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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2.

Glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) are coencoded within a single mammalian proglucagon precursor, and are liberated in the intestine and brain. GLP-1 exerts well known actions on islet hormone secretion, gastric emptying, and food intake. Recent studies suggest GLP-1 plays a central role in the development and organization of islet cells. GLP-1 receptor signaling appears essential for beta cell signal transduction as exemplified by studies of GLP-1R-/- mice. GLP-2 promotes energy assimilation via trophic effects on the intestinal mucosa of the small and large bowel epithelium via a recently cloned GLP-2 receptor. The actions of GLP-2 are preserved in the setting of small and large bowel injury and inflammation. The biological actions of the glucagon-like peptides suggest they may have therapeutic efficacy in diabetes (GLP-1) or intestinal disorders (GLP-2).[1]


  1. New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2. Drucker, D.J., Lovshin, J., Baggio, L., Nian, M., Adatia, F., Boushey, R.P., Liu, Y., Saleh, J., Yusta, B., Scrocchi, L. Ann. N. Y. Acad. Sci. (2000) [Pubmed]
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