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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Iridectomy

  • In adults, unilateral sialectomy and iridectomy did not significantly alter ganglion T-OH activity or protein in rats followed up to one month after surgery [1].

High impact information on Iridectomy

  • After unilateral total iridectomy, maximum accommodation inducible by corneal iontophoresis of carbachol in rhesus monkeys was approximately 40% less in the iridectomized than in the contralateral untouched eyes, irrespective of age [2].
  • Total iridectomy in the cynomolgus monkey apparently has little, if any, effect on IOP, outflow facility, or facility response to intravenous pilocarpine, and the iris plays little, if any, role in mediating the facility response to intravenous pilocarpine [3].
  • INTERVENTION: The first patient was treated with a neodymium:YAG laser peripheral iridectomy with hyaloidectomy and with intracameral tissue plasminogen activator [4].
  • A peripheral iridectomy was performed intraoperatively in 14 eyes, whereas 4 additional eyes received a yttrium-aluminum-garnet peripheral iridectomy after surgery [5].
  • Eleven patients (68.7%) required surgical intervention, consisting of laser iridotomy, surgical iridectomy, trabeculectomy with or without 5-fluorouracil, and/or Molteno implantation [6].

Biological context of Iridectomy


Anatomical context of Iridectomy

  • Benzydamine at the concentration of 0.1% reduces inflammatory tissue changes induced by AgNO3 burning of the cornea and inhibits the blood-aqueous barrier breakdown due to peripheral iridectomy or laser irradiation of the iris [8].

Associations of Iridectomy with chemical compounds

  • Histopathology of neodymium: YAG laser iridectomy in humans [9].
  • CONCLUSIONS: The ultrastructure of the iridectomies from the latanoprost-treated eyes and the fellow eyes conformed to published standards for normal iris [10].
  • Total iridectomy does not alter outflow facility responses to cyclic AMP in cynomolgus monkeys [11].
  • Data on intraoperative iris procedures (excess manipulation, pupilloplasty, synechiolysis, peripheral iridectomy) and postoperative topical steroid usage were assessed [12].
  • OBJECTIVES: To examine the histopathologic features of iridectomy specimens from patients undergoing glaucoma surgery and to compare histologic abnormalities in a group of patients with a history of latanoprost therapy with those in a group of patients who had no history of prostaglandin therapy (controls) [13].

Gene context of Iridectomy

  • Tissue plasminogen activator for preserving inferior peripheral iridectomy patency in eyes with silicone oil [14].
  • Five patients had peripheral iridectomy during CLE as the angles were occludable [15].
  • After marked improvement of her condition after administration of activated protein C concentrate, she underwent a left iridectomy and implantation of a Broviak catheter under general anesthesia [16].
  • In the Douible Flap Scheie a conjunctival and scleral flap are made followed by a cornea-scleral cauterization and incision after which a peripheral iridectomy is made [17].

Analytical, diagnostic and therapeutic context of Iridectomy


  1. The effect of taget organ removal on the development of sympathetic neurons. Dibner, M.D., Black, I.B. Brain Res. (1976) [Pubmed]
  2. The role of the iris in accommodation of rhesus monkeys. Crawford, K.S., Kaufman, P.L., Bito, L.Z. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  3. Aqueous humor dynamics following total iridectomy in the cynomolgus monkey. Kaufman, P.L. Invest. Ophthalmol. Vis. Sci. (1979) [Pubmed]
  4. A malignant glaucoma-like syndrome following pars plana vitrectomy. Massicotte, E.C., Schuman, J.S. Ophthalmology (1999) [Pubmed]
  5. High incidence of cataract formation after implantation of a silicone posterior chamber lens in phakic, highly myopic eyes. Brauweiler, P.H., Wehler, T., Busin, M. Ophthalmology (1999) [Pubmed]
  6. Incidence and management of glaucoma in Vogt-Koyanagi-Harada syndrome. Forster, D.J., Rao, N.A., Hill, R.A., Nguyen, Q.H., Baerveldt, G. Ophthalmology (1993) [Pubmed]
  7. Intraocular hemorrhage developing during interferon therapy. Kuga, K., Hasumura, S., Nagamori, S., Toda, G., Kitahara, K. Intern. Med. (1996) [Pubmed]
  8. Effects of benzydamine eye drops on the rabbit's eye reaction to surgical, physical, and chemical stimuli. Tomazzoli, L., Bonora, A., Luparini, M.R., Durando, L., Ciarniello, M.G., Cioli, V., Bonomi, L. Journal of ocular pharmacology. (1989) [Pubmed]
  9. Histopathology of neodymium: YAG laser iridectomy in humans. Rodrigues, M.M., Spaeth, G.L., Moster, M., Thomas, G., Hackett, J. Ophthalmology (1985) [Pubmed]
  10. Fine structural evaluation of the iris after unilateral treatment with latanoprost in patients undergoing bilateral trabeculectomy (the Mainz II study). Pfeiffer, N., Grierson, I., Goldsmith, H., Appleton, P., Hochgesand, D., Winkgen, A. Arch. Ophthalmol. (2003) [Pubmed]
  11. Total iridectomy does not alter outflow facility responses to cyclic AMP in cynomolgus monkeys. Kaufman, P.L. Exp. Eye Res. (1986) [Pubmed]
  12. Cataract formation after penetrating keratoplasty. Rathi, V.M., Krishnamachary, M., Gupta, S. Journal of cataract and refractive surgery. (1997) [Pubmed]
  13. A study of iridectomy histopathologic features of latanoprost- and non-latanoprost-treated patients. Albert, D.M., Gangnon, R.E., Zimbric, M.L., Damico, C.M., Fisher, M.R., Gleiser, J., Grossniklaus, H.E., Green, W.R. Arch. Ophthalmol. (2004) [Pubmed]
  14. Tissue plasminogen activator for preserving inferior peripheral iridectomy patency in eyes with silicone oil. MacCumber, M.W., McCuen, B.W., Toth, C.A., Ferrone, P.J., Jaffe, G.J. Ophthalmology (1996) [Pubmed]
  15. Clear lens extraction with intraocular lens implantation for hyperopia. Preetha, R., Goel, P., Patel, N., Agarwal, S., Agarwal, A., Agarwal, J., Agarwal, T., Agarwal, A. Journal of cataract and refractive surgery. (2003) [Pubmed]
  16. [Perioperative management of a patient with purpura fulminans syndrome due to protein C deficiency]. Kumagai, K., Nishiwaki, K., Sato, K., Kitamura, H., Yano, K., Komatsu, T., Shimada, Y. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2001) [Pubmed]
  17. Four year follow-up of a glaucoma operation. Prospective study of the double flap Scheie. Greve, E.L., Dake, C.L. International ophthalmology. (1979) [Pubmed]
  18. Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures. Chevrier, R.L., Assalian, A., Duperré, J., Lesk, M.R. Ophthalmic surgery and lasers. (1999) [Pubmed]
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