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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The cytokinesis gene KEULE encodes a Sec1 protein that binds the syntaxin KNOLLE.

KEULE is required for cytokinesis in Arabidopsis thaliana. We have positionally cloned the KEULE gene and shown that it encodes a Sec1 protein. KEULE is expressed throughout the plant, yet appears enriched in dividing tissues. Cytokinesis-defective mutant sectors were observed in all somatic tissues upon transformation of wild-type plants with a KEULE-green fluorescent protein gene fusion, suggesting that KEULE is required not only during embryogenesis, but at all stages of the plant's life cycle. KEULE is characteristic of a Sec1 protein in that it appears to exist in two forms: soluble or peripherally associated with membranes. More importantly, KEULE binds the cytokinesis-specific syntaxin KNOLLE. Sec1 proteins are key regulators of vesicle trafficking, capable of integrating a large number of intra- and/or intercellular signals. As a cytokinesis-related Sec1 protein, KEULE appears to represent a novel link between cell cycle progression and the membrane fusion apparatus.[1]


  1. The cytokinesis gene KEULE encodes a Sec1 protein that binds the syntaxin KNOLLE. Assaad, F.F., Huet, Y., Mayer, U., Jürgens, G. J. Cell Biol. (2001) [Pubmed]
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