High impact information on KEU

• More importantly, KEULE binds the cytokinesis-specific syntaxin KNOLLE [1].
• KEULE is required for cytokinesis in Arabidopsis thaliana [1].
• As a cytokinesis-related Sec1 protein, KEULE appears to represent a novel link between cell cycle progression and the membrane fusion apparatus [1].
• Cytokinesis-defective mutant sectors were observed in all somatic tissues upon transformation of wild-type plants with a KEULE-green fluorescent protein gene fusion, suggesting that KEULE is required not only during embryogenesis, but at all stages of the plant's life cycle [1].
• KEULE is characteristic of a Sec1 protein in that it appears to exist in two forms: soluble or peripherally associated with membranes [1].

Biological context of KEU

• This complete inhibition of cytokinesis from fertilisation indicates that KN and KEU, have partially redundant functions and interact specifically in vesicle fusion during cytokinesis of somatic cells [2].
• Nonetheless, keule mutants die as seedlings with large polyploid cells [3].

Anatomical context of KEU

• Mutant keule embryos have large multinucleate cells with gapped or incomplete cross walls, as well as cell wall stubs that are very similar to those observed upon caffeine inhibition of cytokinesis in plants [3].

Other interactions of KEU

• Genetic interactions between KN and KEU were analysed in double mutant embryos [2].
• In these and other respects, the new mutants are phenotypically similar to knolle, keule, hinkel, and pleiade mutants [4].

References