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MeSH Review

Liposarcoma, Myxoid

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Disease relevance of Liposarcoma, Myxoid


High impact information on Liposarcoma, Myxoid

  • In human myxoid liposarcoma, a chromosomal rearrangement leads to fusion of the growth-arresting and DNA-damage-inducible transcription factor CHOP (GADD153) to a peptide fragment encoded by the TLS gene [6].
  • The TLS-CHOP oncoprotein, found in the majority of human myxoid liposarcomas, consists of a fusion between the transcription factor CHOP/GADD153 and the N terminus of an RNA-binding protein TLS/FUS [7].
  • However, myxoid liposarcoma DNA samples contained altered restriction fragments detectable with GLI probes that were highly specific and reproducible from case to case [8].
  • Fusion of the EWS and CHOP genes in myxoid liposarcoma [9].
  • Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases [10].

Chemical compound and disease context of Liposarcoma, Myxoid

  • As a tumor progression model, we investigated 26 myxoid liposarcomas (11 pure myxoid grade I, 15 myxoid/round cell grade II/III) for the hTERT expression level and compared the results of the new method with former measurements performed in silver-stained polyacrylamide gels [11].
  • Although a tentative diagnosis of poorly differentiated myxoid liposarcoma was made, ultrastructural examination and Oil Red O fat stain failed to demonstrate the evidence of lipoblastic differentiation, except that occasional cells possessed a small number of fine fat droplets [12].
  • Gadolinium-enhanced imaging is important in differentiating myxoid liposarcoma from benign cystic tumors [13].
  • Myxoid liposarcomas had a high water content and contained considerable amounts of free cholesterol and phospholipids [14].
  • The responsiveness to trabectedin in type II myxoid liposarcoma xenografts was as high as in patients [15].

