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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Xu, H.X. et al.

Activity of plant flavonoids against antibiotic-resistant bacteria.

Thirty eight plant-derived flavonoids representing seven different structural groups were tested for activities against antibiotic-resistant bacteria using the disc-diffusion assay and broth dilution assay. Among the flavonoids examined, four flavonols (myricetin, datiscetin, kaempferol and quercetin) and two -flavones (flavone and luteolin) exhibited inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA). Myricetin was also found to inhibit the growth of multidrug-resistant Burkholderia -cepacia, vancomycin-resistant enterococci (VRE) and other medically important organisms such as -Klebsiella pneumoniae and Staphylococcus epidermidis. Myricetin was bactericidal to B. cepacia. The results of the radiolabel incorporation assay showed that myricetin inhibited protein synthesis by -B. cepacia. The structure-activity relationship of these flavonoids is discussed.[1]

References

Activity of plant flavonoids against antibiotic-resistant bacteria. Xu, H.X., Lee, S.F. Phytotherapy research : PTR. (2001) [Pubmed]

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