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Chemical Compound Review

luteolin     2-(3,4-dihydroxyphenyl)-5,7- dihydroxy...

Synonyms: Luteolol, Flacitran, Luteoline, Salifazide, Digitoflavone, ...
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Disease relevance of Luteoline


High impact information on Luteoline

  • Through a random genetic search to find loci that are required for expression of the Rhizobium meliloti nod (nodulation) genes, we isolated a mutant (B4) defective in luteolin-dependent activation of nod gene expression, and found it carries a Tn5 insertion within a chromosomal groEL gene (groELc) located just downstream of a groESc gene [6].
  • Luteolin influenced migration by modulating the activity of Rho GTPases, signal transducers involved in transendothelial migration [7].
  • Luteolin treatment resulted in reduced inflammation and axonal damage in the CNS by preventing monocyte migration across the brain endothelium [7].
  • Nodule initiation signals were not involved, since LMW succinoglycan from R. meliloti nodD1D2D3 and nodA mutants and from luteolin-induced wild-type cultures elicited effects similar to LMW succinoglycan from the uninduced wild-type strain [8].
  • An overexpression in STAT3 led to resistance to luteolin, suggesting that STAT3 was a critical target of luteolin [2].

Chemical compound and disease context of Luteoline


Biological context of Luteoline

  • Here we found that pretreatment with a noncytotoxic concentration of luteolin significantly sensitized TRAIL-induced apoptosis in both TRAIL-sensitive (HeLa) and TRAIL-resistant cancer cells (CNE1, HT29, and HepG2) [14].
  • Surprisingly, luteolin did not affect VEGF-induced phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases, a pathway that is considered important for the mitotic effects of VEGF [15].
  • In contrast, other flavonoids such as flavone, luteolin, and the structurally similar daidzein arrested the cell cycle at G1 [16].
  • Next, we showed that protein kinase C (PKC) activation prevented cell death induced by luteolin and TRAIL via suppression of XIAP down-regulation [14].
  • In search of the molecular mechanism responsible for XIAP down-regulation, we found that luteolin and TRAIL promoted XIAP ubiquitination and proteasomal degradation [14].

