Disease relevance of Trabeculectomy

• This study demonstrates another biologic activity of 5 beta-dihydrocortisol, a metabolite found to accumulate in cells cultured from trabeculectomy specimens from patients with primary open angle glaucoma [1].
• Minoxidil may be a useful drug for the treatment of conditions such as proliferative vitreoretinopathy and bleb scarring after trabeculectomy, disorders with unwanted cell proliferation and collagen production [2].
• Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil [3].
• CONCLUSION: The efficacy of limbal- and fornix-based conjunctival flaps in initial trabeculectomy with postoperative 5-fluorouracil was not significantly different; however, in this study cystic leaking blebs were encountered only in eyes with limbal-based conjunctival flaps [4].
• A comparison of trabeculectomy with topically applied timolol in a rabbit ocular hypertension model [5].

High impact information on Trabeculectomy

• CONCLUSIONS: Laser trabeculoplasty induces the expression and secretion of both IL-1beta and TNFalpha within the first 8 hours after treatment [6].
• METHODS: Argon laser trabeculoplasty, using typical clinical treatment parameters, was applied to anterior segment organ cultures [7].
• Some benefit has also been gained with the use of hyaluronic acid in penetrating keratoplasty, trabeculectomy, retinal reattachment and trauma surgery, although its efficacy in these indications is less well-defined in the published literature [8].
• Postoperative subconjunctival injections of 5-fluorouracil (5-FU) improve the success rate of filtration surgery, but there is still a 20% or greater failure rate at 1 year in pseudophakic and repeat trabeculectomy cases [9].
• Eight keratoplasty and 14 trabeculectomy specimens from Chandler's syndrome, Essential Iris Atrophy, and the Cogan-Reese syndrome were studied by electron microscopic and morphometric methods [10].

Chemical compound and disease context of Trabeculectomy

• CONCLUSION: Argon laser trabeculoplasty is effective in pigmentary glaucoma [11].
• SETTING/PARTICIPANTS: Two hundred fifty-five open-angle glaucoma patients randomized to argon laser trabeculoplasty plus topical betaxolol or no immediate treatment (129 treated; 126 controls) and followed up every 3 months [12].
• Flurbiprofen pretreatment in argon laser trabeculoplasty for primary open-angle glaucoma [13].
• The role of sodium hyaluronate (Healonid) in trabeculectomy to prevent a shallow or flat anterior chamber and hypotonia in the immediate postoperative period is reported [14].
• RESULTS: Intensive steroid treatment resulted in steroid-induced glaucoma, which required bilateral trabeculectomies, but the uveitis became inactive [15].

Biological context of Trabeculectomy

• The efficacy of brimonidine in decreasing elevations in intraocular pressure after laser trabeculoplasty [16].
• Trabeculectomy following MMP-3 transfection caused significantly longer survival of filtering bleb and decreased levels of IOP in comparison with controls (trabeculectomy alone or trabeculectomy following vector transfection), and these levels were almost identical to those of trabeculectomy with MMC [17].
• PURPOSE: To investigate and compare the effects of suramin and mitomycin C on conjunctival wound healing after trabeculectomy in a rabbit model [18].
• 15 eyes with glaucomatous visual field defects were followed with computerized perimetry before and nearly one year after Argon Laser Trabeculoplasty [19].

Anatomical context of Trabeculectomy

• Aqueous humor uric acid and ascorbic acid concentrations and outcome of trabeculectomy [20].
• PURPOSE: To control intraocular pressure in patients treated by trabeculectomy, progressive inflammation, fibroblast proliferation, and the enhanced expression of extracellular matrix (ECM), causes of scar formation at the bleb, must be prevented [21].
• CONCLUSION: Fluorouracil- and mitomycin C-supplemented trabeculectomies cause similar changes in the lens and corneal endothelium [22].
• Combined perfluoropropane gas and viscoelastic material injection for anterior chamber reformation following trabeculectomy [23].
• Suramin modulates wound healing of rabbit conjunctiva after trabeculectomy: comparison with mitomycin C [18].

Associations of Trabeculectomy with chemical compounds

• This was achieved within 6 months by means of fistulizing surgery or with pilocarpine and/or laser trabeculoplasty [24].
• PhEA 34c, a 1.9% solution of sodium hyaluronate (Healon = 1.0%) was injected intracamerally and between the scleral and conjunctival flaps after trabeculectomy in 15 eyes, while randomized controls received balanced salt solution (BSS) [25].
• CONCLUSION: Apraclonidine effectively decreased large IOP elevations in glaucomatous eyes undergoing trabeculectomy combined with extracapsular cataract surgery [26].
• Nonsteroidal anti-inflammatory agents after argon laser trabeculoplasty. A trial with flurbiprofen and indomethacin [27].
• Treated patients had laser trabeculoplasty and started receiving topical betaxolol twice daily in eligible eyes [28].

Gene context of Trabeculectomy

• The increases in trabecular stromelysin and gelatinase B in response to laser trabeculoplasty may have important implications for the mechanism of action of this treatment for open-angle glaucoma [29].
• We used tissue plasminogen activator (tPA) subconjunctivally in an attempt to release a trabeculectomy flap that appeared to be adherent to its scleral bed [30].
• The use of subconjunctivally administered tissue plasminogen activator after trabeculectomy [30].
• To investigate this possibility, 20 trabeculectomy specimens obtained from patients with primary open-angle glaucoma (POAG) were examined immunohistochemically for HLA-DR, leucocyte common antigen (LCA; CD45) and a macrophage marker (CD68) [31].
• Nine of 14 eyes that had been treated with carbonic anhydrase inhibitors were controlled without these drugs after trabeculoplasty [32].

Analytical, diagnostic and therapeutic context of Trabeculectomy

• CONCLUSION: Postoperative 5-FU may improve the 1-year success rate of trabeculectomy combined with clear-cornea phacoemulsification [33].
• Effect of topical apraclonidine on the frequency of intraocular pressure elevations after combined extracapsular cataract extraction and trabeculectomy [26].
• CONCLUSIONS: 5-Fluorouracil and MMC were found to be equally safe and effective adjuncts to primary trabeculectomy in the short- and medium-term postoperative periods [34].
• 5-Fluorouracil in initial trabeculectomy. A prospective, randomized, multicenter study [35].
• Ultrasound biomicroscopy of two eyes showed a shallow supraciliary fluid level, anterior rotation of ciliary processes, and obstruction of the trabeculectomy osteum [36].

References