Disease relevance of Filtering Surgery

• CONCLUSION: There is a high risk of long-term failure of filtering surgery with 5-FU in neovascular glaucoma [1].
• The use of 5-fluorouracil, which is an antimetabolite with considerable corneal epithelial toxicity, after glaucoma filtering surgery frequently causes corneal epithelial defects that may lead to secondary complications [2].
• Bleb-associated endophthalmitis occurred in 2 eyes following filtering surgery with no antifibrotic agent, in 6 eyes following trabeculectomy with 5-FU, and in 7 eyes that underwent trabeculectomy with intraoperative MMC [3].
• In a prospective randomized study, we compare the results at 20 months of 5 Fluoro-Uracil and Daunorubicin filtering surgery in two groups of 25 patients with primary open-angle glaucoma [4].
• Use of 5-FU as an adjuvant to filtering surgery in various complicated glaucomas improves the long-term results [5].

High impact information on Filtering Surgery

• CONCLUSIONS: The combined treatment with EP and bleomycin was found to decrease IOP more prominently than EP or bleomycin treatment alone in filtering surgery [6].
• 5-fluorouracil and steroids have been used to suppress excessive scar formation after glaucoma filtering surgery (GFS) [7].
• These results suggest that IFN-gamma may be a useful agent for modifying the wound healing response, particularly after glaucoma filtering surgery [8].
• We studied the effect of two compounds, beta-aminopropionitrile (BAPN) and D-penicillamine on the success of experimental glaucoma filtering surgery in cynomolgus monkeys [9].
• D-penicillamine and beta-aminopropionitrile effects on experimental filtering surgery [9].

Biological context of Filtering Surgery

• PURPOSE: To investigate the effects of topical instillation of 0.5% tranilast eye drops on intraocular pressure (IOP) and bleb formation after glaucoma filtering surgery [10].
• Several earlier studies have shown improvement of glaucomatous visual fields after pressure reduction achieved by acetazolamide or filtering surgery, while other studies have given conflicting results [11].

Anatomical context of Filtering Surgery

• 5-Fluorouracil (5-FU) has effectively inhibited fibroblast proliferation to prevent scar formation and bleb failure after glaucoma filtering surgery [12].
• As filtering surgery with 5-fluorouracil is more effective and simple to perform, we conclude that the anterior chamber tube shunt to an encircling band procedure should be reserved for those with refractory glaucoma who have had multiple surgical interventions [13].

Associations of Filtering Surgery with chemical compounds

• A study was made in rabbits of the effect of topical dexamethasone ointment, .05%, and either subconjunctival or intraperitoneal D-penicillamine on the duration of function of glaucoma filtering surgery [14].
• CONCLUSION: Daunorubicin in a bioerodible delivery system may potentially be a useful adjunct to glaucoma filtering surgery and requires further evaluation [15].
• METHODS: Small (1-cc) specimens of Tenon capsule were removed at the time of filtering surgery from 15 glaucoma patients under long-term preoperative topical therapy, nine of whom had been treated with timolol and six of whom had been receiving betaxolol [16].
• Use of trypan blue to confirm the patency of filtering surgery [17].
• Pupil dilatation with intracameral 1% lidocaine during glaucoma filtering surgery [18].

Gene context of Filtering Surgery

• Effect of human RAD50 gene therapy on glaucoma filtering surgery in rabbit eye [19].
• PURPOSE: Transforming growth factor-beta1 (TGF-beta1) is thought to play a pivotal role in the regulation of the wound healing process after glaucoma filtering surgery [20].
• Chymase and angiotensin converting enzyme activities in a hamster model of glaucoma filtering surgery [21].
• To evaluate the potential of interferon-alpha 2b (IFN-alpha) as an antifibrotic treatment after glaucoma filtering surgery, we studied its ability to inhibit mitogen-induced proliferation of human Tenon's capsule fibroblasts in vitro, as shown by [3H]-thymidine incorporation [22].
• After glaucoma filtering surgery subconjunctival injection of human recombinant tissue plasminogen activator may promote the function of glaucoma filter bleb and increase outflow facility [23].

Analytical, diagnostic and therapeutic context of Filtering Surgery

• It is the authors' impression that postoperative subconjunctival 5-FU increases the likelihood of achieving IOP control after filtering surgery in eyes with poor surgical prognoses; however, a randomized clinical trial is necessary to confirm this impression [24].
• Each rabbit underwent trabeculectomy on both eyes, then one of the 5-FU and/or MMC preparations was placed at the site of the filtering surgery intraoperatively in the right eye, while the left eye was used as a control [25].
• In this preliminary retrospective study, results of combined extracapsular cataract extraction, intraocular lens implantation, and filtering surgery with subconjunctival 5-fluorouracil (5-FU) injections in 22 eyes were compared with those obtained in a similar group without 5-FU injections [26].

References