Biological context of Liposarcoma, Myxoid


Anatomical context of Liposarcoma, Myxoid


Gene context of Liposarcoma, Myxoid


  1. Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21). Panagopoulos, I., Mandahl, N., Mitelman, F., Aman, P. Oncogene (1995) [Pubmed]
  2. The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14. Myklebost, O., Arheden, K., Rogne, S., Geurts van Kessel, A., Mandahl, N., Herz, J., Stanley, K., Heim, S., Mitelman, F. Genomics (1989) [Pubmed]
  3. Parachordoma of the tibia: report of a rare case. Koh, J.S., Chung, J.H., Lee, S.Y., Cho, K.J. Pathol. Res. Pract. (2000) [Pubmed]
  4. Histochemical characterization of mucosubstances in bone and soft tissue-tumors. Kindblom, L.G., Angervall, L. Cancer (1975) [Pubmed]
  5. Decreased expression of CCAAT/enhancer binding protein zeta (C/EBPzeta) in patients with different myeloid diseases. Qian, J., Chen, Z., Lin, J., Wang, W., Cen, J. Leuk. Res. (2005) [Pubmed]
  6. A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP. Zinszner, H., Albalat, R., Ron, D. Genes Dev. (1994) [Pubmed]
  7. Induction of a secreted protein by the myxoid liposarcoma oncogene. Kuroda, M., Wang, X., Sok, J., Yin, Y., Chung, P., Giannotti, J.W., Jacobs, K.A., Fitz, L.J., Murtha-Riel, P., Turner, K.J., Ron, D. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Myxoid liposarcoma with t(12;16) (q13;p11) contains site-specific differences in methylation patterns surrounding a zinc-finger gene mapped to the breakpoint region on chromosome 12. Paulien, S., Turc-Carel, C., Dal Cin, P., Jani-Sait, S., Sreekantaiah, C., Leong, S.P., Vogelstein, B., Kinzler, K.W., Sandberg, A.A., Gemmill, R.M. Cancer Res. (1990) [Pubmed]
  9. Fusion of the EWS and CHOP genes in myxoid liposarcoma. Panagopoulos, I., Höglund, M., Mertens, F., Mandahl, N., Mitelman, F., Aman, P. Oncogene (1996) [Pubmed]
  10. Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases. Antonescu, C.R., Tschernyavsky, S.J., Decuseara, R., Leung, D.H., Woodruff, J.M., Brennan, M.F., Bridge, J.A., Neff, J.R., Goldblum, J.R., Ladanyi, M. Clin. Cancer Res. (2001) [Pubmed]
  11. Analysis of human telomerase reverse transcriptase mRNA (hTERT) expression in myxoid liposarcomas using LightCycler real-time quantitative reverse transcriptase-polymerase chain reaction. Schneider-Stock, R., Emrich, T., Peters, B., Jaeger, V., Roessner, A. Electrophoresis (2001) [Pubmed]
  12. Myxoid liposarcoma with t (12; 16)(q 13; p 11). Possible usefulness of chromosome analysis in a poorly differentiated sarcoma. Ohjimi, Y., Iwasaki, H., Ishiguro, M., Ohgami, A., Yoshitake, K., Fujita, C., Kikuchi, M., Shinohara, N., Kaneko, Y. Pathol. Res. Pract. (1992) [Pubmed]
  13. Myxoid liposarcoma: appearance at MR imaging with histologic correlation. Sung, M.S., Kang, H.S., Suh, J.S., Lee, J.H., Park, J.M., Kim, J.Y., Lee, H.G. Radiographics : a review publication of the Radiological Society of North America, Inc. (2000) [Pubmed]
  14. Composition of fat in different types of liposarcomas in comparison with lipomas. Knipping, G., Popper, H. Cancer Lett. (1989) [Pubmed]
  15. Novel models of myxoid liposarcoma xenografts mimicking the biological and pharmacologic features of human tumors. Frapolli, R., Tamborini, E., Virdis, E., Bello, E., Tarantino, E., Marchini, S., Grosso, F., Sanfilippo, R., Gronchi, A., Tercero, J.C., Peloso, G., Casali, P., Pilotti, S., D'Incalci, M. Clin. Cancer Res. (2010) [Pubmed]
  16. Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator. Uranishi, H., Tetsuka, T., Yamashita, M., Asamitsu, K., Shimizu, M., Itoh, M., Okamoto, T. J. Biol. Chem. (2001) [Pubmed]
  17. Distinct mdm2/p53 expression patterns in liposarcoma subgroups: implications for different pathogenetic mechanisms. Pilotti, S., Della Torre, G., Lavarino, C., Di Palma, S., Sozzi, G., Minoletti, F., Rao, S., Pasquini, G., Azzarelli, A., Rilke, F., Pierotti, M.A. J. Pathol. (1997) [Pubmed]
  18. Myxoid liposarcoma with adipocytic maturation: detection of TLS/CHOP fusion gene transcript. Nakanishi, H., Araki, N., Joyama, S., Higuchi, C., Mano, M., Ishiguro, S., Itoh, K., Ueda, T., Yoshikawa, H. Diagn. Mol. Pathol. (2004) [Pubmed]
  19. RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells. Rapp, T.B., Yang, L., Conrad, E.U., Mandahl, N., Chansky, H.A. J. Orthop. Res. (2002) [Pubmed]
  20. The myxoid liposarcoma specific TLS-CHOP fusion protein localizes to nuclear structures distinct from PML nuclear bodies. Thelin-Järnum, S., Göransson, M., Burguete, A.S., Olofsson, A., Aman, P. Int. J. Cancer (2002) [Pubmed]
  21. High telomerase activity and high HTRT mRNA expression differentiate pure myxoid and myxoid/round-cell liposarcomas. Schneider-Stock, R., Jaeger, V., Rys, J., Epplen, J.T., Roessner, A. Int. J. Cancer (2000) [Pubmed]
  22. Expression of DOL54 is not restricted to myxoid liposarcomas with the FUS-DDIT3 chimera but is found in various sarcomas. Panagopoulos, I., Mertens, F., Isaksson, M., Mandahl, N. Oncol. Rep. (2004) [Pubmed]
  23. The 16p11 breakpoint in myxoid liposarcomas might affect the expression of the LRP gene on 16p11.2 encoding the multidrug resistance associated major vault protein. Plaat, B.E., Molenaar, W.M., Sagrudny, J., Bohle, R.M., Mastik, M.F., Hoekstra, H.J., Van der Graaf, W.T., Hollema, H., van den Berg, E. Eur. J. Clin. Invest. (2000) [Pubmed]
  24. The association between tumour progression and vascularity in myxofibrosarcoma and myxoid/round cell liposarcoma. Mentzel, T., Brown, L.F., Dvorak, H.F., Kuhnen, C., Stiller, K.J., Katenkamp, D., Fletcher, C.D. Virchows Arch. (2001) [Pubmed]
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