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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Depressed cell-mediated immunity in megaloblastic anemia due to folic acid deficiency.

Cell-mediated immunity has been studied in patients with 1) megaloblastic anemia of folic acid deficiency, 2)megaloblastic anemia of pregnancy, or 3) iron-deficiency anemia. Using dinitrochlorobenzene skin tests, phytohemagglutinin-stimulated lymphocyte transformation, and rosette inhibition by antilymphocyte globulin, we have shown that cell-mediated immunity is depressed in megaloblastic anemia due to folate deficiency; this depression was reversed by folate treatment. Cell-mediated immunity was not impaired by iron-deficiency anemia. Suggested interactions between iron deficiency and folate metabolism were not clarified by these studies.[1]


  1. Depressed cell-mediated immunity in megaloblastic anemia due to folic acid deficiency. Gross, R.L., Reid, J.V., Newberne, P.M., Burgess, B., Marston, R., Hift, W. Am. J. Clin. Nutr. (1975) [Pubmed]
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