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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effects of conductive hearing loss on gerbil central auditory system activity in silence.

Animal models of conductive hearing loss (CHL) show altered structure and function in the central auditory system ( CAS), particularly following unilateral deprivation. Assessment of neuronal activity as measured by 2-deoxyglucose (2-DG) uptake following CHL has been reported by two groups of investigators, with different findings. Woolf and colleagues [Brain Res. 274 (1983) 119] found that 2-DG uptake increased in the cochlear nucleus ipsilateral to the CHL, while Tucci et al. [Laryngoscope 109 (1999) 1359] found a decrease in 2-DG uptake in the ipsilateral cochlear nucleus. One significant difference between the protocols in the two studies was that, in the first study, animals were maintained in silence following 2-DG injection, whereas in the Tucci et al. study, animals were exposed to sound. The current study was designed to replicate the protocol used by Woolf et al. Young adult gerbils underwent unilateral malleus removal with bilateral canal ligation (n=6) or a sham procedure (n=7) 48 h prior to 2-DG administration and sacrifice. Optical density measurements were made from CAS nuclei. 2-DG uptake decreased in the ipsilateral cochlear nucleus and contralateral inferior colliculus, and in nuclei of the superior olivary complex bilaterally, supporting the finding that CHL is associated with a decrease in CAS neuronal activity.[1]


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