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Pfeiffer, N. et al.

Pfeiffer, Grierson, Goldsmith, Hochgesand, Winkgen-Böhres, Appleton,

Histological effects in the iris after 3 months of latanoprost therapy: the Mainz 1 study.

OBJECTIVE: To determine whether 3 months of topical latanoprost treatment caused proliferative or degenerative effects on the peripheral iris of patients with glaucoma. METHODS: Seventeen patients requiring filtering surgery for primary open-angle glaucoma or pseudoexfoliation glaucoma were randomized to receive topical latanoprost for 3 months (n = 8) or alternative medication (n = 9) before surgery. A trabeculectomy and a peripheral iridectomy specimen was obtained from each patient during surgery. The tissue was subjected to histological and immunohistochemical evaluation using 2 cell cycle markers: proliferating cell nuclear antigen and nuclear-associated protein (Ki-67). RESULTS: No degenerative or pathological changes were seen in the latanoprost-treated irides, including the one specimen in this series in which there was an eye color change. Proliferating cell nuclear antigen and nuclear-associated protein markers were negative for changes in all the test specimens. CONCLUSION: Short-term treatment with latanoprost does not produce morphological changes or cellular proliferation changes in the iris.[1]

References

Histological effects in the iris after 3 months of latanoprost therapy: the Mainz 1 study. Pfeiffer, N., Grierson, I., Goldsmith, H., Hochgesand, D., Winkgen-Böhres, A., Appleton, P. Arch. Ophthalmol. (2001) [Pubmed]

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