Anatomical context of Luteoline


Associations of Luteoline with other chemical compounds


Gene context of Luteoline


Analytical, diagnostic and therapeutic context of Luteoline


  1. A plant flavone, luteolin, induces expression of Rhizobium meliloti nodulation genes. Peters, N.K., Frost, J.W., Long, S.R. Science (1986) [Pubmed]
  2. Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids. Selvendiran, K., Koga, H., Ueno, T., Yoshida, T., Maeyama, M., Torimura, T., Yano, H., Kojiro, M., Sata, M. Cancer Res. (2006) [Pubmed]
  3. Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. Shi, R.X., Ong, C.N., Shen, H.M. Oncogene (2004) [Pubmed]
  4. Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice. Kotanidou, A., Xagorari, A., Bagli, E., Kitsanta, P., Fotsis, T., Papapetropoulos, A., Roussos, C. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  5. Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. Yi, L., Li, Z., Yuan, K., Qu, X., Chen, J., Wang, G., Zhang, H., Luo, H., Zhu, L., Jiang, P., Chen, L., Shen, Y., Luo, M., Zuo, G., Hu, J., Duan, D., Nie, Y., Shi, X., Wang, W., Han, Y., Li, T., Liu, Y., Ding, M., Deng, H., Xu, X. J. Virol. (2004) [Pubmed]
  6. The Rhizobium meliloti groELc locus is required for regulation of early nod genes by the transcription activator NodD. Ogawa, J., Long, S.R. Genes Dev. (1995) [Pubmed]
  7. Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis. Hendriks, J.J., Alblas, J., van der Pol, S.M., van Tol, E.A., Dijkstra, C.D., de Vries, H.E. J. Exp. Med. (2004) [Pubmed]
  8. Specific oligosaccharide form of the Rhizobium meliloti exopolysaccharide promotes nodule invasion in alfalfa. Battisti, L., Lara, J.C., Leigh, J.A. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Specific binding of proteins from Rhizobium meliloti cell-free extracts containing NodD to DNA sequences upstream of inducible nodulation genes. Fisher, R.F., Egelhoff, T.T., Mulligan, J.T., Long, S.R. Genes Dev. (1988) [Pubmed]
  10. Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis. Mittra, B., Saha, A., Chowdhury, A.R., Pal, C., Mandal, S., Mukhopadhyay, S., Bandyopadhyay, S., Majumder, H.K. Mol. Med. (2000) [Pubmed]
  11. Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in Escherichia coli. Leonard, E., Chemler, J., Lim, K.H., Koffas, M.A. Appl. Microbiol. Biotechnol. (2006) [Pubmed]
  12. Polyphenols from plants used in traditional Indonesian medicine (Jamu): uptake and antioxidative effects in rat H4IIE hepatoma cells. Steffan, B., Wätjen, W., Michels, G., Niering, P., Wray, V., Ebel, R., Edrada, R., Kahl, R., Proksch, P. J. Pharm. Pharmacol. (2005) [Pubmed]
  13. Chemopreventive potential of luteolin during colon carcinogenesis induced by 1,2-dimethylhydrazine. Manju, V., Nalini, N. Ital. J. Biochem. (2005) [Pubmed]
  14. Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells. Shi, R.X., Ong, C.N., Shen, H.M. Cancer Res. (2005) [Pubmed]
  15. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity. Bagli, E., Stefaniotou, M., Morbidelli, L., Ziche, M., Psillas, K., Murphy, C., Fotsis, T. Cancer Res. (2004) [Pubmed]
  16. Genistein arrests cell cycle progression at G2-M. Matsukawa, Y., Marui, N., Sakai, T., Satomi, Y., Yoshida, M., Matsumoto, K., Nishino, H., Aoike, A. Cancer Res. (1993) [Pubmed]
  17. Directly energized uptake of beta-estradiol 17-(beta-D-glucuronide) in plant vacuoles is strongly stimulated by glutathione conjugates. Klein, M., Martinoia, E., Weissenböck, G. J. Biol. Chem. (1998) [Pubmed]
  18. Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin. Xagorari, A., Roussos, C., Papapetropoulos, A. Br. J. Pharmacol. (2002) [Pubmed]
  19. Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. Chen, C.C., Chow, M.P., Huang, W.C., Lin, Y.C., Chang, Y.J. Mol. Pharmacol. (2004) [Pubmed]
  20. Bioflavonoids attenuate renal proximal tubular cell injury during cold preservation in Euro-Collins and University of Wisconsin solutions. Ahlenstiel, T., Burkhardt, G., Köhler, H., Kuhlmann, M.K. Kidney Int. (2003) [Pubmed]
  21. Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells. Fang, J., Zhou, Q., Shi, X.L., Jiang, B.H. Carcinogenesis (2007) [Pubmed]
  22. Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Chowdhury, A.R., Sharma, S., Mandal, S., Goswami, A., Mukhopadhyay, S., Majumder, H.K. Biochem. J. (2002) [Pubmed]
  23. Identification of nolR-regulated proteins in Sinorhizobium meliloti using proteome analysis. Chen, H., Higgins, J., Kondorosi, E., Kondorosi, A., Djordjevic, M.A., Weinman, J.J., Rolfe, B.G. Electrophoresis (2000) [Pubmed]
  24. Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. Shimoi, K., Okada, H., Furugori, M., Goda, T., Takase, S., Suzuki, M., Hara, Y., Yamamoto, H., Kinae, N. FEBS Lett. (1998) [Pubmed]
  25. Luteolin prevents PDGF-BB-induced proliferation of vascular smooth muscle cells by inhibition of PDGF beta-receptor phosphorylation. Kim, J.H., Jin, Y.R., Park, B.S., Kim, T.J., Kim, S.Y., Lim, Y., Hong, J.T., Yoo, H.S., Yun, Y.P. Biochem. Pharmacol. (2005) [Pubmed]
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