Chemical Compound Review:
luteolin 2-(3,4-dihydroxyphenyl)-5,7- dihydroxy...
Synonyms:
Luteolol, Flacitran, Luteoline, Salifazide, Digitoflavone, ...
- A plant flavone, luteolin, induces expression of Rhizobium meliloti nodulation genes. Peters, N.K., Frost, J.W., Long, S.R. Science (1986)
- Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids. Selvendiran, K., Koga, H., Ueno, T., Yoshida, T., Maeyama, M., Torimura, T., Yano, H., Kojiro, M., Sata, M. Cancer Res. (2006)
- Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. Shi, R.X., Ong, C.N., Shen, H.M. Oncogene (2004)
- Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice. Kotanidou, A., Xagorari, A., Bagli, E., Kitsanta, P., Fotsis, T., Papapetropoulos, A., Roussos, C. Am. J. Respir. Crit. Care Med. (2002)
- Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. Yi, L., Li, Z., Yuan, K., Qu, X., Chen, J., Wang, G., Zhang, H., Luo, H., Zhu, L., Jiang, P., Chen, L., Shen, Y., Luo, M., Zuo, G., Hu, J., Duan, D., Nie, Y., Shi, X., Wang, W., Han, Y., Li, T., Liu, Y., Ding, M., Deng, H., Xu, X. J. Virol. (2004)
- The Rhizobium meliloti groELc locus is required for regulation of early nod genes by the transcription activator NodD. Ogawa, J., Long, S.R. Genes Dev. (1995)
- Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis. Hendriks, J.J., Alblas, J., van der Pol, S.M., van Tol, E.A., Dijkstra, C.D., de Vries, H.E. J. Exp. Med. (2004)
- Specific oligosaccharide form of the Rhizobium meliloti exopolysaccharide promotes nodule invasion in alfalfa. Battisti, L., Lara, J.C., Leigh, J.A. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Specific binding of proteins from Rhizobium meliloti cell-free extracts containing NodD to DNA sequences upstream of inducible nodulation genes. Fisher, R.F., Egelhoff, T.T., Mulligan, J.T., Long, S.R. Genes Dev. (1988)
- Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis. Mittra, B., Saha, A., Chowdhury, A.R., Pal, C., Mandal, S., Mukhopadhyay, S., Bandyopadhyay, S., Majumder, H.K. Mol. Med. (2000)
- Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in Escherichia coli. Leonard, E., Chemler, J., Lim, K.H., Koffas, M.A. Appl. Microbiol. Biotechnol. (2006)
- Polyphenols from plants used in traditional Indonesian medicine (Jamu): uptake and antioxidative effects in rat H4IIE hepatoma cells. Steffan, B., Wätjen, W., Michels, G., Niering, P., Wray, V., Ebel, R., Edrada, R., Kahl, R., Proksch, P. J. Pharm. Pharmacol. (2005)
- Chemopreventive potential of luteolin during colon carcinogenesis induced by 1,2-dimethylhydrazine. Manju, V., Nalini, N. Ital. J. Biochem. (2005)
- Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells. Shi, R.X., Ong, C.N., Shen, H.M. Cancer Res. (2005)
- Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity. Bagli, E., Stefaniotou, M., Morbidelli, L., Ziche, M., Psillas, K., Murphy, C., Fotsis, T. Cancer Res. (2004)
- Genistein arrests cell cycle progression at G2-M. Matsukawa, Y., Marui, N., Sakai, T., Satomi, Y., Yoshida, M., Matsumoto, K., Nishino, H., Aoike, A. Cancer Res. (1993)
- Directly energized uptake of beta-estradiol 17-(beta-D-glucuronide) in plant vacuoles is strongly stimulated by glutathione conjugates. Klein, M., Martinoia, E., Weissenböck, G. J. Biol. Chem. (1998)
- Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin. Xagorari, A., Roussos, C., Papapetropoulos, A. Br. J. Pharmacol. (2002)
- Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. Chen, C.C., Chow, M.P., Huang, W.C., Lin, Y.C., Chang, Y.J. Mol. Pharmacol. (2004)
- Bioflavonoids attenuate renal proximal tubular cell injury during cold preservation in Euro-Collins and University of Wisconsin solutions. Ahlenstiel, T., Burkhardt, G., Köhler, H., Kuhlmann, M.K. Kidney Int. (2003)
- Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells. Fang, J., Zhou, Q., Shi, X.L., Jiang, B.H. Carcinogenesis (2007)
- Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Chowdhury, A.R., Sharma, S., Mandal, S., Goswami, A., Mukhopadhyay, S., Majumder, H.K. Biochem. J. (2002)
- Identification of nolR-regulated proteins in Sinorhizobium meliloti using proteome analysis. Chen, H., Higgins, J., Kondorosi, E., Kondorosi, A., Djordjevic, M.A., Weinman, J.J., Rolfe, B.G. Electrophoresis (2000)
- Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. Shimoi, K., Okada, H., Furugori, M., Goda, T., Takase, S., Suzuki, M., Hara, Y., Yamamoto, H., Kinae, N. FEBS Lett. (1998)
- Luteolin prevents PDGF-BB-induced proliferation of vascular smooth muscle cells by inhibition of PDGF beta-receptor phosphorylation. Kim, J.H., Jin, Y.R., Park, B.S., Kim, T.J., Kim, S.Y., Lim, Y., Hong, J.T., Yoo, H.S., Yun, Y.P. Biochem. Pharmacol. (2005)