before and after interferon-alpha, and correlation with the mRNA expression level of the telomerase subunits hTERT and TEP1 in five unselected human melanoma cell lines. Miracco, C., Maellaro, E., Pacenti, L., Del Bello, B., Valentini, M.A., Rubegni, P., Pirtoli, L., Volpi, C., Santopietro, R., Tosi, P. Int. J. Oncol. (2003) [Pubmed]
  28. Increased LRP mRNA expression is associated with the MDR phenotype in intrinsically resistant human cancer cell lines. Laurençot, C.M., Scheffer, G.L., Scheper, R.J., Shoemaker, R.H. Int. J. Cancer (1997) [Pubmed]
  29. P-glycoprotein (PGP), and not lung resistance-related protein (LRP), is a negative prognostic factor in secondary leukemias. Damiani, D., Michieli, M., Ermacora, A., Candoni, A., Raspadori, D., Geromin, A., Stocchi, R., Grimaz, S., Masolini, P., Michelutti, A., Scheper, R.J., Baccarani, M. Haematologica (1998) [Pubmed]
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